DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and lgi1b

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001122241.1	Gene:	lgi1b / 654829	ZFINID:	ZDB-GENE-060217-1	Length:	543	Species:	Danio rerio

Alignment Length:	468	Identity:	95/468 - (20%)
Similarity:	173/468 - (36%)	Gaps:	107/468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||:.|||..|.....|:        ..:|...|.|...|....:.|.|:||.|||...:|.:|..
Zfish    34 CPSGCTCTKDNALCENV--------RSVPHSFPPDVISLSFVKSGFSEIAGGSFLHTPSLQLLLF 90

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            ..::...|....|.||..|..|.:|:|.|.|:..:.|..|::|..|.|..|.:.::....|:.:.
Zfish    91 TANSFDLIDEDAFQGLPHLEYLFIENNKIESISPHAFRGLKSLIHLSLAYNNLETLPRDIFKGMD 155

  Fly   956 KLEVLRLDGN------RLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIID 1014
            .|..:.|.||      :|.....|..|.|..:.::            |.:....|.|:....::.
Zfish   156 ALTKVDLRGNLFSCDCKLKWLVEWMFSTNATVDQL------------YCSGPSPYQGKKINDLMP 208

  Fly  1015 ASRVSCI---------------------YNNATSVLREKNGT-KCTLRDGVAHYMHTNEIEGLLP 1057
            .| ..||                     |.|...|:..:..| :|...:.....|...:.|.:|.
Zfish   209 QS-FDCITAEFALKKTLAFESISVEAFSYGNDQYVVYAQPFTGRCNFMEWDHVNMEFRDHEIILS 272

  Fly  1058 L-------LLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDA 1115
            .       :::....|:....|..|...|:.:     .|.|..:..     :.:|.|...:|||.
Zfish   273 TSTVVCKPMVIDDHLFIVVAQLFGGSHIYKRD-----SSANKFIKI-----QDIDILKIRKPNDI 327

  Fly  1116 YFAYSLQDEHFVNQILAQTLE---------NDIGYRLCLHYRDVNINAYITDALIEAAESAKQFV 1171
            . .:.:..|.:.  ::|.:.:         |..|:     |...:::.:..|..:|..|.|.:..
Zfish   328 E-TFRVDGEFYF--VIADSSKAGSTTVYKWNGNGF-----YSHQSLHPWYRDTDVEYLEIAGKPH 384

  Fly  1172 LVLSKN----FLYNEWSR----FEYKSALHEL-----VKRRKRVVFILYGDLPQRDIDMDMRHYL 1223
            ::||.:    .:| :|||    |:.::.:.::     ||.     |.:.|:|     .:.:..::
Zfish   385 IILSSSSQWPVVY-QWSRSQKQFDRRTDIPDMEDVYAVKH-----FKVKGEL-----FICLTRFI 438

  Fly  1224 RTSTCIEWDDKKF 1236
            ..|..::||...|
Zfish   439 GDSKVMKWDGAMF 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	18/59 (31%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	8/22 (36%)
		LRR_8	932..990	CDD:290566	13/63 (21%)
		leucine-rich repeat	933..956	CDD:275380	5/22 (23%)
		TIR	1114..1247	CDD:214587	26/145 (18%)
lgi1b	NP_001122241.1	LRR_8	83..143	CDD:290566	18/59 (31%)
		LRR_4	83..124	CDD:289563	12/40 (30%)
		leucine-rich repeat	85..108	CDD:275378	6/22 (27%)
		LRR_4	107..147	CDD:289563	12/39 (31%)
		leucine-rich repeat	109..132	CDD:275378	8/22 (36%)
		leucine-rich repeat	133..156	CDD:275378	5/22 (23%)
		leucine-rich repeat	157..169	CDD:275378	4/11 (36%)
		LRRCT	165..213	CDD:214507	9/60 (15%)
		EPTP	217..258	CDD:281697	5/40 (13%)
		EPTP	263..304	CDD:281697	6/40 (15%)
		EPTP	309..355	CDD:281697	7/53 (13%)
		EPTP	358..400	CDD:281697	9/47 (19%)
		EPTP	405..447	CDD:281697	7/51 (14%)
		EPTP	450..491	CDD:281697	1/2 (50%)
		EPTP	496..536	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000