DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and TLR10

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001017388.1	Gene:	TLR10 / 81793	HGNCID:	15634	Length:	811	Species:	Homo sapiens

Alignment Length:	948	Identity:	190/948 - (20%)
Similarity:	341/948 - (35%)	Gaps:	286/948 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 LNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALN 469
            |:||:|.|.:|:...|..:..|::|.|.||:::.:...||.....|..|.||:|:||.:..|.|.
Human    53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLA 117

  Fly   470 GLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLA--LRNMRHLRTVDLGENMIT 532
            |                           |:.|:|:.|...|:|:.  ..||.||..:.|....|
Human   118 G---------------------------LRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKI- 154

  Fly   533 VMEDSAFKGLGNLY------GLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTS 591
              :.|.|:.:.:|:      |.|.:.:|.|.          :|.|||  ..::.:|.|
Human   155 --QKSDFQKIAHLHLNTVFLGFRTLPHYEEG----------SLPILN--TTKLHIVLP------- 198

  Fly   592 SIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFG 656
                  :|.|               .|:.:.|.                  :..:::..::|
Human   199 ------MDTN---------------FWVLLRDG------------------IKTSKILEMTN--- 221

  Fly   657 LDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITT 721
            :|.:.:.    ||:...:.:...:...|:.||                :|.:|...||:
Human   222 IDGKSQF----VSYEMQRNLSLENAKTSVLLL----------------NKVDLLWDDLF------ 260

  Fly   722 LDIKSLRILPVWEHRALPEFYI-----GGNPFTCDCNIDWLQ------KINHITSRQYPRIMDLE 775
                 |.:..|| |.::..|.|     ||..:....:.|:..      |:.|:..|.:  .:..:
Human   261 -----LILQFVW-HTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVF--YIQQD 317

  Fly   776 TIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWST 840
            .||. ||...:...:.:..|:..|                        |..|...|.|....::.
Human   318 KIYL-LLTKMDIENLTISNAQMPH------------------------MLFPNYPTKFQYLNFAN 357

  Fly   841 NIVECSGAAYSEMPRR---VPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHI---- 898
            ||:.      .|:.:|   :| ....|.::||....|         :|...:|||:.:.|:
Human   358 NILT------DELFKRTIQLP-HLKTLILNGNKLETL---------SLVSCFANNTPLEHLDLSQ 406

  Fly   899 -------------------YNTTFSGL---------KRLLILHLEDNHIISLEGNEFHNLENLRE 935
                               .|.:::.|         |.:.||.|.:|.|.::.....| |..|||
Human   407 NLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIH-LMALRE 470

  Fly   936 LYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLAR 1000
            |.:..|.:..:...|.  ..:|.||.::.|.::...:..:.:...:..::...|.:.|.|    .
Human   471 LNIAFNFLTDLPGCSH--FSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTC----E 529

  Fly  1001 FRNY--LGQSSEKIID--ASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLV 1061
            .:|:  |...||.::.  :...:|.|.      ....||:  |:|     :|.:|:.....||:|
Human   530 LKNFIQLETYSEVMMVGWSDSYTCEYP------LNLRGTR--LKD-----VHLHELSCNTALLIV 581

  Fly  1062 ATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFV-----DQLDKERPNDAYFAYSL 1121
            .....:...||.....|...:|..:..    ::..|.::...|     :||.:.....|:.:||.
Human   582 TIVVIMLVLGLAVAFCCLHFDLPWYLR----MLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSE 642

  Fly  1122 QDEHFVNQILAQTLENDIG-YRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSR 1185
            .|..:|...|...||.:.| ..:||:....:....|::.::...|.:.:.:.|||.||:.|||..
Human   643 HDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCH 707

  Fly  1186 FEYKSALHELV-KRRKRVVFILYGDLPQRDIDM---DMRHYLRTSTCIEW--DDKK---FWQKLR 1241
            :|:..|.|.|. :....::.||...:|...|..   .::..|.....:||  |.:|   ||..||
Human   708 YEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLR 772

  Fly  1242 LALPLPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQ 1279
            .|:                       :||:.||...|:
Human   773 AAI-----------------------NVNVLATREMYE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	22/62 (35%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223	65/331 (20%)
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064	53/228 (23%)
		leucine-rich repeat	402..425	CDD:275380	7/19 (37%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	10/22 (45%)
		leucine-rich repeat	474..497	CDD:275380	0/22 (0%)
		leucine-rich repeat	498..518	CDD:275380	6/21 (29%)
		leucine-rich repeat	521..544	CDD:275380	5/22 (23%)
		leucine-rich repeat	545..566	CDD:275380	5/26 (19%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	2/21 (10%)
		leucine-rich repeat	616..637	CDD:275380	2/20 (10%)
		leucine-rich repeat	638..662	CDD:275380	2/23 (9%)
		leucine-rich repeat	663..684	CDD:275380	2/20 (10%)
		leucine-rich repeat	685..708	CDD:275380	3/22 (14%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566	20/91 (22%)
		leucine-rich repeat	885..908	CDD:275380	7/54 (13%)
		leucine-rich repeat	909..932	CDD:275380	7/22 (32%)
		LRR_8	932..990	CDD:290566	10/57 (18%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	39/142 (27%)
TLR10	NP_001017388.1	LRR 1	24..46
		LRR 2	49..70		7/16 (44%)
		leucine-rich repeat	50..73	CDD:275378	7/19 (37%)
		LRR_8	72..129	CDD:316378	21/83 (25%)
		LRR 3	73..94		7/20 (35%)
		leucine-rich repeat	74..97	CDD:275378	7/22 (32%)
		LRR 4	97..118		9/20 (45%)
		leucine-rich repeat	98..112	CDD:275378	7/13 (54%)
		leucine-rich repeat	119..143	CDD:275378	8/23 (35%)
		LRR 5	119..139		6/19 (32%)
		LRR 6	143..166		6/25 (24%)
		leucine-rich repeat	144..155	CDD:275378	3/13 (23%)
		LRR	289..>522	CDD:227223	48/278 (17%)
		LRR 7	296..321		4/26 (15%)
		LRR 8	325..348		4/46 (9%)
		LRR 9	349..368		4/24 (17%)
		leucine-rich repeat	350..373	CDD:275380	6/29 (21%)
		LRR 10	373..394		5/29 (17%)
		leucine-rich repeat	374..398	CDD:275380	8/32 (25%)
		LRR 11	398..419		1/20 (5%)
		leucine-rich repeat	399..422	CDD:275380	1/22 (5%)
		LRR 12	422..442		2/19 (11%)
		leucine-rich repeat	423..444	CDD:275380	2/20 (10%)
		LRR 13	444..465		6/21 (29%)
		leucine-rich repeat	445..467	CDD:275380	7/22 (32%)
		LRR 14	467..488		6/22 (27%)
		leucine-rich repeat	468..490	CDD:275380	6/23 (26%)
		LRR 15	489..509		4/19 (21%)
		leucine-rich repeat	491..513	CDD:275380	3/21 (14%)
		LRRCT	522..574	CDD:214507	15/68 (22%)
		TIR	633..775	CDD:214587	38/141 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820