Protein Alignment Toll-6 and lrrc15

DIOPT Version :9

• Sequence 1: NP_001246765.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: NP_001074151.1
• Gene: lrrc15 / 791200
• ZFINID: ZDB-GENE-031113-8
• Length: 564
• Species: Danio rerio
• Alignment Length: 581
• Identity: 143/581 - (24%)
• Similarity: 238/581 - (40%)
• Gaps: 152/581 - (26%)

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPT-NGSTESTSTTESAKKSSSSSTSCSL 277
            |.|::..|.::::.....|      |.|:..   ...|| |....|.::.:|.|.|...:.:.:|
Zfish    20 SCPESCQCQVTKIVCQGFS------VKEIPL---PMPPTINALVISNTSIQSLKPSDFQTFAETL 75

  Fly   278 DLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPT 342
            .| ::..:.|...|.| :.|.....|..|..:...::.:.|.....|..|..|.||.||:..||:
Zfish    76 TL-FVAKNSNITEVEP-HTFDQAFNLNALGFSGTMLTSLPDNLFQNLTALTTLTLSGNKLEVLPS 138

  Fly   343 ELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNL 407
            .|....|. :.::.|..|.:|.|:...|..||||:.|.|..|.|..  :..:||.||..|..|.|
Zfish   139 SLLTPLAN-VNKLDLSKNLLSSLSEDAFRGLDQLEMLMLQRNSIKQ--LHSSTFQGLSHLRSLFL 200

  Fly   408 SHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLY 472
            ..|:||.:...:|.||..|::|:|:.|::|.:.|:.||.:.||..|.||.|:|..|.:.....|.
Zfish   201 QQNQLTDIPAGLFDDLVNLEVLHLQDNKIEQLPANLFAKVQNLKKLYLSSNRLSLLPSGIFLSLP 265

  Fly   473 VLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDS 537
            .|:.:||.:|.|..:.|:.| ...|||:|.|.                       :|::|.:|
Zfish   266 NLTHISLYDNRLSRLMPETF-GTMALQELWLY-----------------------DNLLTHLE-- 304

  Fly   538 AFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNE 602
                              ||:    |.:|.|:::|.::||||..:.||||.....::.|.|..|.
Zfish   305 ------------------ENV----FSNLTNIRLLVISRNRIQYISPGAFNGLKELKEVSLHTNR 347

  Fly   603 LNDIN-GLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTL 666
            |.:|. |:|..:|:|..::|.:|:::     .:|..|                  ||...:|..|
Zfish   348 LTNIEPGIFRGLPNLANISIENNQIK-----QIPIQL------------------LDGVSRLSLL 389

  Fly   667 DVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILP 731
            ::..|.||.: |....|::.::   :|:|        :|:
Zfish   390 EMQNNSLQNL-PKDFLNTLSIV---ENVI--------LHE------------------------- 417

  Fly   732 VWEHRALPEFYIGGNPFTCDCNI----DWLQKINHITSRQYPRIMDLETIYCKL---LNNR 785
                          ||:.||.:|    .||       |:...::.:|..:.|..   ||.|
Zfish   418 --------------NPWRCDQDIIPFWGWL-------SQHSEKVKNLSLVMCSSPPPLNGR 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	4/21 (19%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	13/64 (20%)
		leucine-rich repeat	229..249	CDD:275380	3/19 (16%)
		LRR_RI	278..468	CDD:238064	61/189 (32%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	301..386	CDD:290566	26/84 (31%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	97/379 (26%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	9/24 (38%)
		LRR_RI	<401..626	CDD:238064	66/225 (29%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	4/19 (21%)
		leucine-rich repeat	521..544	CDD:275380	3/22 (14%)
		leucine-rich repeat	545..566	CDD:275380	3/20 (15%)
		leucine-rich repeat	569..592	CDD:275380	9/22 (41%)
		leucine-rich repeat	593..615	CDD:275380	7/22 (32%)
		leucine-rich repeat	616..637	CDD:275380	4/20 (20%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	6/20 (30%)
		leucine-rich repeat	685..708	CDD:275380	3/22 (14%)
		leucine-rich repeat	709..728	CDD:275380	0/18 (0%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
lrrc15	NP_001074151.1	LRRNT	21..48	CDD:214470	5/35 (14%)
		leucine-rich repeat	53..73	CDD:275380	4/19 (21%)
		LRR_RI	<163..253	CDD:238064	36/91 (40%)
		LRR_8	170..229	CDD:290566	23/60 (38%)
		leucine-rich repeat	171..194	CDD:275380	9/24 (38%)
		leucine-rich repeat	195..218	CDD:275380	9/22 (41%)
		LRR_8	218..277	CDD:290566	21/58 (36%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR_4	241..280	CDD:289563	14/38 (37%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		leucine-rich repeat	267..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	11/69 (16%)
		LRR_8	312..372	CDD:290566	21/59 (36%)
		leucine-rich repeat	314..337	CDD:275380	9/22 (41%)
		leucine-rich repeat	338..361	CDD:275380	7/22 (32%)
		leucine-rich repeat	362..385	CDD:275380	7/45 (16%)
		TPKR_C2	418..467	CDD:301599	13/47 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010