DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and lgi3

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001034768.1	Gene:	lgi3 / 654830	ZFINID:	ZDB-GENE-060217-4	Length:	551	Species:	Danio rerio

Alignment Length:	508	Identity:	107/508 - (21%)
Similarity:	179/508 - (35%)	Gaps:	113/508 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   792 LIEAEPKHFLCTYKTHCFAVCHC--CEFDACDCEMT-----CPTNCTCFHDQTW--STNIVECSG 847
            ::||.|:..| .:....::||..  |.|........     ||..|:|..|..:  .|.::
Zfish     1 MVEARPRRTL-RWPDWRWSVCVLLFCMFGTAPGRKAPKSPRCPATCSCTKDSAFCVDTKVI---- 60

  Fly   848 AAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLIL 912
                  |:..|.....|.:....|.|:...:|.....|..|..|::..:.|.:..||||..|..|
Zfish    61 ------PKSFPTGIISLTMVNAAFTEIPEGAFSHMHLLQFLLLNSNTFSVISDDAFSGLGHLQYL 119

  Fly   913 HLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGN------RLMHFE 971
            .:|:|.|.:|..:.|..|::|..|.|.:|.:..:....|:.|..|..|.|.||      ::....
Zfish   120 FIENNDIQALSKHTFRGLKSLTHLSLSNNNLQVLPRELFKHLDILTDLDLRGNSFRCDCKIKWLV 184

  Fly   972 VWQLSANPYLVEI--------------SLADNQWSCECGYLARFRNYLGQS----SEKIIDASRV 1018
            .|....|..:..|              .|....::|.....|.:..|..||    |.:..|...|
Zfish   185 DWMEKTNTSVPPIYCASPFEFQGRRIHELTPRDFNCISADFAVYETYSFQSLSVESYEFQDDQYV 249

  Fly  1019 SCIYNNATSVLREKNGTKCT--LRDGV-----AHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGL 1076
                     |..:.|...||  :.|.|     .||..|:........:::....::....|..|.
Zfish   250 ---------VFAQPNTGICTVFIWDHVNMLFKTHYNITSRSAVYCKPVVINNTLYMVVAQLFGGS 305

  Fly  1077 FCYRHE------LKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTL 1135
            ..|:.|      :||....|..:     :.|.|::....|  .|.|||. :......:..|.:..
Zfish   306 HIYKWEDGPLRFVKIQDIDTTRV-----RKPNFIETFQIE--GDWYFAV-VDSSKAGSTSLYRWN 362

  Fly  1136 ENDIGYRLCLH--YRDVNINAYITDA---LIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALH-- 1193
            .|.......||  :||.:|:....|.   ||.::.|....|.         :|:|.:.:...|
Zfish   363 SNGFYSHQSLHPWHRDTHIDFLEVDGKPRLILSSASQPPVVY---------QWNRSQRQFVFHSQ 418

  Fly  1194 -------ELVKR---RKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKF 1236
                   ::||.   ||    :||         :.:..::..|..:.||:::|
Zfish   419 ITDSGDVQMVKHFWVRK----VLY---------LCLTRFIGDSKILRWDNQRF 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	20/59 (34%)
		leucine-rich repeat	885..908	CDD:275380	8/22 (36%)
		leucine-rich repeat	909..932	CDD:275380	8/22 (36%)
		LRR_8	932..990	CDD:290566	15/77 (19%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	29/140 (21%)
lgi3	NP_001034768.1	LRR_8	92..150	CDD:290566	20/57 (35%)
		leucine-rich repeat	92..115	CDD:275378	8/22 (36%)
		LRR_4	115..>150	CDD:289563	12/34 (35%)
		leucine-rich repeat	116..139	CDD:275378	8/22 (36%)
		LRR	137..160	CDD:197688	6/22 (27%)
		leucine-rich repeat	140..163	CDD:275378	6/22 (27%)
		leucine-rich repeat	164..176	CDD:275378	5/11 (45%)
		LRRCT	172..220	CDD:214507	5/47 (11%)
		EPTP	224..265	CDD:281697	11/49 (22%)
		EPTP	271..311	CDD:281697	6/39 (15%)
		EPTP	316..362	CDD:281697	11/53 (21%)
		EPTP	365..407	CDD:281697	10/50 (20%)
		EPTP	412..454	CDD:281697	8/54 (15%)
		EPTP	457..498	CDD:281697	1/2 (50%)
		EPTP	503..543	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000