DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and lgi2a

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001034730.1	Gene:	lgi2a / 654827	ZFINID:	ZDB-GENE-060217-2	Length:	536	Species:	Danio rerio

Alignment Length:	496	Identity:	102/496 - (20%)
Similarity:	168/496 - (33%)	Gaps:	163/496 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||::|:|      |...:.|.|::|  :||.:|.|.|.|.|....|.|:....|....:|.:|..
Zfish    27 CPSSCSC------SKESIICVGSSY--VPRYIPNDVSSLSIVNGTFSEVKEAMFSHMPSLQLLLL 83

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            |::.:..:.:..||||..|..|.:|:|.|.:.....|..|.:|..|.|.:|.|.::....|
Zfish    84 NSNALTTVRDDAFSGLPHLEYLFIENNKIETTSKYSFRGLRDLTHLSLANNNIKALPRELF---- 144

  Fly   956 KLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSC 1020
                :.||.                |:|:.|..|.:.|:|  .|::.....:|:...:  |.|.|
Zfish   145 ----IDLDS----------------LIELDLRGNVFECDC--RAKWLMMWLKSTNATV--SDVLC 185

  Fly  1021 I---------YNNATSVLREKNGTKCTLRD------------GVAHYMHTNEIEGLLPLLLVATC 1064
            .         .|:..|:..|     |...|            .|..:.|.|::...:......:|
Zfish   186 AGPEEMKGKRLNDMASLHNE-----CISTDFIPLHSVPTESLSVDTFSHKNDVYVAIAAPNAESC 245

  Fly  1065 AFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYS--------L 1121
            ..:.                 |.|..   |||              |..|.....|        :
Zfish   246 MVLQ-----------------WDHIE---MNF--------------RTYDNITGQSIVGCKSVII 276

  Fly  1122 QDEHFVNQILAQTLENDIGYRL------CLHYRDVNINAYITDALIEAAESAKQFVLV------- 1173
            |:|.||  |:||.......|:.      ...::|:.::.......|||.:....:..:
Zfish   277 QNEVFV--IVAQLFGGSHIYKFDEDQSKFSKFQDIEVSKISKPNDIEAFQIGNDWFFIIADSSKA 339

  Fly  1174 -LSKNFLYNEWSRFEYKSALHE-------------------LVKR----------RKRVVFILYG 1208
             ||..:.:|:...:.|:| |||                   |..|          |....|.|.|
Zfish   340 GLSTLYKWNDKGFYSYQS-LHEWFRDTDAEFVNLDGKAHLILASRSQVPVIYQWSRSTQKFTLQG 403

  Fly  1209 DLP-------------QRDIDMDMRHYLRTSTCIEWDDKKF 1236
            ::|             :.|:.:.|..|:..|..:.|..|:|
Zfish   404 EIPNMEDVVAVKAFWIKEDLYLAMTRYIGDSKVLHWTAKEF 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	18/59 (31%)
		leucine-rich repeat	885..908	CDD:275380	7/22 (32%)
		leucine-rich repeat	909..932	CDD:275380	7/22 (32%)
		LRR_8	932..990	CDD:290566	11/57 (19%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	36/187 (19%)
lgi2a	NP_001034730.1	LRR_8	54..112	CDD:290566	17/57 (30%)
		LRR_8	100..158	CDD:290566	18/81 (22%)
		LRR_4	100..140	CDD:289563	12/39 (31%)
		leucine-rich repeat	102..125	CDD:275378	7/22 (32%)
		LRR_4	126..>158	CDD:289563	11/55 (20%)
		leucine-rich repeat	126..149	CDD:275378	7/30 (23%)
		leucine-rich repeat	150..162	CDD:275378	4/11 (36%)
		LRRCT	158..198	CDD:214507	8/43 (19%)
		EPTP	210..251	CDD:281697	5/57 (9%)
		EPTP	257..297	CDD:281697	12/55 (22%)
		EPTP	302..348	CDD:281697	6/45 (13%)
		EPTP	351..393	CDD:281697	7/42 (17%)
		EPTP	398..439	CDD:281697	8/40 (20%)
		EPTP	443..484	CDD:281697	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000