DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and GHR1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001320016.1	Gene:	GHR1 / 827842	AraportID:	AT4G20940	Length:	1037	Species:	Arabidopsis thaliana

Alignment Length:	603	Identity:	166/603 - (27%)
Similarity:	252/603 - (41%)	Gaps:	134/603 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 LERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDV--NELGFRDRSKEPTNGSTESTSTTES 264
            |:.|.|:::..:||    |..|::|..|:||.|.|..|  |:||                    |
plant    60 LDNLGLTADADFSL----FSNLTKLVKLSMSNNSLSGVLPNDLG--------------------S 100

  Fly   265 AKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQI 329
            .|           .|::||:|.|.|........|....||.||::.|..|....:::.||.:||.
plant   101 FK-----------SLQFLDLSDNLFSSSLPKEIGRSVSLRNLSLSGNNFSGEIPESMGGLISLQS 154

  Fly   330 LNLSSNKIVA-LPTELFAEQAKIIQEVY--LQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWI 391
            |::|||.:.. ||..|    .::...:|  |.:|..:...|:.|..:..|:.|||..|.|... :
plant   155 LDMSSNSLSGPLPKSL----TRLNDLLYLNLSSNGFTGKMPRGFELISSLEVLDLHGNSIDGN-L 214

  Fly   392 DKNTFVGLIRLVLLNLSHNKLT----KLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHT 452
            |...|: |.....:::|.|:|.    ||.|.:..   :::.|||.|||||......|....||..
plant   215 DGEFFL-LTNASYVDISGNRLVTTSGKLLPGVSE---SIKHLNLSHNQLEGSLTSGFQLFQNLKV 275

  Fly   453 LLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSA--LQDLNLNGNQLKTVPLAL 515
            |.||:|.|.. :....|.:|.|.:|.|.||...|..|:......:  |..|:|:||.| :.|::.
plant   276 LDLSYNMLSG-ELPGFNYVYDLEVLKLSNNRFSGSLPNNLLKGDSLLLTTLDLSGNNL-SGPVSS 338

  Fly   516 RNMRHLRTVDLGENMITVMEDSAFKG-----LGNLYGLRLIGNYLE-NITMHTFRDLPNLQILNL 574
            .....|.|:||..|.:|        |     .|....|.|..|..| |:|  .:....|::.|:|
plant   339 IMSTTLHTLDLSSNSLT--------GELPLLTGGCVLLDLSNNQFEGNLT--RWSKWENIEYLDL 393

  Fly   575 ARNRIAVVEPGAF-EMTSSIQAVRLDGNELN-DINGLFSNM--------PSLLWLNISDNRLESF 629
            ::|...    |:| :.|..:    |..|.|| ..|.|..::        |.|..|:||.|.||
plant   394 SQNHFT----GSFPDATPQL----LRANHLNLSYNKLTGSLPERIPTHYPKLRVLDISSNSLE-- 448

  Fly   630 DYGHVPS------TLQWLDLHKN----------------RLSSLS-NRFGLD------SELKLQT 665
              |.:|.      ||:.:.|..|                ||..|| |||..|      |...||.
plant   449 --GPIPGALLSMPTLEEIHLQNNGMTGNIGPLPSSGSRIRLLDLSHNRFDGDLPGVFGSLTNLQV 511

  Fly   666 LDVSFNQLQRIGPSSIPNSIEL--LFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLR 728
            |:::.|.|....|||:.:.:.|  |.::.|..|...|...  .:|:...::..|.::....::|:
plant   512 LNLAANNLSGSLPSSMNDIVSLSSLDVSQNHFTGPLPSNL--SSNIMAFNVSYNDLSGTVPENLK 574

  Fly   729 ILPVWEHRALPEFYIGGN 746
            ..|.      |.||.|.:
plant   575 NFPP------PSFYPGNS 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	12/33 (36%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	19/77 (25%)
		leucine-rich repeat	229..249	CDD:275380	9/21 (43%)
		LRR_RI	278..468	CDD:238064	60/196 (31%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	301..386	CDD:290566	27/87 (31%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	9/23 (39%)
		LRR	350..729	CDD:227223	118/433 (27%)
		leucine-rich repeat	352..375	CDD:275380	5/24 (21%)
		leucine-rich repeat	376..401	CDD:275380	9/24 (38%)
		LRR_RI	<401..626	CDD:238064	71/246 (29%)
		leucine-rich repeat	402..425	CDD:275380	6/26 (23%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..473	CDD:275380	7/22 (32%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	7/19 (37%)
		leucine-rich repeat	521..544	CDD:275380	7/27 (26%)
		leucine-rich repeat	545..566	CDD:275380	6/21 (29%)
		leucine-rich repeat	569..592	CDD:275380	6/23 (26%)
		leucine-rich repeat	593..615	CDD:275380	6/30 (20%)
		leucine-rich repeat	616..637	CDD:275380	9/26 (35%)
		leucine-rich repeat	638..662	CDD:275380	12/46 (26%)
		leucine-rich repeat	663..684	CDD:275380	8/20 (40%)
		leucine-rich repeat	685..708	CDD:275380	5/24 (21%)
		leucine-rich repeat	709..728	CDD:275380	1/18 (6%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
GHR1	NP_001320016.1	PLN00113	2..1036	CDD:215061	166/603 (28%)
		leucine-rich repeat	80..103	CDD:275380	12/53 (23%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	9/26 (35%)
		leucine-rich repeat	176..199	CDD:275380	5/22 (23%)
		leucine-rich repeat	200..223	CDD:275380	9/24 (38%)
		leucine-rich repeat	224..248	CDD:275380	6/26 (23%)
		leucine-rich repeat	249..272	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..314	CDD:275380	7/17 (41%)
		leucine-rich repeat	344..387	CDD:275380	14/52 (27%)
		leucine-rich repeat	388..412	CDD:275380	7/31 (23%)
		leucine-rich repeat	413..436	CDD:275380	5/22 (23%)
		leucine-rich repeat	437..460	CDD:275380	9/26 (35%)
		leucine-rich repeat	461..484	CDD:275380	3/22 (14%)
		leucine-rich repeat	485..508	CDD:275380	9/22 (41%)
		leucine-rich repeat	509..532	CDD:275380	8/22 (36%)
		leucine-rich repeat	533..553	CDD:275380	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000