DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and SLIT1

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_003052.2 Gene:SLIT1 / 6585 HGNCID:11085 Length:1534 Species:Homo sapiens


Alignment Length:998 Identity:218/998 - (21%)
Similarity:345/998 - (34%) Gaps:340/998 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....:.|:.:....||:|||.|.|..:.|      ..:|..||...:.||||.|:.|.:.
Human    64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQI------GAVERGAFDDMKELERLRLNRNQLH 122

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            .||:.:|.....||.|::|||.:|.:....||        |:|                     |
Human   123 MLPELLFQNNQALSRLDLSENAIQAIPRKAFR--------GAT---------------------D 158

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK------- 336
            |:.|.:..|....:....|..||.|.||::|||.|:.|...:.:.:..|:...|.||.       
Human   159 LKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHL 223

  Fly   337 ----------------------------------------------------------------- 336
                                                                             
Human   224 AWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTC 288

  Fly   337 -----------IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS-- 388
                       :.|:|..|    .:.:.|:.|:.|.|..:.|..||...:|:.:|||.|||..  
Human   289 SNGIVDCRGKGLTAIPANL----PETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 349

  Fly   389 --------------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRH 433
                                |.:.:..|.||..|.||.|:.||:..:.|:.|.||..|.:|:|..
Human   350 PDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYD 414

  Fly   434 NQLENIAADTFAPMNNLHTLLLSHN------KLKYL------DAYALNGLYVLSLLSLDNNALIG 486
            |:::::|..||..:..:.||.|:.|      .||:|      :....:|....|...|.|..:..
Human   415 NKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQ 479

  Fly   487 VHPDAFRNCSA--------LQDLNLNG---------------------NQLKTVPLALRNMRHLR 522
            :....|| |||        .:|..||.                     :.||...:..|..:...
Human   480 IKSKKFR-CSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTA 543

  Fly   523 TVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAF 587
            .:.|..|.|:::|.:..                       |:.|.:|:.:||:.|:::.:|.|||
Human   544 ELRLNNNEISILEATGM-----------------------FKKLTHLKKINLSNNKVSEIEDGAF 585

  Fly   588 EMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSL 651
            |..:|:..:.|..|:|..| :|:|..:..|..|.:.:||:..              :|.:..:.|
Human   586 EGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISC--------------IHNDSFTGL 636

  Fly   652 SNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYA 716
            .|                               :.||.|.||.||||.|..|....:|:.::|.|
Human   637 RN-------------------------------VRLLSLYDNQITTVSPGAFDTLQSLSTLNLLA 670

  Fly   717 NQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI----DWLQKINHITSRQYPRIMDLETI 777
                                         |||.|:|.:    .||:|...:|..  ||..:.:.:
Human   671 -----------------------------NPFNCNCQLAWLGGWLRKRKIVTGN--PRCQNPDFL 704

  Fly   778 YCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNI 842
                      ..|||.:.....|.|....         |...|.....||..|.|.      ..:
Human   705 ----------RQIPLQDVAFPDFRCEEGQ---------EEGGCLPRPQCPQECACL------DTV 744

  Fly   843 VECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLK 907
            |.||......:|:.:|.:.:|||:|||.|..:.|.                         .|..|
Human   745 VRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQ-------------------------LSTFK 784

  Fly   908 RLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEV 972
            .|.::.|.:|.|.||..:.|.|:..|..|.|..|.:..|...:||.||.|.:|.|.||.:...:.
Human   785 YLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849

  Fly   973 WQLSANPYLVEISLADNQWSCEC 995
            ...:....|..:::..|...|:|
Human   850 GIFADVTSLSHLAIGANPLYCDC 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
LRR_8 171..236 CDD:290566 24/64 (38%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
leucine-rich repeat 202..278 CDD:275380 20/75 (27%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 64/306 (21%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
LRR_8 301..386 CDD:290566 28/167 (17%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 7/105 (7%)
LRR 350..729 CDD:227223 100/442 (23%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 11/46 (24%)
LRR_RI <401..626 CDD:238064 64/266 (24%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 8/34 (24%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 6/40 (15%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 6/22 (27%)
leucine-rich repeat 616..637 CDD:275380 4/20 (20%)
leucine-rich repeat 638..662 CDD:275380 3/23 (13%)
leucine-rich repeat 663..684 CDD:275380 0/20 (0%)
leucine-rich repeat 685..708 CDD:275380 11/22 (50%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 14/59 (24%)
leucine-rich repeat 885..908 CDD:275380 1/22 (5%)
leucine-rich repeat 909..932 CDD:275380 8/22 (36%)
LRR_8 932..990 CDD:290566 15/57 (26%)
leucine-rich repeat 933..956 CDD:275380 8/22 (36%)
TIR 1114..1247 CDD:214587
SLIT1NP_003052.2 LRRNT 33..64 CDD:214470 218/998 (22%)
leucine-rich repeat 43..62 CDD:275380
LRR_8 61..121 CDD:290566 19/62 (31%)
LRR 1 62..83 2/18 (11%)
leucine-rich repeat 63..86 CDD:275380 4/21 (19%)
LRR_4 64..101 CDD:289563 10/42 (24%)
LRR 2 86..107 9/26 (35%)
LRR_RI <87..220 CDD:238064 47/167 (28%)
leucine-rich repeat 87..110 CDD:275380 8/28 (29%)
LRR_8 109..169 CDD:290566 24/88 (27%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 9/28 (32%)
leucine-rich repeat 135..158 CDD:275380 11/51 (22%)
LRR 5 158..179 5/20 (25%)
LRR_8 159..217 CDD:290566 18/57 (32%)
leucine-rich repeat 159..182 CDD:275380 5/22 (23%)
LRR 6 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
leucine-rich repeat 207..334 CDD:275380 14/130 (11%)
TPKR_C2 219..264 CDD:301599 0/44 (0%)
LRRNT 282..313 CDD:214470 3/34 (9%)
LRR 7 310..331 6/20 (30%)
LRR_8 312..369 CDD:290566 14/56 (25%)
LRR_4 334..373 CDD:289563 8/38 (21%)
LRR 8 334..355 7/20 (35%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
LRR 9 358..379 2/20 (10%)
leucine-rich repeat 359..379 CDD:275380 2/19 (11%)
LRR 10 382..403 8/20 (40%)
leucine-rich repeat 383..406 CDD:275380 10/22 (45%)
LRR_8 389..441 CDD:290566 17/51 (33%)
LRR 11 406..427 7/20 (35%)
leucine-rich repeat 407..428 CDD:275380 7/20 (35%)
leucine-rich repeat 431..528 CDD:275380 19/97 (20%)
TPKR_C2 439..>469 CDD:301599 5/29 (17%)
LRRNT 513..542 CDD:214470 3/28 (11%)
leucine-rich repeat 529..566 CDD:275380 9/59 (15%)
LRR 12 541..562 4/43 (9%)
LRR_RI <544..627 CDD:238064 26/105 (25%)
LRR_8 544..601 CDD:290566 18/79 (23%)
LRR 13 566..587 8/20 (40%)
leucine-rich repeat 567..590 CDD:275380 9/22 (41%)
LRR_8 590..649 CDD:290566 19/103 (18%)
LRR 14 590..611 7/20 (35%)
leucine-rich repeat 591..614 CDD:275380 6/22 (27%)
LRR 15 614..635 5/34 (15%)
LRR_4 615..654 CDD:289563 16/83 (19%)
leucine-rich repeat 615..638 CDD:275380 6/36 (17%)
LRR 16 638..659 12/51 (24%)
leucine-rich repeat 639..660 CDD:275380 11/20 (55%)
leucine-rich repeat 663..762 CDD:275380 30/154 (19%)
LRRCT 671..719 CDD:214507 15/59 (25%)
LRRNT 733..765 CDD:214470 9/37 (24%)
LRR_8 761..820 CDD:290566 22/83 (27%)
LRR 17 762..783 9/45 (20%)
leucine-rich repeat 763..785 CDD:275380 9/46 (20%)
LRR 18 785..806 7/20 (35%)
LRR_4 786..827 CDD:289563 13/40 (33%)
leucine-rich repeat 786..809 CDD:275380 8/22 (36%)
LRR 19 809..830 6/20 (30%)
leucine-rich repeat 810..830 CDD:275380 6/19 (32%)
LRR 20 833..854 5/20 (25%)
leucine-rich repeat 834..857 CDD:275380 5/22 (23%)
LRRCT 866..915 CDD:214507 3/7 (43%)
EGF_CA 927..962 CDD:238011
EGF_CA 966..1002 CDD:238011
EGF_CA 1005..1041 CDD:238011
EGF_CA 1044..1080 CDD:238011
EGF_CA 1085..1119 CDD:238011
EGF_CA <1136..1163 CDD:238011
LamG 1189..1322 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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