DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and slit2

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:XP_021331524.1 Gene:slit2 / 80353 ZFINID:ZDB-GENE-010306-3 Length:1551 Species:Danio rerio


Alignment Length:1638 Identity:344/1638 - (21%)
Similarity:549/1638 - (33%) Gaps:630/1638 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 LQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNI 212
            :::|.:....|.::.:....||:.||.|.|..:.|      ..||..||...:.||||.|:.||:
Zfish    50 VERLDLNANNLTKITKADFAGLKNLRVLQLMENKI------SSIERGAFQDLQELERLRLNRNNL 108

  Fly   213 WSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSL 277
            ..||:.:|...::|..|::|||::|.:....||        ||||                    
Zfish   109 QVLPELLFLGTTKLFRLDLSENQIQGIPRKAFR--------GSTE-------------------- 145

  Fly   278 DLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKI----- 337
             ::.|.:.:|....:....|..||.|.||::|||.||.::..:.:.:..|:...|.||.:     
Zfish   146 -IKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNLLCDCN 209

  Fly   338 --------------------VALP----------------------------------------- 341
                                :|.|                                         
Zfish   210 VAWLSDWLRQRPRLGLYTQCMAPPSLRGHNIAEVQKKEFMCTDFSEGPQSHSSCSVLQCPELCTC 274

  Fly   342 ------------TELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS------ 388
                        ||:.....:.|.|:.|:.|||.::....|:...:|:.:|||.||||.      
Zfish   275 SNNVVDCRGKGLTEIPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSF 339

  Fly   389 ----------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLE 437
                            |.:.|..|.||..|.||.|:.||:..|..:.|.||..|.:|:|..|:|:
Zfish   340 QGLRSLNSLVLYGNKITELPKGLFDGLFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKLQ 404

  Fly   438 NIAADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALIGVHPD 490
            .||..||:.:..:.||.|:.|      .||:|..|      ..:|....|...|.|..:..:...
Zfish   405 TIAKGTFSSLRAIQTLHLAQNPFMCDCHLKWLADYLQDNPIETSGARCTSPRRLANKRIGQIKSK 469

  Fly   491 AFRNCSALQD----------------------------------------LNLNGNQLKTVPLAL 515
            .|| |||.:.                                        ::.:|.:|..:|..:
Zfish   470 KFR-CSAKEQYFIPGIHHINKCVEDYRSKLGGDCFADLACPEKCRCEGTTVDCSGQKLTKIPDHI 533

  Fly   516 RNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIA 580
              .::...:.|..|..||:|.:..                       |:.||.|:.:||:.|:|.
Zfish   534 --PQYTAELRLNNNEFTVLEATGI-----------------------FKKLPQLRKINLSNNKIT 573

  Fly   581 VVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPST--LQWLDL 643
            .:|.|.||..|.:       ||                |.::.||||...|..:...  |:.|.|
Zfish   574 DIEEGTFEGASGV-------NE----------------LILTSNRLEGVHYSMLKGLGGLRTLML 615

  Fly   644 HKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTN 708
            ..||:|.::|.              ||..|         :|:.||.|.|||||::.|..|....:
Zfish   616 RSNRISCVNNG--------------SFTGL---------SSVRLLSLYDNLITSMSPGAFDTLHS 657

  Fly   709 LTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI----DWLQKINHITSRQYP 769
            |:.::|.|                             |||.|:|::    :||:|...:|..  |
Zfish   658 LSTLNLLA-----------------------------NPFNCNCHLAWLGEWLRKKRIVTGN--P 691

  Fly   770 RIMDLETIYCKLLNNRERAY----IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNC 830
            |        |      :..|    ||:.:...:.|.|....         :.::|.....||..|
Zfish   692 R--------C------QSPYFLKEIPIQDVAVQDFACEEGN---------DENSCSPLARCPAEC 733

  Fly   831 TCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNF----VELAGHSFLGRKNLAVLYAN 891
            :|.      ..:|.||......:|:.:|.|.:|||:|||.|    :||:.:     |:|.::..:
Zfish   734 SCL------DTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLELSNY-----KHLTLIDLS 787

  Fly   892 NSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRK 956
            |:.::.:.|.:||.:..||.|.|..|.:..:....|..|::||.|.|..|.||.|.:|:|:.|..
Zfish   788 NNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLKSLRLLSLHGNDIAVIPDGAFKDLSS 852

  Fly   957 LEVLRLDGNRL---MHFE---VWQLSA--NPYLVE------------ISLADNQWSC-----ECG 996
            |..|.|..|.|   .|.:   .|..|.  .|.:..            ::....:::|     .||
Zfish   853 LSHLALGANPLYCDCHMQWLSDWVKSGYKEPGIARCTGPGDMTDKLLLTTPSKKFTCTEVPGTCG 917

  Fly   997 Y----------LARFRNYL-------GQSSEKIIDASRVSCIY--------------------NN 1024
            :          ||:....|       |..|...:|..|.:|.|                    |.
Zfish   918 FPVPGPVDVSILAKCNPCLSNPCKNDGTCSNHPVDFYRCTCPYGFKGQDCEEPIHACISNPCQNG 982

  Fly  1025 ATSVLR--EKN-----------GTKC----------------TLRDGVAHY----------MHTN 1050
            .|..|:  |:|           |.:|                |..||:.:|          .:.|
Zfish   983 GTCHLKDGEENTHWCVCPEGFEGDECEINIDDCEDNDCENNSTCVDGINNYTCLCSPEYTAANNN 1047

  Fly  1051 EIE-GLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMN----FCYKSP--------- 1101
            |:| |.|....:..||               .||.:..|.:.|::.    .|..:|         
Zfish  1048 EVEKGELCEDKLDFCA---------------SELNLCQHDSKCILTAKGFMCECTPGYTGEHCEV 1097

  Fly  1102 RFVDQLDKERPN-----DAYFAYS---------LQDEHFVNQILAQTLENDIGYRLCLHYRDVNI 1152
            .|.|..|.:..|     ||...|:         |..|.....:|.:|..       |.||...|.
Zfish  1098 DFDDCEDNKCKNGAQCIDAVNGYTCVCPEGYSGLFCEFSPPMVLPRTSP-------CDHYDCANG 1155

  Fly  1153 NAYI---TDALIEAAESAK--QFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQ 1212
            ...:   ||.:.:.....:  ....::|.||:    :|..:......|:..:..:          
Zfish  1156 AQCVVKDTDPVCQCLPGYEGVHCERLVSVNFI----NRESFLQIPSNLITEQANI---------- 1206

  Fly  1213 RDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNG----RGNNNKRVVSGCLSGRTPSVNMYA 1273
                                      .|::|....||    :| :|:.:......||        
Zfish  1207 --------------------------SLQIATDEDNGVLLYKG-DNEHIAVELYRGR-------- 1236

  Fly  1274 TSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQL 1338
            ....|.:|:    .||||.|      :..|||:.:                       |:.:..:
Zfish  1237 LRVSYDSGS----YPPSAIY------SVETINDGS-----------------------FHVVELV 1268

  Fly  1339 SKKQQRDLSV-AGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQQIRNNANC 1402
            :|.|...||: .|..|::       :.||.        ||.:||.||.|  :....||       
Zfish  1269 AKDQSLSLSIDGGSPKSI-------NTANS--------PSPVPSPAPLY--LGGLPQQ------- 1309

  Fly  1403 ECVNLGTAKRAAGKNPAS---------------GLPSSFSSNFVPPGGASYNCKKS------CSC 1446
              ..|.:.::.:|:|.:|               .|........|.||  ...|::|      |..
Zfish  1310 --SGLASLRQGSGRNGSSFHGCIRNLYINDQLQDLTQFLLQEGVVPG--CQPCQRSMCAHGQCHA 1370

  Fly  1447 IGDDELLCSCGGG 1459
            .|.....|.|..|
Zfish  1371 TGQSSFSCECEAG 1383

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/22 (18%)
LRR_8 171..236 CDD:290566 24/64 (38%)
leucine-rich repeat 172..201 CDD:275380 9/28 (32%)
leucine-rich repeat 202..278 CDD:275380 22/75 (29%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 68/301 (23%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 29/162 (18%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 8/100 (8%)
LRR 350..729 CDD:227223 109/454 (24%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 13/46 (28%)
LRR_RI <401..626 CDD:238064 61/276 (22%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 9/22 (41%)
leucine-rich repeat 450..473 CDD:275380 9/34 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 3/59 (5%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 2/21 (10%)
leucine-rich repeat 616..637 CDD:275380 6/20 (30%)
leucine-rich repeat 638..662 CDD:275380 7/23 (30%)
leucine-rich repeat 663..684 CDD:275380 3/20 (15%)
leucine-rich repeat 685..708 CDD:275380 10/22 (45%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 18/59 (31%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
LRR_8 932..990 CDD:290566 20/77 (26%)
leucine-rich repeat 933..956 CDD:275380 11/22 (50%)
TIR 1114..1247 CDD:214587 20/146 (14%)