Protein Alignment Toll-6 and LRTM2

DIOPT Version :9

• Sequence 1: NP_001246765.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: XP_016875337.1
• Gene: LRTM2 / 654429
• HGNCID: 32443
• Length: 427
• Species: Homo sapiens
• Alignment Length: 246
• Identity: 68/246 - (27%)
• Similarity: 106/246 - (43%)
• Gaps: 47/246 - (19%)

  Fly   274 SCSLDLEYLDV--SHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK 336
            ||..|...|:|  |......:|.:.....|.|.:|   ||.:|.:...|.:.|.:||.|:||:|.
Human    99 SCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLL---NNKLSALPSWAFANLSSLQRLDLSNNF 160

  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIR 401
            :..||..:|.:... :.|:.|:||||..|:..|..:...|:.||||:
Human   161 LDRLPRSIFGDLTN-LTELQLRNNSIRTLDRDLLRHSPLLRHLDLSI------------------ 206

  Fly   402 LVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLK----- 461
                    |.|.:|.|.:|..|..|:.|:||.|:|:|:...||.|:.||..|.:..|..:
Human   207 --------NGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNL 263

  Fly   462 -----YLDAYALNGLYVLSLLSLDNNALIG-----VHPDAFRNCSALQDLN 502
                 :::.::..|..:..|.......|.|     |..:.|..||.|:|.|
Human   264 REFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQLEDEN 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	2/3 (67%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	55/201 (27%)
		leucine-rich repeat	279..302	CDD:275380	4/24 (17%)
		LRR_8	301..386	CDD:290566	30/84 (36%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	44/168 (26%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..401	CDD:275380	5/24 (21%)
		LRR_RI	<401..626	CDD:238064	31/117 (26%)
		leucine-rich repeat	402..425	CDD:275380	6/22 (27%)
		leucine-rich repeat	426..449	CDD:275380	10/22 (45%)
		leucine-rich repeat	450..473	CDD:275380	4/32 (13%)
		leucine-rich repeat	474..497	CDD:275380	6/27 (22%)
		leucine-rich repeat	498..518	CDD:275380	3/5 (60%)
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
LRTM2	XP_016875337.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010