DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and TLR10

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_112218.2 Gene:TLR10 / 81793 HGNCID:15634 Length:811 Species:Homo sapiens


Alignment Length:948 Identity:190/948 - (20%)
Similarity:341/948 - (35%) Gaps:286/948 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   405 LNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALN 469
            |:||:|.|.:|:...|..:..|::|.|.||:::.:...||.....|..|.||:|:||.:..|.|.
Human    53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLA 117

  Fly   470 GLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLA--LRNMRHLRTVDLGENMIT 532
            |                           |:.|:|:.|...|:|:.  ..||.||..:.|....| 
Human   118 G---------------------------LRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKI- 154

  Fly   533 VMEDSAFKGLGNLY------GLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTS 591
              :.|.|:.:.:|:      |.|.:.:|.|.          :|.|||  ..::.:|.|       
Human   155 --QKSDFQKIAHLHLNTVFLGFRTLPHYEEG----------SLPILN--TTKLHIVLP------- 198

  Fly   592 SIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFG 656
                  :|.|               .|:.:.|.                  :..:::..::|   
Human   199 ------MDTN---------------FWVLLRDG------------------IKTSKILEMTN--- 221

  Fly   657 LDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITT 721
            :|.:.:.    ||:...:.:...:...|:.||                :|.:|...||:      
Human   222 IDGKSQF----VSYEMQRNLSLENAKTSVLLL----------------NKVDLLWDDLF------ 260

  Fly   722 LDIKSLRILPVWEHRALPEFYI-----GGNPFTCDCNIDWLQ------KINHITSRQYPRIMDLE 775
                 |.:..|| |.::..|.|     ||..:....:.|:..      |:.|:..|.:  .:..:
Human   261 -----LILQFVW-HTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVF--YIQQD 317

  Fly   776 TIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWST 840
            .||. ||...:...:.:..|:..|                        |..|...|.|....::.
Human   318 KIYL-LLTKMDIENLTISNAQMPH------------------------MLFPNYPTKFQYLNFAN 357

  Fly   841 NIVECSGAAYSEMPRR---VPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHI---- 898
            ||:.      .|:.:|   :| ....|.::||....|         :|...:|||:.:.|:    
Human   358 NILT------DELFKRTIQLP-HLKTLILNGNKLETL---------SLVSCFANNTPLEHLDLSQ 406

  Fly   899 -------------------YNTTFSGL---------KRLLILHLEDNHIISLEGNEFHNLENLRE 935
                               .|.:::.|         |.:.||.|.:|.|.::.....| |..|||
Human   407 NLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIH-LMALRE 470

  Fly   936 LYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLAR 1000
            |.:..|.:..:...|.  ..:|.||.::.|.::...:..:.:...:..::...|.:.|.|    .
Human   471 LNIAFNFLTDLPGCSH--FSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTC----E 529

  Fly  1001 FRNY--LGQSSEKIID--ASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLV 1061
            .:|:  |...||.::.  :...:|.|.      ....||:  |:|     :|.:|:.....||:|
Human   530 LKNFIQLETYSEVMMVGWSDSYTCEYP------LNLRGTR--LKD-----VHLHELSCNTALLIV 581

  Fly  1062 ATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFV-----DQLDKERPNDAYFAYSL 1121
            .....:...||.....|...:|..:..    ::..|.::...|     :||.:.....|:.:||.
Human   582 TIVVIMLVLGLAVAFCCLHFDLPWYLR----MLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSE 642

  Fly  1122 QDEHFVNQILAQTLENDIG-YRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSR 1185
            .|..:|...|...||.:.| ..:||:....:....|::.::...|.:.:.:.|||.||:.|||..
Human   643 HDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCH 707

  Fly  1186 FEYKSALHELV-KRRKRVVFILYGDLPQRDIDM---DMRHYLRTSTCIEW--DDKK---FWQKLR 1241
            :|:..|.|.|. :....::.||...:|...|..   .::..|.....:||  |.:|   ||..||
Human   708 YEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLR 772

  Fly  1242 LALPLPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQ 1279
            .|:                       :||:.||...|:
Human   773 AAI-----------------------NVNVLATREMYE 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380
LRR 299..654 CDD:443914 53/256 (21%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
leucine-rich repeat 402..425 CDD:275380 7/19 (37%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 10/22 (45%)
leucine-rich repeat 474..497 CDD:275380 0/22 (0%)
leucine-rich repeat 498..518 CDD:275380 6/21 (29%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 5/26 (19%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 2/21 (10%)
leucine-rich repeat 616..637 CDD:275380 2/20 (10%)
leucine-rich repeat 638..662 CDD:275380 2/23 (9%)
LRR_8 662..719 CDD:404697 9/56 (16%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 3/22 (14%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR <863..>990 CDD:443914 29/158 (18%)
leucine-rich repeat 885..908 CDD:275380 7/54 (13%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 39/142 (27%)
TLR10NP_112218.2 LRR 1 24..46
LRR <33..267 CDD:443914 65/335 (19%)
LRR 2 49..70 7/16 (44%)
leucine-rich repeat 50..73 CDD:275378 7/19 (37%)
LRR_8 72..129 CDD:404697 21/83 (25%)
LRR 3 73..94 7/20 (35%)
leucine-rich repeat 74..97 CDD:275378 7/22 (32%)
LRR 4 97..118 9/20 (45%)
leucine-rich repeat 98..112 CDD:275378 7/13 (54%)
leucine-rich repeat 119..143 CDD:275378 8/23 (35%)
LRR 5 119..139 6/19 (32%)
LRR 6 143..166 6/25 (24%)
leucine-rich repeat 144..155 CDD:275378 3/13 (23%)
LRR 7 296..321 4/26 (15%)
LRR 8 325..348 4/46 (9%)
LRR <348..>524 CDD:443914 37/194 (19%)
LRR 9 349..368 4/24 (17%)
LRR 10 373..394 5/29 (17%)
leucine-rich repeat 374..398 CDD:275378 8/32 (25%)
LRR 11 398..419 1/20 (5%)
leucine-rich repeat 399..444 CDD:275378 3/44 (7%)
LRR 12 422..442 2/19 (11%)
LRR 13 444..465 6/21 (29%)
leucine-rich repeat 445..467 CDD:275378 7/22 (32%)
LRR 14 467..488 6/22 (27%)
leucine-rich repeat 468..481 CDD:275378 5/12 (42%)
LRR 15 489..509 4/19 (21%)
leucine-rich repeat 491..513 CDD:275380 3/21 (14%)
LRRCT 522..574 CDD:214507 15/68 (22%)
TIR 633..775 CDD:214587 38/141 (27%)
Blue background indicates that the domain is not in the aligned region.

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