DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and TLR2

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001305716.1 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens


Alignment Length:1068 Identity:222/1068 - (20%)
Similarity:373/1068 - (34%) Gaps:391/1068 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   265 AKKSSSSSTSCSLDLEYL-DVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQ 328
            :|:.||:..|.|.|...: ..|......:|:   |....::.|.::||.|:.|::..|....|||
Human    18 SKEESSNQASLSCDRNGICKGSSGSLNSIPS---GLTEAVKSLDLSNNRITYISNSDLQRCVNLQ 79

  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMN---QITSTW 390
            .|.|:|                         |.|:.:....||:|..|:.||||.|   .::|:|
Human    80 ALVLTS-------------------------NGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSW 119

  Fly   391 IDKNTFVGLIRLVLLNLSHNKLTKL-EPEIFSDLYTLQILNLRH-NQLENIAADTFAPMNNLHTL 453
                 |..|..|..|||..|....| |..:||.|..||||.:.: :....|....||.:..|..|
Human   120 -----FKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEEL 179

  Fly   454 LLSHNKLKYLDAYALNGLYVLSLLSL---DNNALIGVHPDAFRN--CSALQDLNLNGNQLKTVPL 513
            .:..:.|:..:..:|..:..:|.|.|   .:..|:.:..|...:  |..|:|.:|:......:..
Human   180 EIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELST 244

  Fly   514 ALRN-------MRHLRTVDLGENMITVM--------------EDSAFKGLGNLYGLRLIGNYLEN 557
            ...|       .|:::..|  |::..||              :|....|:||             
Human   245 GETNSLIKKFTFRNVKITD--ESLFQVMKLLNQISGLLELEFDDCTLNGVGN------------- 294

  Fly   558 ITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNEL-NDINGLFSNMPSLLWLNI 621
                 ||          |.:...|::||..| |.:|:.:.:....| .|::.|:|....:..:.:
Human   295 -----FR----------ASDNDRVIDPGKVE-TLTIRRLHIPRFYLFYDLSTLYSLTERVKRITV 343

  Fly   622 SDNRLESFDYGHVP-------STLQWLDLHKNRL--SSLSNRFGLDSELKLQTLDVSFNQLQRIG 677
            .::::..     ||       .:|::|||.:|.:  ..|.|....|:...||||.:..|.|..:.
Human   344 ENSKVFL-----VPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLE 403

  Fly   678 PSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFY 742
            .:.                    :|.:...|||.:|:..|..                .::||  
Human   404 KTG--------------------ETLLTLKNLTNIDISKNSF----------------HSMPE-- 430

  Fly   743 IGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTH 807
                  ||                |:|..|       |.||                 |.:.:.|
Human   431 ------TC----------------QWPEKM-------KYLN-----------------LSSTRIH 449

  Fly   808 CFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFV 872
            ....|                                            :|              
Human   450 SVTGC--------------------------------------------IP-------------- 456

  Fly   873 ELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELY 937
                      |.|.:|..:|:|:                      ::.||      ||..|:|||
Human   457 ----------KTLEILDVSNNNL----------------------NLFSL------NLPQLKELY 483

  Fly   938 LQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFR 1002
            :..||:.::.:.|  :|..|.||::..|.:..|...||.:...|..:....|.:.|.|.:|:..:
Human   484 ISRNKLMTLPDAS--LLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQ 546

  Fly  1003 --------------NYLGQSSEKI----IDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHT 1049
                          |||..|...:    :...|:|....:.|:::   :|..|.|          
Human   547 EQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALV---SGMCCAL---------- 598

  Fly  1050 NEIEGLLPLLLVATCAFVAFFGLIFGLFCYR-HEL----KIWAHSTNCLM-----------NFCY 1098
                    .||:          |:.|:.|:| |.|    .:||    .|.           |.||
Human   599 --------FLLI----------LLTGVLCHRFHGLWYMKMMWA----WLQAKRKPRKAPSRNICY 641

  Fly  1099 KSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLEN-DIGYRLCLHYRDVNINAYITDALIE 1162
                           ||:.:||.:|.::|..::.|.||| :..::||||.||.....:|.|.:|:
Human   642 ---------------DAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIID 691

  Fly  1163 AAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGD------LPQRDIDMDMRH 1221
            :.|.:.:.|.|||:||:.:||.::|...:...|.........::..:      :|||  ...:|.
Human   692 SIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQR--FCKLRK 754

  Fly  1222 YLRTSTCIEW--DDKK---FWQKLRLAL 1244
            .:.|.|.:||  |:.:   ||..||.|:
Human   755 IMNTKTYLEWPMDEAQREGFWVNLRAAI 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 5/12 (42%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 51/195 (26%)
leucine-rich repeat 279..302 CDD:275380 3/23 (13%)
LRR_8 301..386 CDD:290566 23/87 (26%)
leucine-rich repeat 303..326 CDD:275380 6/22 (27%)
leucine-rich repeat 327..350 CDD:275380 5/22 (23%)
LRR 350..729 CDD:227223 90/419 (21%)
leucine-rich repeat 352..375 CDD:275380 5/22 (23%)
leucine-rich repeat 376..401 CDD:275380 10/27 (37%)
LRR_RI <401..626 CDD:238064 53/253 (21%)
leucine-rich repeat 402..425 CDD:275380 10/23 (43%)
leucine-rich repeat 426..449 CDD:275380 7/23 (30%)
leucine-rich repeat 450..473 CDD:275380 4/22 (18%)
leucine-rich repeat 474..497 CDD:275380 6/27 (22%)
leucine-rich repeat 498..518 CDD:275380 4/26 (15%)
leucine-rich repeat 521..544 CDD:275380 6/36 (17%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 5/22 (23%)
leucine-rich repeat 616..637 CDD:275380 2/27 (7%)
leucine-rich repeat 638..662 CDD:275380 8/25 (32%)
leucine-rich repeat 663..684 CDD:275380 6/20 (30%)
leucine-rich repeat 685..708 CDD:275380 1/22 (5%)
leucine-rich repeat 709..728 CDD:275380 4/18 (22%)
LRR_8 883..943 CDD:290566 14/59 (24%)
leucine-rich repeat 885..908 CDD:275380 4/22 (18%)
leucine-rich repeat 909..932 CDD:275380 4/22 (18%)
LRR_8 932..990 CDD:290566 16/57 (28%)
leucine-rich repeat 933..956 CDD:275380 8/22 (36%)
TIR 1114..1247 CDD:214587 44/143 (31%)
TLR2NP_001305716.1 PLN00113 <40..>206 CDD:331614 52/198 (26%)
leucine-rich repeat 54..77 CDD:275380 6/22 (27%)
LRR 1 54..77 6/22 (27%)
LRR_8 77..135 CDD:316378 25/87 (29%)
leucine-rich repeat 78..101 CDD:275380 10/47 (21%)
LRR 2 78..101 10/47 (21%)
leucine-rich repeat 102..125 CDD:275380 10/27 (37%)
LRR 3 102..125 10/27 (37%)
leucine-rich repeat 126..150 CDD:275380 10/23 (43%)
LRR 4 126..150 10/23 (43%)
leucine-rich repeat 151..175 CDD:275380 7/23 (30%)
LRR 5 151..175 7/23 (30%)
LRR 6 176..199 4/22 (18%)
leucine-rich repeat 176..196 CDD:275380 4/19 (21%)
LRR 7 200..223 5/22 (23%)
LRR 8 224..250 5/25 (20%)
LRR 9 251..278 5/28 (18%)
LRR 10 279..308 9/56 (16%)
LRR 11 309..337 7/28 (25%)
NEL <324..>558 CDD:330839 69/420 (16%)
LRR 12 338..361 2/27 (7%)
leucine-rich repeat 362..388 CDD:275380 8/25 (32%)
LRR 13 362..388 8/25 (32%)
leucine-rich repeat 389..414 CDD:275380 7/44 (16%)
LRR 14 389..414 7/44 (16%)
leucine-rich repeat 415..437 CDD:275380 10/61 (16%)
LRR 15 415..437 10/61 (16%)
leucine-rich repeat 438..478 CDD:275380 17/159 (11%)
LRR 16 438..457 8/110 (7%)
LRR 17 458..478 8/47 (17%)
leucine-rich repeat 479..500 CDD:275380 8/22 (36%)
LRR 18 479..500 8/22 (36%)
leucine-rich repeat 501..524 CDD:275380 7/22 (32%)
LRR 19 501..524 7/22 (32%)
LRRCT 533..586 CDD:214507 10/52 (19%)
TIR 640..784 CDD:214587 46/160 (29%)
ATG16L1-binding motif 761..778 5/16 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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