DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and SLIT3

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001258875.2 Gene:SLIT3 / 6586 HGNCID:11087 Length:1530 Species:Homo sapiens


Alignment Length:1704 Identity:340/1704 - (19%)
Similarity:558/1704 - (32%) Gaps:654/1704 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....:.|:.:....||:.||.|.|..:.:      ..||..||...::||||.|:.|.:.
Human    64 ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV------SVIERGAFQDLKQLERLRLNKNKLQ 122

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            .||:.:|.:..:|:.|::|||::|.:....||        |.|                     |
Human   123 VLPELLFQSTPKLTRLDLSENQIQGIPRKAFR--------GIT---------------------D 158

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKI------ 337
            ::.|.:.:|....:....|..||.|.:|::|||.||.|...:.:.:..::.|.|.||.:      
Human   159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL 223

  Fly   338 ------------------------------------------------------VALPT------ 342
                                                                  ::.|:      
Human   224 AWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSN 288

  Fly   343 -----------ELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS-------- 388
                       |:.|...:.|.|:.|:.|||..:....|:...:|:.:|:|.|||:.        
Human   289 NIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQG 353

  Fly   389 --------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENI 439
                          |.|.|..|.||:.|.||.|:.||:..|....|.||..|.:|:|..|:|:.|
Human   354 LKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTI 418

  Fly   440 AADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALIGVHPDAF 492
            :...|||:.::.||.|:.|      .||:|..|      ..:|....|...|.|..:..:....|
Human   419 SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKF 483

  Fly   493 RNCSALQD-------------------------LNLNGNQLKTVPLALRNMRHLRTVDLGENMIT 532
            | ||..:|                         ::.:..:|..:|..|  ..::..:.|.:|.::
Human   484 R-CSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHL--PEYVTDLRLNDNEVS 545

  Fly   533 VMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVR 597
            |:|.:..                       |:.||||:.:||:.|:|..|..|||:..:|:|.:.
Human   546 VLEATGI-----------------------FKKLPNLRKINLSNNKIKEVREGAFDGAASVQELM 587

  Fly   598 LDGNELNDING-LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSEL 661
            |.||:|..::| :|..:                      |.|:.|.|..|.:..:||.       
Human   588 LTGNQLETVHGRVFRGL----------------------SGLKTLMLRSNLIGCVSND------- 623

  Fly   662 KLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKS 726
                   :|..|         :|:.||.|.||.|||:.|..|....:|:.::|.:          
Human   624 -------TFAGL---------SSVRLLSLYDNRITTITPGAFTTLVSLSTINLLS---------- 662

  Fly   727 LRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQY----PRIMDLETIYCKLLNNRER 787
                               |||.|:|::.||.|  .:..|:.    ||..  :..:.|       
Human   663 -------------------NPFNCNCHLAWLGK--WLRKRRIVSGNPRCQ--KPFFLK------- 697

  Fly   788 AYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSE 852
             .||:.:...:.|.|...          |..:|.....||..|||..      .:|.||......
Human   698 -EIPIQDVAIQDFTCDGN----------EESSCQLSPRCPEQCTCME------TVVRCSNKGLRA 745

  Fly   853 MPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDN 917
            :||.:|.|.:|||::||:...:. ......::|.::..:|::::.:.|.|||.:..|..|.|..|
Human   746 LPRGMPKDVTELYLEGNHLTAVP-RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYN 809

  Fly   918 HIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGN----------------- 965
            .:..:..:.|:.|.:||.|.|..|.|:|:..|||..|..|..|.|..|                 
Human   810 RLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKA 874

  Fly   966 ------------------RLM------HFE---VWQLSANPYLVEISLADNQ------------- 990
                              ||:      .|:   :|.....|..:.|....|.             
Human   875 GYKEPGIARCSSPEPMADRLLLTTPTHRFQCKVLWFCCPGPVDINIVAKCNACLSSPCKNNGTCT 939

  Fly   991 ------WSCECGYLARFRNYLGQSSEKIIDASRVSCIYN----NATSVLRE--KNGTKC------ 1037
                  :.|.|.|     :|.|:.....|:    :||.|    ..|..|.:  |:|..|      
Human   940 QDPVELYRCACPY-----SYKGKDCTVPIN----TCIQNPCQHGGTCHLSDSHKDGFSCSCPLGF 995

  Fly  1038 ---------------------TLRDGVAHYM------HTNE-----IEGLLPLLLVATCAFVAFF 1070
                                 |..||:.:|:      :|.|     |:..:|             
Human   996 EGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVP------------- 1047

  Fly  1071 GLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTL 1135
                       ||.:..|...|:            .|||....:....||.:        |.:|.
Human  1048 -----------ELNLCQHEAKCI------------PLDKGFSCECVPGYSGK--------LCETD 1081

  Fly  1136 ENDIGYRLCLHYRDV--NINAYITD----------------ALIEAA-------ESAKQFVLV-- 1173
            .:|.....|.|....  .||.|...                .|::.:       ::..|.::|  
Human  1082 NDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQ 1146

  Fly  1174 ------------------LSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMR 1220
                              ::.||:        .|.:..||...:.|         ||.:|     
Human  1147 EPTCRCPPGFAGPRCEKLITVNFV--------GKDSYVELASAKVR---------PQANI----- 1189

  Fly  1221 HYLRTSTCIEWDDKKFWQKLRLALPLPNG----RGNNNK----------RVVSGCLSGRTPSVNM 1271
                              .|::|....||    :|:|:.          |:|...||  :|...:
Human  1190 ------------------SLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLS--SPPTTV 1234

  Fly  1272 YATSHEYQAGNGG--------VIPPPSARYADCGS-NNYATINECAAAG-------GGRGYKPIP 1320
            |:.    :..|.|        .:........|.|: .:...:.:..|.|       ||     ||
Human  1235 YSV----ETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGG-----IP 1290

  Fly  1321 TSASAAAAACKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPA 1385
            ||...:|.            :|..|..:.|.     |...|..:.|...|...|:|......:|.
Human  1291 TSTGLSAL------------RQGTDRPLGGF-----HGCIHEVRINNELQDFKALPPQSLGVSPG 1338

  Fly  1386 YDSVDYAKQQI-----RNNANCECVN--LGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKS 1443
            ..|....|..:     :::..|||..  .|.......::|..|...........  |.||.||  
Human  1339 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVAT--GTSYMCK-- 1399

  Fly  1444 CSCIGDDELLCSCGGGGGIGVNLLESGTQSSVTMSSSSNNSRQPELTHYESNLSLNDDEDE---- 1504
                      |:.|.||.:..|           .:.|:|.....:..|.:.::|   |:.|    
Human  1400 ----------CAEGYGGDLCDN-----------KNDSANACSAFKCHHGQCHIS---DQGEPYCL 1440

  Fly  1505 -------DHDQQKN 1511
                   :|.||:|
Human  1441 CQPGFSGEHCQQEN 1454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733 27/92 (29%)
leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
LRR_8 200..>246 CDD:404697 16/45 (36%)
leucine-rich repeat 202..278 CDD:275380 19/75 (25%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR 299..654 CDD:443914 106/491 (22%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 7/99 (7%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 12/46 (26%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 9/22 (41%)
leucine-rich repeat 450..473 CDD:275380 9/34 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 4/44 (9%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 7/22 (32%)
leucine-rich repeat 616..637 CDD:275380 0/20 (0%)
leucine-rich repeat 638..662 CDD:275380 6/23 (26%)
LRR_8 662..719 CDD:404697 15/56 (27%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 10/22 (45%)
leucine-rich repeat 709..728 CDD:275380 2/18 (11%)
LRR <863..>990 CDD:443914 38/170 (22%)
leucine-rich repeat 885..908 CDD:275380 6/22 (27%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
leucine-rich repeat 933..956 CDD:275380 11/22 (50%)
TIR 1114..1247 CDD:214587 24/177 (14%)
SLIT3NP_001258875.2 LRRNT 33..64 CDD:214470 340/1704 (20%)
LRR <62..>217 CDD:443914 49/187 (26%)
LRR 1 62..83 2/18 (11%)
leucine-rich repeat 64..86 CDD:275380 4/21 (19%)
LRR 2 86..107 8/26 (31%)
leucine-rich repeat 87..110 CDD:275380 8/28 (29%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 8/28 (29%)
leucine-rich repeat 135..158 CDD:275380 10/51 (20%)
LRR 5 158..179 4/20 (20%)
leucine-rich repeat 159..182 CDD:275380 4/22 (18%)
LRR 6 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
PCC 188..>250 CDD:188093 10/61 (16%)
leucine-rich repeat 207..308 CDD:275380 7/100 (7%)
LRRNT 280..311 CDD:214470 4/30 (13%)
LRR 7 308..329 7/20 (35%)
leucine-rich repeat 309..332 CDD:275380 7/22 (32%)
LRR <326..666 CDD:443914 101/439 (23%)
LRR 8 332..353 6/20 (30%)
leucine-rich repeat 333..356 CDD:275380 6/22 (27%)
LRR 9 356..377 4/20 (20%)
leucine-rich repeat 357..377 CDD:275380 4/19 (21%)
LRR 10 380..401 8/20 (40%)
leucine-rich repeat 381..404 CDD:275380 10/22 (45%)
LRR 11 404..425 7/20 (35%)
leucine-rich repeat 405..428 CDD:275380 9/22 (41%)
LRR 12 533..554 4/43 (9%)
leucine-rich repeat 534..558 CDD:275380 6/46 (13%)
LRR 13 558..579 10/20 (50%)
leucine-rich repeat 559..582 CDD:275380 9/22 (41%)
LRR 14 582..603 8/20 (40%)
leucine-rich repeat 583..606 CDD:275380 7/44 (16%)
LRR 588..>900 CDD:443914 92/414 (22%)
LRR 15 606..627 7/34 (21%)
leucine-rich repeat 607..630 CDD:275380 8/45 (18%)
LRR 16 630..651 11/20 (55%)
leucine-rich repeat 631..654 CDD:275380 10/22 (45%)
leucine-rich repeat 655..745 CDD:275380 28/146 (19%)
leucine-rich repeat 746..776 CDD:275380 9/30 (30%)
LRR 17 753..775 6/22 (27%)
LRR 18 776..797 5/20 (25%)
leucine-rich repeat 777..800 CDD:275380 6/22 (27%)
LRR 19 800..821 5/20 (25%)
leucine-rich repeat 801..824 CDD:275380 6/22 (27%)
LRR 20 824..845 10/20 (50%)
leucine-rich repeat 825..846 CDD:275380 10/20 (50%)
EGF_CA 963..1001 CDD:238011 9/41 (22%)
EGF_CA 1005..1038 CDD:238011 6/32 (19%)
EGF_CA 1042..1079 CDD:238011 12/80 (15%)
EGF_CA 1081..1117 CDD:238011 6/35 (17%)
EGF 1130..1160 CDD:394967 2/29 (7%)
Laminin_G_2 1195..1321 CDD:460494 29/153 (19%)
EGF 1379..1407 CDD:394967 9/41 (22%)
GHB_like <1473..1528 CDD:473907
Blue background indicates that the domain is not in the aligned region.

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