DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and TLR4

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:1092 Identity:247/1092 - (22%)
Similarity:404/1092 - (36%) Gaps:345/1092 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 NIWSLPDNI-FCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTS 274
            |.:.:|||: |.|.:    |::|.|.|:.:              ||....|..|           
Human    44 NFYKIPDNLPFSTKN----LDLSFNPLRHL--------------GSYSFFSFPE----------- 79

  Fly   275 CSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVA 339
                |:.||:|..:...:....:.:|..|..|.:..|.|..:|..|.|||.:||       |:||
Human    80 ----LQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQ-------KLVA 133

  Fly   340 LPTELFAEQ------AKIIQEVYLQNNSI-SVLNPQLFSNLDQLQALDLSMNQITSTW-IDKNTF 396
            :.|.|.:.:      .|.::|:.:.:|.| |...|:.||||..|:.||||.|:|.|.: .|... 
Human   134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRV- 197

  Fly   397 VGLIRLVLLN----LSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSH 457
              |.::.|||    ||.|.:..::|..|.:: .|..|.||:|         |..:|.:.|.:   
Human   198 --LHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLTLRNN---------FDSLNVMKTCI--- 247

  Fly   458 NKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLR 522
                    ..|.||.|       :..::|    .|||         .||..|             
Human   248 --------QGLAGLEV-------HRLVLG----EFRN---------EGNLEK------------- 271

  Fly   523 TVDLGENMITVMEDSAFKGLGNL----YGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVE 583
                       .:.||.:||.||    :.|..:..||::| :..|..|.|:...:|....|..|:
Human   272 -----------FDKSALEGLCNLTIEEFRLAYLDYYLDDI-IDLFNCLTNVSSFSLVSVTIERVK 324

  Fly   584 PGAFEMTSSIQAVRLDGNELNDINGLFSNMP-----SLLWLNISDNR-LESFDYGHVPSTLQWLD 642
            .  |......|.:.|       :|..|...|     ||..|..:.|: ..:|....:|| |::||
Human   325 D--FSYNFGWQHLEL-------VNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPS-LEFLD 379

  Fly   643 LHKNRLS-----SLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDT 702
            |.:|.||     |.|: ||..|   |:.||:|||              .::.::.|.        
Human   380 LSRNGLSFKGCCSQSD-FGTTS---LKYLDLSFN--------------GVITMSSNF-------- 418

  Fly   703 FMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQ 767
                       |...|:..||.:...:      :.:.||                          
Human   419 -----------LGLEQLEHLDFQHSNL------KQMSEF-------------------------- 440

  Fly   768 YPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTC 832
                    :::..|.|        ||..:..|      ||                         
Human   441 --------SVFLSLRN--------LIYLDISH------TH------------------------- 458

  Fly   833 FHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVL-YANNSNVA 896
                         :..|::.:                         |.|..:|.|| .|.||...
Human   459 -------------TRVAFNGI-------------------------FNGLSSLEVLKMAGNSFQE 485

  Fly   897 HIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLR 961
            :.....|:.|:.|..|.|....:..|....|::|.:|:.|.:..|...|:....::.|..|:||.
Human   486 NFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLD 550

  Fly   962 LDGNRLMHFEVWQLSANP-YLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNA 1025
            ...|.:|..:..:|...| .|..::|..|.::|.|.:.: |..::....:.:::..|:.|    |
Human   551 YSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQS-FLQWIKDQRQLLVEVERMEC----A 610

  Fly  1026 TSVLREKNGTKCTLRDGVAHYMHTNEI-EGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHS 1089
            |.  .:|.|.. .|...:...|:...| ..:|.:|:|:..|.:.:              |.:.|.
Human   611 TP--SDKQGMP-VLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVY--------------KFYFHL 658

  Fly  1090 TNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDI-GYRLCLHYRDVNIN 1153
              .|:..|.|..|      .|...||:..||.|||.:|...|.:.||..: .::|||||||....
Human   659 --MLLAGCIKYGR------GENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPG 715

  Fly  1154 AYITDALI-EAAESAKQFVLVLSKNFLYNEWSRFEYKSA-LHELVKRRKRVVFILYGDLPQRDID 1216
            ..|...:| |....:::.::|:|::|:.:.|..|||:.| ..:.:..|..::||:...:.:..:.
Human   716 VAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR 780

  Fly  1217 MDMRHY--LRTSTCIEWDDKK-----FWQKLRLALPLPNGRGNNNKRVVSGC 1261
            ..:..|  |..:|.:||:|..     ||::||.|| |.....|....|.:||
Human   781 QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKAL-LDGKSWNPEGTVGTGC 831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566 9/25 (36%)
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 14/67 (21%)
leucine-rich repeat 229..249 CDD:275380 4/19 (21%)
LRR_RI 278..468 CDD:238064 57/201 (28%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
LRR_8 301..386 CDD:290566 32/91 (35%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 7/28 (25%)
LRR 350..729 CDD:227223 99/399 (25%)
leucine-rich repeat 352..375 CDD:275380 9/23 (39%)
leucine-rich repeat 376..401 CDD:275380 10/25 (40%)
LRR_RI <401..626 CDD:238064 53/238 (22%)
leucine-rich repeat 402..425 CDD:275380 8/26 (31%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 4/22 (18%)
leucine-rich repeat 474..497 CDD:275380 4/22 (18%)
leucine-rich repeat 498..518 CDD:275380 3/19 (16%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 6/24 (25%)
leucine-rich repeat 569..592 CDD:275380 4/22 (18%)
leucine-rich repeat 593..615 CDD:275380 5/26 (19%)
leucine-rich repeat 616..637 CDD:275380 5/21 (24%)
leucine-rich repeat 638..662 CDD:275380 12/28 (43%)
leucine-rich repeat 663..684 CDD:275380 6/20 (30%)
leucine-rich repeat 685..708 CDD:275380 1/22 (5%)
leucine-rich repeat 709..728 CDD:275380 4/18 (22%)
LRR_8 883..943 CDD:290566 17/60 (28%)
leucine-rich repeat 885..908 CDD:275380 8/23 (35%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 14/58 (24%)
leucine-rich repeat 933..956 CDD:275380 5/22 (23%)
TIR 1114..1247 CDD:214587 44/142 (31%)
TLR4NP_612564.1 LRR_RI 55..>195 CDD:238064 48/179 (27%)
LRR 1 55..76 7/38 (18%)
leucine-rich repeat 56..79 CDD:275378 8/40 (20%)
LRR_8 57..114 CDD:290566 16/89 (18%)
LRR 2 79..100 5/35 (14%)
leucine-rich repeat 80..103 CDD:275378 5/22 (23%)
LRR_8 102..187 CDD:290566 32/91 (35%)
LRR 3 103..124 6/20 (30%)
leucine-rich repeat 104..127 CDD:275378 9/22 (41%)
LRR 4 127..148 7/27 (26%)
leucine-rich repeat 128..176 CDD:275378 17/54 (31%)
leucine-rich repeat 130..151 CDD:275380 5/20 (25%)
LRR 5 151..172 5/20 (25%)
LRR_RI 152..456 CDD:238064 104/467 (22%)
LRR 6 176..199 9/25 (36%)
leucine-rich repeat 177..190 CDD:275378 7/12 (58%)
leucine-rich repeat 195..224 CDD:275380 8/31 (26%)
LRR 7 205..225 6/19 (32%)
LRR 8 227..247 8/28 (29%)
LRR 9 331..351 5/26 (19%)
LRR 10 352..373 5/20 (25%)
leucine-rich repeat 353..374 CDD:275380 4/20 (20%)
LRR_RI <372..581 CDD:238064 66/363 (18%)
LRR 11 374..394 9/20 (45%)
LRR_8 399..458 CDD:290566 19/148 (13%)
LRR 12 400..422 9/57 (16%)
leucine-rich repeat 401..423 CDD:275380 8/54 (15%)
LRR 13 423..444 5/60 (8%)
leucine-rich repeat 424..448 CDD:275380 5/63 (8%)
LRR_8 447..508 CDD:290566 20/137 (15%)
LRR 14 448..456 3/15 (20%)
leucine-rich repeat 449..472 CDD:275380 8/91 (9%)
LRR 15 472..495 7/22 (32%)
leucine-rich repeat 473..497 CDD:275380 8/23 (35%)
LRR 16 497..518 5/20 (25%)
leucine-rich repeat 498..521 CDD:275380 6/22 (27%)
LRR_8 520..581 CDD:290566 15/60 (25%)
LRR 17 521..542 4/20 (20%)
LRR 18 545..565 5/19 (26%)
leucine-rich repeat 546..570 CDD:275380 7/23 (30%)
LRRCT 579..625 CDD:214507 11/53 (21%)
TIR 674..815 CDD:214587 42/140 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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