DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and tlr4al

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001315534.1 Gene:tlr4al / 795671 ZFINID:ZDB-GENE-090507-2 Length:816 Species:Danio rerio


Alignment Length:1010 Identity:215/1010 - (21%)
Similarity:374/1010 - (37%) Gaps:308/1010 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 IVALPTELFAEQAKIIQEVY--LQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGL 399
            |:..|........:||:.::  ....::|.:..::.|:   :|.||.|.|.:  .|:.|..|   
Zfish    10 IIYFPIGAGQSCTEIIENLHYSCMGRNLSYIPSRIPSS---VQTLDFSFNDL--KWLKKTVF--- 66

  Fly   400 IRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLD 464
                              .:|:.|..|.:......|:||   |.|..:.||.||.|:.|.:.|..
Zfish    67 ------------------PVFTFLRVLDLSRCHIRQIEN---DAFYNVKNLTTLFLTGNPIIYFA 110

  Fly   465 AYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGN--QLKTVPLALRNMRHLRTVDLG 527
            ...||.||.|..|.|.:..|..:..: ..|.:.||:||:..|  |..|:|..:...:....:||.
Zfish   111 PGCLNTLYNLQRLVLVDIGLESLQLN-INNLTKLQELNVGTNYIQSMTLPPFMSTFKDFSLLDLH 174

  Fly   528 ENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHT--FRDLPNLQILNLARNRIAVVEPGAFEMT 590
            .|.|:::.                       |.||  .|::.....|.|:||.:..:|||:|:  
Zfish   175 ANNISIIR-----------------------TNHTVVLREIGKNMTLILSRNPLLHIEPGSFK-- 214

  Fly   591 SSIQAVRLD-----------GNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLD-- 642
             .:..|.||           ...||.::||  |:..|::....|      |....||.|.:.|  
Zfish   215 -GVHLVELDIRSTFVSFASKKQGLNGLHGL--NVTRLMFGMYKD------DPKLYPSDLDYFDGL 270

  Fly   643 --LH--------KNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLIT- 696
              :|        |.||....|.|  ...:....:.|....::.||........||..:|..|.| 
Zfish   271 CSIHFYEAYYYMKERLDWKMNIF--RCMINATVVVVKGGVIRVIGYVPFHKIKELYLINTQLYTV 333

  Fly   697 ---------TVDPDTFMHKT-----------NLTRVDLYANQIT----TLDIKSLRILPVWEHRA 737
                     |::...|.|.:           .|..|||.:||||    .:|:             
Zfish   334 PGKQLSHIRTLEKFVFTHNSATQVEKFLDMPKLQYVDLNSNQITLQSCCIDV------------- 385

  Fly   738 LPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRI-MD------LETI------YCKLL------- 782
                 :.|.|           :|.::.....|:| :|      ||::      :.|||       
Zfish   386 -----LSGTP-----------QIRYLNLSLNPQISLDKGGFEGLESLEILDFHHTKLLGIGSFTL 434

  Fly   783 --NNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVEC 845
              |.:...|:.:          :|.:..|                  .|..||:..: |..:::.
Zfish   435 LSNLKNLRYLDI----------SYSSVTF------------------VNVYCFYGLS-SLKVLKM 470

  Fly   846 SGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLL 910
            :|.::..       |.:....:...|:|          :|.:.|.   :|..|:.|:|..|:||.
Zfish   471 AGNSFQG-------DVANYLFNNLTFLE----------HLDISYC---HVIEIHLTSFKNLQRLR 515

  Fly   911 ILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQL 975
            .|:|..|:::|::.....||:.|...|:..|.|.:|   ...:|:||.         |:...:.|
Zfish   516 HLNLRGNNLMSIDFLTDPNLKQLTTFYVNKNSITTI---PLDILQKLP---------MNLSEFDL 568

  Fly   976 SANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKC-TL 1039
            |.||.           .|.|.                 ....:..|.|| ..||::.....| |:
Zfish   569 SFNPI-----------DCSCS-----------------QTDFMLWIINN-QRVLKQPENILCKTI 604

  Fly  1040 RDG---------VAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMN 1095
            ...         :.|.::..:       |::|...|...|.::..:..||.:.         .:.
Zfish   605 SPNSDFRVTDFDIDHCVYKKK-------LIIALLVFCVVFIVVLSILVYRFQF---------YLR 653

  Fly  1096 FC------YKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDI-GYRLCLHYRDVNIN 1153
            :|      |:||.     .:|...||:..:|..||.:|...|.:.|||.: ..:||||.||....
Zfish   654 YCWILLRGYRSPG-----QQECSYDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAG 713

  Fly  1154 AYITDALI-EAAESAKQFVLVLSKNFLYNEWSRFEYKSALHE-LVKRRKRVVFILYGDLPQRDID 1216
            ..|...:| |....:::.::|:|::|:.:.|.|||::.|... :|:|...::.|:..|:.:|...
Zfish   714 KSIASNIIDEGIMGSRKIIVVVSQHFIDSAWCRFEFELAQSRFVVERNANIIIIILEDVAERKTK 778

  Fly  1217 --MDMRHYLRTSTCIEW-----DDKKFWQKLRLAL 1244
              :.:..:|:.:|.::|     .:.:||.:||.|:
Zfish   779 KVLGLHKHLKKNTYLKWSRDPLSNMRFWIRLRKAI 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380
LRR 299..654 CDD:443914 81/345 (23%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380 2/12 (17%)
leucine-rich repeat 352..375 CDD:275380 3/24 (13%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
leucine-rich repeat 402..425 CDD:275380 2/22 (9%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 9/22 (41%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..518 CDD:275380 8/21 (38%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 4/22 (18%)
leucine-rich repeat 569..592 CDD:275380 8/22 (36%)
leucine-rich repeat 593..615 CDD:275380 8/32 (25%)
leucine-rich repeat 616..637 CDD:275380 4/20 (20%)
leucine-rich repeat 638..662 CDD:275380 8/35 (23%)
LRR_8 662..719 CDD:404697 16/77 (21%)
leucine-rich repeat 663..684 CDD:275380 3/20 (15%)
leucine-rich repeat 685..708 CDD:275380 8/43 (19%)
leucine-rich repeat 709..728 CDD:275380 9/22 (41%)
LRR <863..>990 CDD:443914 30/126 (24%)
leucine-rich repeat 885..908 CDD:275380 7/22 (32%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 40/141 (28%)
tlr4alNP_001315534.1 leucine-rich repeat 28..47 CDD:275380 1/18 (6%)
LRR <36..>205 CDD:443914 54/221 (24%)
leucine-rich repeat 48..71 CDD:275380 9/45 (20%)
leucine-rich repeat 72..95 CDD:275380 7/25 (28%)
leucine-rich repeat 96..119 CDD:275380 9/22 (41%)
leucine-rich repeat 120..142 CDD:275380 5/22 (23%)
leucine-rich repeat 143..168 CDD:275380 8/24 (33%)
leucine-rich repeat 170..196 CDD:275380 8/48 (17%)
leucine-rich repeat 321..343 CDD:275380 5/21 (24%)
LRR <328..617 CDD:443914 74/407 (18%)
leucine-rich repeat 366..391 CDD:275380 11/53 (21%)
leucine-rich repeat 392..415 CDD:275380 5/22 (23%)
leucine-rich repeat 416..440 CDD:275380 4/23 (17%)
leucine-rich repeat 441..464 CDD:275380 6/51 (12%)
leucine-rich repeat 465..489 CDD:275380 2/30 (7%)
leucine-rich repeat 490..513 CDD:275380 8/35 (23%)
leucine-rich repeat 514..537 CDD:275380 7/22 (32%)
leucine-rich repeat 538..562 CDD:275380 8/35 (23%)
TIR 672..813 CDD:214587 39/140 (28%)
Blue background indicates that the domain is not in the aligned region.

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