DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and PSKR1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_178330.1	Gene:	PSKR1 / 814753	AraportID:	AT2G02220	Length:	1008	Species:	Arabidopsis thaliana

Alignment Length:	1125	Identity:	244/1125 - (21%)
Similarity:	383/1125 - (34%)	Gaps:	344/1125 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 SSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNL 332
            :|||||.|.           ::..:..|...|.|.:| |.:.|..:|....::|..|..:::|||
plant    55 NSSSSTDCC-----------NWTGITCNSNNTGRVIR-LELGNKKLSGKLSESLGKLDEIRVLNL 107

  Fly   333 SSNKIV-ALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMN------------ 384
            |.|.|. ::|..:|  ..|.:|.:.|.:|.:|...|... ||..||:.|||.|
plant   108 SRNFIKDSIPLSIF--NLKNLQTLDLSSNDLSGGIPTSI-NLPALQSFDLSSNKFNGSLPSHICH 169

  Fly   385 ---QITSTWIDKNTFVGLI-----RLVLLN---LSHNKLTKLEPEIFSDLYTLQILNLRHNQLEN 438
               ||....:..|.|.|..     :.|||.   |..|.||...||....|..|.:|.::.|:|..
plant   170 NSTQIRVVKLAVNYFAGNFTSGFGKCVLLEHLCLGMNDLTGNIPEDLFHLKRLNLLGIQENRLSG 234

  Fly   439 IAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNL 503
            ..:.....:::|..|.:|.|..........:.|..|.......|..||..|.:..|..:|..|||
plant   235 SLSREIRNLSSLVRLDVSWNLFSGEIPDVFDELPQLKFFLGQTNGFIGGIPKSLANSPSLNLLNL 299

  Fly   504 NGNQLK-TVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLP 567
            ..|.|. .:.|....|..|.::|||.|                   |..|...||:.     |..
plant   300 RNNSLSGRLMLNCTAMIALNSLDLGTN-------------------RFNGRLPENLP-----DCK 340

  Fly   568 NLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDIN---GLFSNMPSL----LWLNISDNR 625
            .|:.:|||||......|.:|:...|:....|..:.|.:|:   |:..:..:|    |.||.....
plant   341 RLKNVNLARNTFHGQVPESFKNFESLSYFSLSNSSLANISSALGILQHCKNLTTLVLTLNFHGEA 405

  Fly   626 LESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLF- 689
            |......|. ..|:.|.:...||:....|: |.|..:||.||:|:|:|....||.|.:...|.:
plant   406 LPDDSSLHF-EKLKVLVVANCRLTGSMPRW-LSSSNELQLLDLSWNRLTGAIPSWIGDFKALFYL 468

  Fly   690 -LNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCN 753
             |::|..|...|.:.....:||..::..|:.:                  |:|     ||
plant   469 DLSNNSFTGEIPKSLTKLESLTSRNISVNEPS------------------PDF-----PF----- 505

  Fly   754 IDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIE------AEP--KHFLCTYKTHCFA 810
              ::::.....:.||.:|.               .:.|.||      :.|  :.|....|.|.|
plant   506 --FMKRNESARALQYNQIF---------------GFPPTIELGHNNLSGPIWEEFGNLKKLHVF- 552

  Fly   811 VCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSG---AAYSEMPRRVPMDTSELYIDGNNFV 872
                                    |..|:.    .||   ::.|.|.....:|.|...:.|:..|
plant   553 ------------------------DLKWNA----LSGSIPSSLSGMTSLEALDLSNNRLSGSIPV 589

  Fly   873 ELAGHSFLGRKNLAVLYANNSNV-------AHIYNTTFSGLKRLLILHLEDNHIIS------LEG 924
            .|...|||.:  .:|.|.|.|.|       ....|::|           |.||:..      .||
plant   590 SLQQLSFLSK--FSVAYNNLSGVIPSGGQFQTFPNSSF-----------ESNHLCGEHRFPCSEG 641

  Fly   925 NEFHNLENLRELYLQSNKIA---SIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISL 986
            .|...::..|.  .:...|.   .||.||..:|..|.::.|...|...      ..:|   ||..
plant   642 TESALIKRSRR--SRGGDIGMAIGIAFGSVFLLTLLSLIVLRARRRSG------EVDP---EIEE 695

  Fly   987 ADNQWSCECGYLARFRNYLGQSSEK------IID-------ASRVSC-----IYNNATSVLREKN 1033
            :::....|.|.:......|.||::|      ::|       |:.:.|     :|
plant   696 SESMNRKELGEIGSKLVVLFQSNDKELSYDDLLDSTNSFDQANIIGCGGFGMVY----------- 749

  Fly  1034 GTKCTLRDG-------------------------VAHYMHTNEIEGLLPLLLVATCAFVAFFGLI 1073
              |.||.||                         ::...|.|       |:|:....|.....|:
plant   750 --KATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPN-------LVLLRGFCFYKNDRLL 805

  Fly  1074 FGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLEND 1138
            ...:.....|..|.|..|       ..|..:....:.|                   :||.....
plant   806 IYSYMENGSLDYWLHERN-------DGPALLKWKTRLR-------------------IAQGAAKG 844

  Fly  1139 IGYRLCLH--------YRDV---------NINAYITD----ALIEAAESAKQFVLVLSKNFL--- 1179
            :.|   ||        :||:         |.|:::.|    .|:...|:.....||.:..::
plant   845 LLY---LHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPYETHVSTDLVGTLGYIPPE 906

  Fly  1180 YNEWSRFEYKSALHELVKRRKRVVFI-LYGDLPQRDIDM--------------DMRHYLRTSTCI 1229
            |.:.|...||..::..     .||.: |..|  :|.:||              .|:|..|.|...
plant   907 YGQASVATYKGDVYSF-----GVVLLELLTD--KRPVDMCKPKGCRDLISWVVKMKHESRASEVF 964

  Fly  1230 E------WDDKKFWQKLRLA 1243
            :      .:||:.::.|.:|
plant   965 DPLIYSKENDKEMFRVLEIA 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	6/9 (67%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	54/213 (25%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		LRR_8	301..386	CDD:290566	29/100 (29%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	8/23 (35%)
		LRR	350..729	CDD:227223	106/411 (26%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..401	CDD:275380	11/44 (25%)
		LRR_RI	<401..626	CDD:238064	60/235 (26%)
		leucine-rich repeat	402..425	CDD:275380	10/25 (40%)
		leucine-rich repeat	426..449	CDD:275380	4/22 (18%)
		leucine-rich repeat	450..473	CDD:275380	5/22 (23%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	5/22 (23%)
		leucine-rich repeat	545..566	CDD:275380	4/20 (20%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	4/24 (17%)
		leucine-rich repeat	616..637	CDD:275380	6/24 (25%)
		leucine-rich repeat	638..662	CDD:275380	7/23 (30%)
		leucine-rich repeat	663..684	CDD:275380	10/20 (50%)
		leucine-rich repeat	685..708	CDD:275380	5/24 (21%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566	14/72 (19%)
		leucine-rich repeat	885..908	CDD:275380	7/29 (24%)
		leucine-rich repeat	909..932	CDD:275380	6/28 (21%)
		LRR_8	932..990	CDD:290566	13/60 (22%)
		leucine-rich repeat	933..956	CDD:275380	7/25 (28%)
		TIR	1114..1247	CDD:214587	33/175 (19%)
PSKR1	NP_178330.1	PLN00113	11..1008	CDD:215061	244/1125 (22%)
		leucine-rich repeat	80..101	CDD:275380	6/21 (29%)
		leucine-rich repeat	102..125	CDD:275380	8/24 (33%)
		leucine-rich repeat	126..148	CDD:275380	7/22 (32%)
		leucine-rich repeat	149..173	CDD:275380	6/23 (26%)
		leucine-rich repeat	174..197	CDD:275380	4/22 (18%)
		leucine-rich repeat	198..221	CDD:275380	8/22 (36%)
		leucine-rich repeat	222..245	CDD:275380	4/22 (18%)
		leucine-rich repeat	246..269	CDD:275380	5/22 (23%)
		leucine-rich repeat	318..341	CDD:275380	10/46 (22%)
		leucine-rich repeat	342..365	CDD:275380	8/22 (36%)
		leucine-rich repeat	366..391	CDD:275380	4/24 (17%)
		leucine-rich repeat	392..416	CDD:275380	6/24 (25%)
		leucine-rich repeat	417..440	CDD:275380	7/23 (30%)
		leucine-rich repeat	441..464	CDD:275380	10/22 (45%)
		leucine-rich repeat	465..488	CDD:275380	5/22 (23%)
		leucine-rich repeat	489..548	CDD:275380	15/103 (15%)
		leucine-rich repeat	549..572	CDD:275380	8/51 (16%)
		leucine-rich repeat	573..594	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I1829
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050