DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Lingo3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001103079.1 Gene:Lingo3 / 690755 RGDID:1592209 Length:589 Species:Rattus norvegicus


Alignment Length:442 Identity:112/442 - (25%)
Similarity:180/442 - (40%) Gaps:99/442 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            ::|:.|   .:|...|.:|.||::.:|.   .|.:..||                          
  Rat    46 AVPEGI---PAETRMLELSRNRIRCLNP---GDLASLPT-------------------------- 78

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTE 343
            ||.||::||....:....|..|.|||||.:..|.:.:|.....:.|.:|.:|:||.||:|     
  Rat    79 LEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDSLTLLDLSENKLV----- 138

  Fly   344 LFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLS 408
                                :|....|.:|..||.|::..|.:  .:|.:..|.||:.|..|.|.
  Rat   139 --------------------ILLDFSFQDLRSLQRLEVGDNDL--VFISRRAFAGLLGLAELTLE 181

  Fly   409 HNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNN-LHTLLLSHNKLKYLDAYALNGLY 472
            ...||.|.||....|..|..|.|||..:..:....|..:.. ||                     
  Rat   182 RCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQKLPGLLH--------------------- 225

  Fly   473 VLSLLSLDNNALI-GVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNMRHLRTVDLGENMITVME 535
                |.:||..|: .|.|.:.|..: |..|::....:..|| .|||...||..::|..|.|:::.
  Rat   226 ----LEIDNWPLLEEVAPGSLRGLN-LTSLSITHTNITAVPAAALRQQAHLTCLNLSHNPISMVP 285

  Fly   536 DSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDG 600
            ..:|:.|..|..|.|.|..|..|....|..|..:::|||:.|.::.:|...|...::::.:|:||
  Rat   286 RGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDNLLSTLEENTFHSVNTLETLRVDG 350

  Fly   601 NELN-DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSL 651
            |.|. |..        |||: :...:..:|| |.:|:.....::..:.|.:|
  Rat   351 NPLACDCR--------LLWI-VQRRKTLNFD-GRLPACATPAEVRGDALHNL 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566 6/21 (29%)
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 11/63 (17%)
leucine-rich repeat 229..249 CDD:275380 6/19 (32%)
LRR_RI 278..468 CDD:238064 51/190 (27%)
leucine-rich repeat 279..302 CDD:275380 8/22 (36%)
LRR_8 301..386 CDD:290566 22/84 (26%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR 350..729 CDD:227223 78/306 (25%)
leucine-rich repeat 352..375 CDD:275380 3/22 (14%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 61/228 (27%)
leucine-rich repeat 402..425 CDD:275380 9/22 (41%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 2/22 (9%)
leucine-rich repeat 474..497 CDD:275380 7/23 (30%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 6/22 (27%)
leucine-rich repeat 545..566 CDD:275380 7/20 (35%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 6/22 (27%)
leucine-rich repeat 616..637 CDD:275380 7/20 (35%)
leucine-rich repeat 638..662 CDD:275380 2/14 (14%)
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
Lingo3NP_001103079.1 LRRNT 23..55 CDD:214470 2/11 (18%)
leucine-rich repeat 34..53 CDD:275380 2/9 (22%)
LRR <55..353 CDD:227223 98/379 (26%)
leucine-rich repeat 55..78 CDD:275380 6/25 (24%)
leucine-rich repeat 79..102 CDD:275380 8/22 (36%)
leucine-rich repeat 103..150 CDD:275380 17/71 (24%)
leucine-rich repeat 151..174 CDD:275380 8/24 (33%)
leucine-rich repeat 175..198 CDD:275380 9/22 (41%)
leucine-rich repeat 199..222 CDD:275380 6/22 (27%)
leucine-rich repeat 223..246 CDD:275380 9/47 (19%)
LRR_8 246..302 CDD:404697 17/56 (30%)
leucine-rich repeat 247..270 CDD:275380 7/22 (32%)
leucine-rich repeat 271..292 CDD:275380 5/20 (25%)
leucine-rich repeat 295..316 CDD:275380 7/20 (35%)
leucine-rich repeat 319..342 CDD:275380 6/22 (27%)
PCC 331..>405 CDD:188093 17/72 (24%)
Ig 407..489 CDD:416386
Ig strand A' 413..417 CDD:409353
Ig strand B 423..432 CDD:409353
Ig strand C 437..442 CDD:409353
Ig strand C' 445..447 CDD:409353
Ig strand D 456..459 CDD:409353
Ig strand E 462..469 CDD:409353
Ig strand F 475..483 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.