DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and TLR1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_003254.2	Gene:	TLR1 / 7096	HGNCID:	11847	Length:	786	Species:	Homo sapiens

Alignment Length:	966	Identity:	208/966 - (21%)
Similarity:	351/966 - (36%)	Gaps:	267/966 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDK 393
            :::.|.|.::.:|.:|              :...::||              :|.|.|:..|  .
Human    28 LVDRSKNGLIHVPKDL--------------SQKTTILN--------------ISQNYISELW--T 62

  Fly   394 NTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN 458
            :..:.|.:|.:|.:|||::..|:..:|.....|:.|:|.||:|..|:..   |..||..|.||.|
Human    63 SDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFN 124

  Fly   459 KLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK---TVPLALRNMRH 520
                    |.:.|.:..               .|.|.|.|:.|.|:...|:   .:|:|..|:..
Human   125 --------AFDALPICK---------------EFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISK 166

  Fly   521 LRTVDLGENMITVMEDSAFKGLG--NLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRI-AVV 582
            :..| |||   |..|....:||.  |...|.::  :..|...|...|:....:.||..:.| .|:
Human   167 VLLV-LGE---TYGEKEDPEGLQDFNTESLHIV--FPTNKEFHFILDVSVKTVANLELSNIKCVL 225

  Fly   583 EPGAFEMTSSIQA-----VRLDGNELNDIN---GLFSNMPSLLW------LNISDNRLE------ 627
            |........||.|     .:|....||:|.   ..|..:..|:|      .:||:.:|:
Human   226 EDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFR 290

  Fly   628 SFDYGHVPSTLQWLDLHKNRLSSLSNRFG--------LDSELKLQTLDVSFNQL-QRIGPSSIPN 683
            .|||.  .::|:.|.:|:    .:|:.||        :.|.:.::...||..:: ..:.||.|..
Human   291 DFDYS--GTSLKALSIHQ----VVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISP 349

  Fly   684 SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPF 748
            .:.|.|.| ||:|....:...|.|.|..:.|..||:..
Human   350 FLHLDFSN-NLLTDTVFENCGHLTELETLILQMNQLKE--------------------------- 386

  Fly   749 TCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCH 813
                    |.||..:|: |...:..|:      ::....:|     .|.|.
Human   387 --------LSKIAEMTT-QMKSLQQLD------ISQNSVSY-----DEKKG-------------- 417

  Fly   814 CCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHS 878
                   ||              :|:.:::..:
Human   418 -------DC--------------SWTKSLLSLN-------------------------------- 429

  Fly   879 FLGRKNLAVLYANNSNVAHIYNTTFSGL-KRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNK 942
                        .:||:  :.:|.|..| .|:.:|.|..|.|.|:. .:...||.|:||.:..|.
Human   430 ------------MSSNI--LTDTIFRCLPPRIKVLDLHSNKIKSIP-KQVVKLEALQELNVAFNS 479

  Fly   943 IASIAN-GSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLG 1006
            :..:.. |||.   .|.||.:|.|.:.|.......:...:..|...||.:.|.| .|..|...:.
Human   480 LTDLPGCGSFS---SLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTC-ELGEFVKNID 540

  Fly  1007 QSSEKIIDA--SRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAF 1069
            |.|.::::.  ....|.|..:      ..||  .|:|     .|.:|:...:.||:|...|.:..
Human   541 QVSSEVLEGWPDSYKCDYPES------YRGT--LLKD-----FHMSELSCNITLLIVTIVATMLV 592

  Fly  1070 FGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFV--DQLDKERPNDAYFAYSLQDEHFVNQILA 1132
            ..:.....|...:|. |.....|......:..|.:  ::|.:.....|:.:||..|..:|...|.
Human   593 LAVTVTSLCSYLDLP-WYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELL 656

  Fly  1133 QTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELV- 1196
            ..||.: |.::|||.|:......|.:.:|...|.:.:.:.|||.||:.:||..:|...|.|.|.
Human   657 PNLEKE-GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFH 720

  Fly  1197 KRRKRVVFILYGDLPQRDIDMD---MRHYLRTSTCIEWDDKK-----FWQKLRLAL 1244
            :....::.||...:||..|...   ::..:...|.:||..:|     ||..||.|:
Human   721 EGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	32/138 (23%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	8/56 (14%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380	4/20 (20%)
		LRR	350..729	CDD:227223	98/413 (24%)
		leucine-rich repeat	352..375	CDD:275380	2/22 (9%)
		leucine-rich repeat	376..401	CDD:275380	5/24 (21%)
		LRR_RI	<401..626	CDD:238064	63/244 (26%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..473	CDD:275380	7/22 (32%)
		leucine-rich repeat	474..497	CDD:275380	2/22 (9%)
		leucine-rich repeat	498..518	CDD:275380	6/22 (27%)
		leucine-rich repeat	521..544	CDD:275380	8/24 (33%)
		leucine-rich repeat	545..566	CDD:275380	3/20 (15%)
		leucine-rich repeat	569..592	CDD:275380	5/23 (22%)
		leucine-rich repeat	593..615	CDD:275380	7/29 (24%)
		leucine-rich repeat	616..637	CDD:275380	8/32 (25%)
		leucine-rich repeat	638..662	CDD:275380	7/31 (23%)
		leucine-rich repeat	663..684	CDD:275380	5/21 (24%)
		leucine-rich repeat	685..708	CDD:275380	7/22 (32%)
		leucine-rich repeat	709..728	CDD:275380	4/18 (22%)
		LRR_8	883..943	CDD:290566	17/60 (28%)
		leucine-rich repeat	885..908	CDD:275380	5/23 (22%)
		leucine-rich repeat	909..932	CDD:275380	6/22 (27%)
		LRR_8	932..990	CDD:290566	15/58 (26%)
		leucine-rich repeat	933..956	CDD:275380	7/23 (30%)
		TIR	1114..1247	CDD:214587	41/140 (29%)
TLR1	NP_003254.2	leucine-rich repeat	47..70	CDD:275378	7/38 (18%)
		LRR 1	54..77		6/24 (25%)
		LRR_8	69..124	CDD:316378	20/57 (35%)
		leucine-rich repeat	71..94	CDD:275378	7/22 (32%)
		LRR 2	78..101		6/22 (27%)
		leucine-rich repeat	95..115	CDD:275378	8/22 (36%)
		LRR 3	102..125		11/33 (33%)
		leucine-rich repeat	116..140	CDD:275378	9/46 (20%)
		LRR 4	126..150		7/38 (18%)
		leucine-rich repeat	141..152	CDD:275378	3/10 (30%)
		LRR 5	151..175		8/27 (30%)
		LRR 6	176..199		5/24 (21%)
		LRR 7	200..223		5/22 (23%)
		LRR 8	224..250		6/25 (24%)
		LRR 9	251..278		6/26 (23%)
		LRR 10	279..308		8/34 (24%)
		LRR 11	309..337		6/27 (22%)
		Interaction with bacterial lipopeptide	313..316		1/2 (50%)
		LRR 12	338..361		8/23 (35%)
		PLN00113	<352..>560	CDD:331614	61/341 (18%)
		leucine-rich repeat	352..373	CDD:275380	7/21 (33%)
		LRR 13	362..388		6/60 (10%)
		leucine-rich repeat	374..399	CDD:275380	9/60 (15%)
		LRR 14	389..414		6/36 (17%)
		leucine-rich repeat	400..424	CDD:275380	7/69 (10%)
		LRR 15	415..437		6/102 (6%)
		leucine-rich repeat	425..446	CDD:275380	5/66 (8%)
		LRR 16	438..457		7/18 (39%)
		leucine-rich repeat	447..469	CDD:275380	6/22 (27%)
		LRR 17	458..478		6/20 (30%)
		leucine-rich repeat	470..492	CDD:275380	7/24 (29%)
		LRR 18	479..500		7/23 (30%)
		leucine-rich repeat	494..515	CDD:275380	5/20 (25%)
		LRR 19	501..524		2/22 (9%)
		LRRCT	553..577	CDD:279765	8/36 (22%)
		TIR	636..779	CDD:214587	41/142 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820