DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and BRL2

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_178304.1	Gene:	BRL2 / 814726	AraportID:	AT2G01950	Length:	1143	Species:	Arabidopsis thaliana

Alignment Length:	834	Identity:	182/834 - (21%)
Similarity:	314/834 - (37%)	Gaps:	199/834 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 LSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSC------SLDLEY 281
            ||:.|:.:.|..:...::.|.|:...::..|....:.|..:|  ....|..:|      .::|..
plant    25 LSQSSSSDQSSLKTDSLSLLSFKTMIQDDPNNILSNWSPRKS--PCQFSGVTCLGGRVTEINLSG 87

  Fly   282 LDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIV-ALPTELF 345
            ..:|.    ::..|.|.:|..|.||.::.|...:.:...|.....|..|.|||:.:: .||...|
plant    88 SGLSG----IVSFNAFTSLDSLSVLKLSENFFVLNSTSLLLLPLTLTHLELSSSGLIGTLPENFF 148

  Fly   346 AEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS---------------TWID--- 392
            ::.:.:|......||....|...||.:..:||.||||.|.||.               |::|
plant   149 SKYSNLISITLSYNNFTGKLPNDLFLSSKKLQTLDLSYNNITGPISGLTIPLSSCVSMTYLDFSG 213

  Fly   393 -------KNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLEN----IAADTFAP 446
                   .::.:....|..||||:|......|:.|.:|..||.|:|.||:|..    ...||...
plant   214 NSISGYISDSLINCTNLKSLNLSYNNFDGQIPKSFGELKLLQSLDLSHNRLTGWIPPEIGDTCRS 278

  Fly   447 MNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQL--- 508
            :.||        :|.|                   |...||.|::..:||.||.|:|:.|.:
plant   279 LQNL--------RLSY-------------------NNFTGVIPESLSSCSWLQSLDLSNNNISGP 316

  Fly   509 --KTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQI 571
              .|:   ||:...|:.:.|..|:|:                   |::..:|:.     ..:|:|
plant   317 FPNTI---LRSFGSLQILLLSNNLIS-------------------GDFPTSISA-----CKSLRI 354

  Fly   572 LNLARNRIA-VVEPGAFEMTSSIQAVRLDGNEL-NDINGLFSNMPSLLWLNISDNRLESF---DY 631
            .:.:.||.: |:.|......:|::.:||..|.: .:|....|....|..:::|.|.|...   :.
plant   355 ADFSSNRFSGVIPPDLCPGAASLEELRLPDNLVTGEIPPAISQCSELRTIDLSLNYLNGTIPPEI 419

  Fly   632 GHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLIT 696
            |::....|::..:.|....:....|     |||.|                   :.|.||:|.:|
plant   420 GNLQKLEQFIAWYNNIAGEIPPEIG-----KLQNL-------------------KDLILNNNQLT 460

  Fly   697 TVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCD-------C-N 753
            ...|..|.:.:|:..|...:|::|....|...||     ..|....:|.|.||.:       | .
plant   461 GEIPPEFFNCSNIEWVSFTSNRLTGEVPKDFGIL-----SRLAVLQLGNNNFTGEIPPELGKCTT 520

  Fly   754 IDWLQ-KINHITSRQYPRIMDLETIYCKLLNNRE---RAYIPLIEAEPKHFLCTYKTHCFAVCHC 814
            :.||. ..||:|....||:            .|:   :|...|:......|:......|..|...
plant   521 LVWLDLNTNHLTGEIPPRL------------GRQPGSKALSGLLSGNTMAFVRNVGNSCKGVGGL 573

  Fly   815 CEFDACDCE--MTCPTNCTCFHDQTWSTNI---------VECSGAAYSEMPRRVPMDTSELYIDG 868
            .||.....|  :..|:..:|...:.:|..|         :|....:|:::..::|.:..|:.  .
plant   574 VEFSGIRPERLLQIPSLKSCDFTRMYSGPILSLFTRYQTIEYLDLSYNQLRGKIPDEIGEMI--A 636

  Fly   869 NNFVELAGHSFLGR--------KNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHII----- 920
            ...:||:.:...|.        |||.|..|:::.:......:||.|..|:.:.|.:|.:.
plant   637 LQVLELSHNQLSGEIPFTIGQLKNLGVFDASDNRLQGQIPESFSNLSFLVQIDLSNNELTGPIPQ 701

  Fly   921 -----SLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMH 969
                 :|...::.|...|..:.|...|     ||:.|:....|    :|.|..|
plant   702 RGQLSTLPATQYANNPGLCGVPLPECK-----NGNNQLPAGTE----EGKRAKH 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	4/12 (33%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	11/60 (18%)
		leucine-rich repeat	229..249	CDD:275380	3/19 (16%)
		LRR_RI	278..468	CDD:238064	57/219 (26%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	301..386	CDD:290566	26/85 (31%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	8/23 (35%)
		LRR	350..729	CDD:227223	95/417 (23%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	11/49 (22%)
		LRR_RI	<401..626	CDD:238064	57/235 (24%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	9/26 (35%)
		leucine-rich repeat	450..473	CDD:275380	3/22 (14%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	8/24 (33%)
		leucine-rich repeat	521..544	CDD:275380	4/22 (18%)
		leucine-rich repeat	545..566	CDD:275380	2/20 (10%)
		leucine-rich repeat	569..592	CDD:275380	6/23 (26%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	5/23 (22%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	3/20 (15%)
		leucine-rich repeat	685..708	CDD:275380	7/22 (32%)
		leucine-rich repeat	709..728	CDD:275380	4/18 (22%)
		LRR_8	883..943	CDD:290566	15/69 (22%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	5/32 (16%)
		LRR_8	932..990	CDD:290566	10/38 (26%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587
BRL2	NP_178304.1	LRRNT_2	36..75	CDD:285463	6/40 (15%)
		PLN00113	43..1125	CDD:215061	178/816 (22%)
		leucine-rich repeat	80..104	CDD:275380	5/27 (19%)
		leucine-rich repeat	105..153	CDD:275380	13/47 (28%)
		leucine-rich repeat	154..178	CDD:275380	6/23 (26%)
		LRR_RI	163..385	CDD:238064	66/275 (24%)
		leucine-rich repeat	179..205	CDD:275380	9/25 (36%)
		leucine-rich repeat	206..229	CDD:275380	2/22 (9%)
		leucine-rich repeat	230..253	CDD:275380	9/22 (41%)
		leucine-rich repeat	254..278	CDD:275380	9/23 (39%)
		leucine-rich repeat	279..302	CDD:275380	9/49 (18%)
		leucine-rich repeat	303..327	CDD:275380	8/26 (31%)
		leucine-rich repeat	328..376	CDD:275380	12/71 (17%)
		leucine-rich repeat	377..400	CDD:275380	5/22 (23%)
		leucine-rich repeat	401..424	CDD:275380	5/22 (23%)
		leucine-rich repeat	425..448	CDD:275380	5/27 (19%)
		leucine-rich repeat	449..472	CDD:275380	8/41 (20%)
		leucine-rich repeat	473..496	CDD:275380	6/27 (22%)
		leucine-rich repeat	497..518	CDD:275380	5/20 (25%)
		leucine-rich repeat	521..589	CDD:275380	16/79 (20%)
		leucine-rich repeat	590..636	CDD:275380	7/47 (15%)
		leucine-rich repeat	637..660	CDD:275380	3/22 (14%)
		leucine-rich repeat	661..682	CDD:275380	5/20 (25%)
		STKc_IRAK	844..1129	CDD:270968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I1829
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960