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Protein Alignment Toll-6 and TLR5

DIOPT Version :10

Sequence 1:	NP_524081.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_003259.2	Gene:	TLR5 / 7100	HGNCID:	11851	Length:	858	Species:	Homo sapiens

Alignment Length:	1038	Identity:	240/1038 - (23%)
Similarity:	392/1038 - (37%)	Gaps:	318/1038 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 SCSLD--------------------LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIAD 318
            |||.|                    .|.|.:|.|....:.|:.|..|.:|::|.:.:....:..|
Human    23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTID 87

  Fly   319 K-ALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQ-EVYLQNNSISVLNPQLFSNLDQLQALDL 381
            | |...|.||:||:|.|:||..|..:.|.....:.: .:|....|.:||....|.||..|..|||
Human    88 KEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152

  Fly   382 SMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAP 446
            |.|||.|.:              |:.|..||..|:...||   :.||..:..::||.:...|
Human   153 SKNQIRSLY--------------LHPSFGKLNSLKSIDFS---SNQIFLVCEHELEPLQGKT--- 197

  Fly   447 MNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQ---- 507
                    ||...|      |.|.||  |.:|:|    .|...:.||| ..|:.|:::||.
Human   198 --------LSFFSL------AANSLY--SRVSVD----WGKCMNPFRN-MVLEILDVSGNGWTVD 241

  Fly   508 ---------LKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGL--GNLYGLRLIGNYLENITMH 561
                     .|:...:|....|:.....|.:.|...:.:.|.||  .::..|.|...::.::...
Human   242 ITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSR 306

  Fly   562 TFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRL 626
            .|..|.:|::||||.|:|..:...||....::|.:.|..|.|.::..  ||.
Human   307 VFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYS--SNF------------- 356

  Fly   627 ESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLN 691
                || :|. :.::||.||.::.:.::.....| ||||||:..|.|..|  ..|| ||..:||:
Human   357 ----YG-LPK-VAYIDLQKNHIAIIQDQTFKFLE-KLQTLDLRDNALTTI--HFIP-SIPDIFLS 411

  Fly   692 DNLITTVDPDTFMHKTNLTR--VDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI 754
            .|.:.|      :.|.|||.  :.|..|::..|||                             :
Human   412 GNKLVT------LPKINLTANLIHLSENRLENLDI-----------------------------L 441

  Fly   755 DWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDA 819
            .:|.::.|:..               |:.|:.|                             |.:
Human   442 YFLLRVPHLQI---------------LILNQNR-----------------------------FSS 462

  Fly   820 CDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKN 884
            |.            .|||.|.|                 ....:|:: |.|.::||..:
Human   463 CS------------GDQTPSEN-----------------PSLEQLFL-GENMLQLAWET------ 491

  Fly   885 LAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANG 949
                        .:....|.||..|.:|:|..|::.||....|.:|..||.|.|.||::..:::.
Human   492 ------------ELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHN 544

  Fly   950 SFQMLRKLEVLRLDGNRLMHFEVWQLSANP-YLVEISLAD---NQWSCECGYLARFRNYLGQSSE 1010
              .:...||:|.:..|:|       |:.|| ..|.:|:.|   |::.||| .|:.|.|:|..::.
Human   545 --DLPANLEILDISRNQL-------LAPNPDVFVSLSVLDITHNKFICEC-ELSTFINWLNHTNV 599

  Fly  1011 KII-DASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNE-------IEGL-LPLLLVATCAF 1066
            .|. ..:.:.|:|.::.|              ||:.:..:.|       ::.| ..|.:|.|...
Human   600 TIAGPPADIYCVYPDSFS--------------GVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTL 650

  Fly  1067 VAFFGLI-----FGLFCYRHELKIWAHSTNCLMNFCYKSPR---FVDQLDKERPN----DAYFAY 1119
            ..|...|     |..||:                .|||:.:   |.|......|:    |||..:
Human   651 TLFLMTILTVTKFRGFCF----------------ICYKTAQRLVFKDHPQGTEPDMYKYDAYLCF 699

  Fly  1120 SLQDEHFVNQILAQTLENDIG----YRLCLHYRDV----NINAYITDALIEAAESAKQFVLVLSK 1176
            |.:|..:|...|.:.|:....    :.||...||.    |..|.|.||:    .::::.|.::|:
Human   700 SSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAI----WNSRKIVCLVSR 760

  Fly  1177 NFLYNEW--SRFEYKS--ALHELVKRRKRVVFILYGDLPQRDI--DMDMRHYLRTSTCIEWDD 1233
            :||.:.|  ..|.|..  .|.:|   ...::.::.|.|.|..:  ...:|.:::....:.|.:
Human   761 HFLRDGWCLEAFSYAQGRCLSDL---NSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPE 820

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.