DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Tlr9

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_112455.2 Gene:Tlr9 / 81897 MGIID:1932389 Length:1032 Species:Mus musculus


Alignment Length:1329 Identity:286/1329 - (21%)
Similarity:442/1329 - (33%) Gaps:456/1329 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 RTLRPL-----------TAGAGGDPSLYDA---PD---DCHFMPAAGLDQPEIALTCNLRTVNSE 106
            |||.||           |...|..|:....   |.   ||:::....:.:...|.:|:       
Mouse     6 RTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAASCS------- 63

  Fly   107 FDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQY-CKLGRLGRQVLDGLE 170
             :.|..|:|    :..:|.|.|.:           |.||..|:||:::: |.        ..||.
Mouse    64 -NITRLSLI----SNRIHHLHNSD-----------FVHLSNLRQLNLKWNCP--------PTGLS 104

  Fly   171 QLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENR 235
            .|..           :.:..||...|...|.||.|:||.|.|.::|                  |
Mouse   105 PLHF-----------SCHMTIEPRTFLAMRTLEELNLSYNGITTVP------------------R 140

  Fly   236 LQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTL 300
            |              |::                         |..|.:||.:.:||.||....|
Mouse   141 L--------------PSS-------------------------LVNLSLSHTNILVLDANSLAGL 166

  Fly   301 RRLRVLSVNNN--------GISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYL 357
            ..||||.::.|        |...:...||.||.||..|:|..|.:..:|.:|    ...::.:.:
Mouse   167 YSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQL----PPSLEYLLV 227

  Fly   358 QNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSH---------NKLT 413
            ..|.|..|.|:..:||..|:.||:..|                   .....|         .|..
Mouse   228 SYNLIVKLGPEDLANLTSLRVLDVGGN-------------------CRRCDHAPNPCIECGQKSL 273

  Fly   414 KLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLS 478
            .|.||                        ||..:::|..|:|..:.|..|::....||..||:|.
Mouse   274 HLHPE------------------------TFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLSVLD 314

  Fly   479 LDNNALIG--VHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKG 541
            |..|.|..  .|.:||:|.:.|:.|||:.|..|.|..|   ..||.              |:||.
Mouse   315 LSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFA---RLHLA--------------SSFKN 362

  Fly   542 LGNLYGLRLIGNYLENITMHTFR---DLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNEL 603
            |.:|..|.:.|.:...:..:|.|   |||.|..|:|                           ::
Mouse   363 LVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHL---------------------------QM 400

  Fly   604 NDIN----GLFSNMPSLLWLNISDNRLESFDYGHVPSTLQ----------------WLDLHKNRL 648
            |.||    .:|....:|.::::||||:..      ||||.                ..|.|...|
Mouse   401 NFINQAQLSIFGTFRALRFVDLSDNRISG------PSTLSEATPEEADDAEQEELLSADPHPAPL 459

  Fly   649 SSLSNRFGLD--SELKLQTLDVSFNQLQRIGPSSIPN--SIELLFLNDNLIT-TVDPDTFMHKTN 708
            |:.:::..:|  ...|. |:|:|.|.|..|.|....|  .::.|.|:.|.|. .|:...|:..||
Mouse   460 STPASKNFMDRCKNFKF-TMDLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTN 523

  Fly   709 LTRVDLYANQITTLDIKSLRILPVWEHRALPEFY---------IGGNPFTCDCNIDWLQKINHIT 764
            |..:||..|::.....||...||  :.:||...|         ||.| |:...::..||.::...
Mouse   524 LQVLDLSHNKLDLYHWKSFSELP--QLQALDLSYNSQPFSMKGIGHN-FSFVTHLSMLQSLSLAH 585

  Fly   765 SRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTN 829
            :       |:.|.....||:.                                            
Mouse   586 N-------DIHTRVSSHLNSN-------------------------------------------- 599

  Fly   830 CTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSN 894
                     |...::.||.....|     .|...||:          |.|.|...|..|..:.:|
Mouse   600 ---------SVRFLDFSGNGMGRM-----WDEGGLYL----------HFFQGLSGLLKLDLSQNN 640

  Fly   895 VAHIYNTTFSGL-KRLLILHLEDNH----------------IISLEGNEFHNLEN--------LR 934
            :..:.......| |.|.:|.|.||:                ::.|.||:...|.|        |:
Mouse   641 LHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQ 705

  Fly   935 ELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFE-VWQLSANPYLVEISLAD---NQWSCEC 995
            :|.:.||.|.|:....|.:..:|:.:.|..|.|...: .|   ..|.::.:::.|   |...|.|
Mouse   706 KLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSW---FGPIVMNLTVLDVRSNPLHCAC 767

  Fly   996 GYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGL----- 1055
            |                  |:.|..:....|.|....||.||.         ...:::|.     
Mouse   768 G------------------AAFVDLLLEVQTKVPGLANGVKCG---------SPGQLQGRSIFAQ 805

  Fly  1056 ----------------LPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCL--MNFCYKSPR 1102
                            |.||.||.       |::..:..:.....:|.....||  :....:|.|
Mouse   806 DLRLCLDEVLSWDCFGLSLLAVAV-------GMVVPILHHLCGWDVWYCFHLCLAWLPLLARSRR 863

  Fly  1103 FVDQLDKERPNDAYFAYSLQDE---HFVNQILAQTLENDIG---YRLCLHYRDVNINAYITDALI 1161
            ....|    |.||:..:.....   .:|...|...||...|   .||||..||......:.:.|.
Mouse   864 SAQTL----PYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLW 924

  Fly  1162 EAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVV--FILYGDLPQRDIDMDMRHYLR 1224
            .:...:::.:.||:.....:...|..:..|...|::.||.||  .||..| ..|...:.:|..|.
Mouse   925 ASIYGSRKTLFVLAHTDRVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPD-AHRSRYVRLRQRLC 988

  Fly  1225 TSTCIEWDDKK-----FWQKLRLALPLPN 1248
            ..:.:.|..:.     ||.:|..||...|
Mouse   989 RQSVLFWPQQPNGQGGFWAQLSTALTRDN 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 6/23 (26%)
LRR_8 171..236 CDD:290566 13/64 (20%)
leucine-rich repeat 172..201 CDD:275380 4/28 (14%)
leucine-rich repeat 202..278 CDD:275380 11/75 (15%)
leucine-rich repeat 229..249 CDD:275380 2/19 (11%)
LRR_RI 278..468 CDD:238064 48/206 (23%)
leucine-rich repeat 279..302 CDD:275380 9/22 (41%)
LRR_8 301..386 CDD:290566 27/92 (29%)
leucine-rich repeat 303..326 CDD:275380 10/30 (33%)
leucine-rich repeat 327..350 CDD:275380 6/22 (27%)
LRR 350..729 CDD:227223 100/417 (24%)
leucine-rich repeat 352..375 CDD:275380 6/22 (27%)
leucine-rich repeat 376..401 CDD:275380 4/24 (17%)
LRR_RI <401..626 CDD:238064 57/242 (24%)
leucine-rich repeat 402..425 CDD:275380 5/31 (16%)
leucine-rich repeat 426..449 CDD:275380 2/22 (9%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 10/24 (42%)
leucine-rich repeat 498..518 CDD:275380 8/19 (42%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 5/23 (22%)
leucine-rich repeat 569..592 CDD:275380 3/22 (14%)
leucine-rich repeat 593..615 CDD:275380 4/25 (16%)
leucine-rich repeat 616..637 CDD:275380 6/20 (30%)
leucine-rich repeat 638..662 CDD:275380 6/41 (15%)
leucine-rich repeat 663..684 CDD:275380 8/22 (36%)
leucine-rich repeat 685..708 CDD:275380 6/23 (26%)
leucine-rich repeat 709..728 CDD:275380 6/18 (33%)
LRR_8 883..943 CDD:290566 19/84 (23%)
leucine-rich repeat 885..908 CDD:275380 4/23 (17%)
leucine-rich repeat 909..932 CDD:275380 9/38 (24%)
LRR_8 932..990 CDD:290566 15/69 (22%)
leucine-rich repeat 933..956 CDD:275380 7/22 (32%)
TIR 1114..1247 CDD:214587 35/145 (24%)
Tlr9NP_112455.2 leucine-rich repeat 43..64 CDD:275380 4/28 (14%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 47..51 0/3 (0%)
LRR 1 62..85 8/45 (18%)
LRR_8 63..135 CDD:290566 26/113 (23%)
leucine-rich repeat 65..88 CDD:275380 9/37 (24%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 72..77 0/4 (0%)
LRR 2 87..110 7/41 (17%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 95..109 4/32 (13%)
LRR 3 122..147 13/81 (16%)
leucine-rich repeat 125..168 CDD:275380 20/99 (20%)
LRR_8 143..211 CDD:290566 24/92 (26%)
LRR 4 150..166 6/15 (40%)
LRR 5 167..190 6/22 (27%)
leucine-rich repeat 169..200 CDD:275380 10/30 (33%)
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 179..181 0/1 (0%)
LRR_RI <194..373 CDD:238064 61/242 (25%)
LRR 6 198..221 8/26 (31%)
LRR_8 199..254 CDD:290566 16/58 (28%)
leucine-rich repeat 201..221 CDD:275380 6/23 (26%)
leucine-rich repeat 222..245 CDD:275380 6/22 (27%)
LRR 7 223..242 4/18 (22%)
LRR 8 243..268 6/43 (14%)
leucine-rich repeat 246..285 CDD:275380 11/81 (14%)
LRR 9 283..306 5/22 (23%)
LRR_8 284..344 CDD:290566 21/59 (36%)
leucine-rich repeat 286..309 CDD:275380 7/22 (32%)
LRR 10 308..332 9/23 (39%)
leucine-rich repeat 310..335 CDD:275380 10/24 (42%)
LRR 11 333..356 8/25 (32%)
leucine-rich repeat 336..365 CDD:275380 14/45 (31%)
LRR 12 363..386 5/22 (23%)
LRR 13 390..413 9/49 (18%)
leucine-rich repeat 393..411 CDD:275380 6/44 (14%)
LRR 14 415..440 9/30 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 430..462 8/31 (26%)
LRR 15 471..495 8/24 (33%)
leucine-rich repeat 477..498 CDD:275380 8/20 (40%)
LRR_RI <490..>641 CDD:238064 43/228 (19%)
LRR_8 497..556 CDD:290566 18/60 (30%)
LRR 16 497..520 6/22 (27%)
leucine-rich repeat 499..523 CDD:275380 6/23 (26%)
LRR 17 521..544 8/22 (36%)
leucine-rich repeat 524..547 CDD:275380 8/24 (33%)
LRR 18 546..573 8/29 (28%)
leucine-rich repeat 548..577 CDD:275380 7/29 (24%)
LRR 19 575..599 6/30 (20%)
leucine-rich repeat 578..600 CDD:275380 6/81 (7%)
leucine-rich repeat 601..630 CDD:275380 9/43 (21%)
LRR 20 601..623 6/36 (17%)
LRR_8 <623..690 CDD:290566 16/66 (24%)
LRR 21 628..651 3/22 (14%)
leucine-rich repeat 631..679 CDD:275380 10/47 (21%)
LRR 22 653..676 6/22 (27%)
LRR 23 677..700 5/22 (23%)
leucine-rich repeat 680..703 CDD:275380 5/22 (23%)
LRR 24 702..724 7/21 (33%)
leucine-rich repeat 704..752 CDD:275380 13/50 (26%)
LRR 25 725..748 5/25 (20%)
LRR 26 750..773 6/40 (15%)
leucine-rich repeat 753..774 CDD:275380 7/38 (18%)
TIR_2 870..>974 CDD:304906 25/103 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.780

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