DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and Lrrtm1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001349038.1	Gene:	Lrrtm1 / 74342	MGIID:	2389173	Length:	522	Species:	Mus musculus

Alignment Length:	421	Identity:	102/421 - (24%)
Similarity:	178/421 - (42%)	Gaps:	91/421 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 NIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSC 275
            |:...|.|    ||.|..|::..|.|.::       |:.:.|.
Mouse    56 NLTEAPHN----LSGLLGLSLRYNSLSEL-------RAGQFTG---------------------- 87

  Fly   276 SLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVAL 340
            .:.|.:|.:.||....:..:.|..|||::.|::::|.|:.:|:.....:.||:.::||.||:.||
Mouse    88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQAL 152

  Fly   341 PTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLL 405
            ..:||....| :..::::.|:|..:..::|.:...|:.||:..||:.|  :.:|:|.||.:|..|
Mouse   153 APDLFHGLRK-LTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKS--LARNSFAGLFKLTEL 214

  Fly   406 NLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNG 470
            :|.||.|.|:....|..|.:|..|.||.|::. |...:...:.||..:.||.|:::|::.:....
Mouse   215 HLEHNDLIKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFET 278

  Fly   471 LYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVME 535
            :..|..|.||:|.|..:.|....:..:|..:.|.||                ..|.|.|:..:..
Mouse   279 VPYLQTLQLDSNRLTYIEPRILNSWKSLTSITLAGN----------------LWDCGRNVCALAS 327

  Fly   536 -DSAFKG-------------------LGNLYGLRLIGNYLENITMHTFRDLPNLQILNLA-RNRI 579
             .|.|:|                   |..:|...|..:..|..:.|         :|::| .||.
Mouse   328 WLSNFQGRYDANLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGH---------LLSVAVTNRS 383

  Fly   580 AVVEPGAFEMTSSIQAVRLDGNELNDINGLF 610
            .:..|      .|.....:||.|.:|  |.|
Mouse   384 DLTPP------ESSATTLVDGGEGHD--GTF 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	8/24 (33%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	11/66 (17%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	57/189 (30%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	301..386	CDD:290566	24/84 (29%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	69/282 (24%)
		leucine-rich repeat	352..375	CDD:275380	3/22 (14%)
		leucine-rich repeat	376..401	CDD:275380	10/24 (42%)
		LRR_RI	<401..626	CDD:238064	55/231 (24%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	5/22 (23%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	4/19 (21%)
		leucine-rich repeat	521..544	CDD:275380	7/42 (17%)
		leucine-rich repeat	545..566	CDD:275380	4/20 (20%)
		leucine-rich repeat	569..592	CDD:275380	5/23 (22%)
		leucine-rich repeat	593..615	CDD:275380	6/18 (33%)
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Lrrtm1	NP_001349038.1	LRR 1	64..87		7/29 (24%)
		LRR	<75..>315	CDD:227223	72/288 (25%)
		LRR 2	89..111		5/21 (24%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		LRR 3	112..135		7/22 (32%)
		leucine-rich repeat	115..138	CDD:275380	4/22 (18%)
		LRR 4	136..159		10/22 (45%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		LRR 5	161..183		4/22 (18%)
		leucine-rich repeat	163..186	CDD:275380	3/22 (14%)
		LRR 6	184..207		8/24 (33%)
		leucine-rich repeat	187..210	CDD:275380	10/24 (42%)
		LRR 7	209..231		8/21 (38%)
		leucine-rich repeat	211..234	CDD:275380	9/22 (41%)
		LRR 8	233..255		6/22 (27%)
		leucine-rich repeat	235..257	CDD:275380	6/22 (27%)
		LRR 9	256..278		6/21 (29%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		LRR 10	280..302		7/21 (33%)
		leucine-rich repeat	282..300	CDD:275380	7/17 (41%)
		leucine-rich repeat	306..318	CDD:275378	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910