DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and LGR6

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001017403.1 Gene:LGR6 / 59352 HGNCID:19719 Length:967 Species:Homo sapiens


Alignment Length:587 Identity:143/587 - (24%)
Similarity:234/587 - (39%) Gaps:144/587 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   250 EPTNGSTESTSTTESAKKSSSSSTSCSL--------DLE----YLDVSHNDFVVLPANGFGTLRR 302
            :|..|.|...:.....:.....|..||.        ||:    |||:|.|:...|....|..||.
Human    27 QPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRF 91

  Fly   303 LRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNP 367
            |..|.::.|.:|.|..:|.|||.:|:||.|.:|::..:|.|...|... :|.:.|..|.||::..
Human    92 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPS-LQSLRLDANLISLVPE 155

  Fly   368 QLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLR 432
            :.|..|..|:.|.|..|.:|.  |.......|..|..:.|:.|:::.:....|.:|.:|.:|:|.
Human   156 RSFEGLSSLRHLWLDDNALTE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLH 218

  Fly   433 HNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSA 497
            :|:::::...:|..::||.||.|::|||:..                         |.|.|....
Human   219 NNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-------------------------PVAIRTLGR 258

  Fly   498 LQDLNLNGNQLKTVP-LALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMH 561
            ||:|..:.|.:|.:| .|......|:|:...:|.|..:..|||:.|..|:.|.|.|    .:.:.
Human   259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQ 319

  Fly   562 TFRDL---PNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISD 623
            .|.||   .:|:||.|.|..|.::.                       :|:...:|.|..|.:|.
Human   320 EFPDLKGTTSLEILTLTRAGIRLLP-----------------------SGMCQQLPRLRVLELSH 361

  Fly   624 NRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELL 688
            |::|.....|....|:.:.|..||:..:    |.|          :|:||         :|::.|
Human   362 NQIEELPSLHRCQKLEEIGLQHNRIWEI----GAD----------TFSQL---------SSLQAL 403

  Fly   689 FLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCN 753
            .|:.|.|.::.|:.|....:|.::||..||:|||.:..|        ..|....:.||       
Human   404 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL--------GGLMHLKLKGN------- 453

  Fly   754 IDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFD 818
               |......:...:|::..||..|         ||                       .||.:.
Human   454 ---LALSQAFSKDSFPKLRILEVPY---------AY-----------------------QCCPYG 483

  Fly   819 AC 820
            .|
Human   484 MC 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 6/35 (17%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 60/193 (31%)
leucine-rich repeat 279..302 CDD:275380 9/26 (35%)
LRR_8 301..386 CDD:290566 29/84 (35%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
LRR 350..729 CDD:227223 96/382 (25%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
LRR_RI <401..626 CDD:238064 55/228 (24%)
leucine-rich repeat 402..425 CDD:275380 5/22 (23%)
leucine-rich repeat 426..449 CDD:275380 5/22 (23%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 3/22 (14%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 8/22 (36%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 1/21 (5%)
leucine-rich repeat 616..637 CDD:275380 6/20 (30%)
leucine-rich repeat 638..662 CDD:275380 6/23 (26%)
leucine-rich repeat 663..684 CDD:275380 3/20 (15%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 8/18 (44%)
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
LGR6NP_001017403.1 LRRNT 34..68 CDD:214470 5/33 (15%)
LRR_RI <57..199 CDD:238064 45/144 (31%)
leucine-rich repeat 70..91 CDD:275380 8/20 (40%)
LRR 1 91..112 6/20 (30%)
LRR_8 92..150 CDD:290566 20/58 (34%)
leucine-rich repeat 92..115 CDD:275380 9/22 (41%)
LRR 2 115..136 7/20 (35%)
leucine-rich repeat 116..139 CDD:275380 8/22 (36%)
LRR_RI 131..392 CDD:238064 78/319 (24%)
LRR 3 139..160 6/21 (29%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
LRR 4 163..186 6/24 (25%)
leucine-rich repeat 164..187 CDD:275380 7/24 (29%)
LRR_8 186..246 CDD:290566 16/59 (27%)
LRR 5 187..208 4/20 (20%)
leucine-rich repeat 188..211 CDD:275380 5/22 (23%)
LRR 6 211..232 5/20 (25%)
leucine-rich repeat 212..235 CDD:275380 5/22 (23%)
LRR 7 235..256 11/45 (24%)
leucine-rich repeat 236..258 CDD:275380 10/46 (22%)
LRR_8 258..314 CDD:290566 18/55 (33%)
LRR 8 258..279 7/20 (35%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
LRR 9 282..303 7/20 (35%)
leucine-rich repeat 283..304 CDD:275380 7/20 (35%)
LRR 10 306..328 7/25 (28%)
LRR 11 329..350 7/43 (16%)
leucine-rich repeat 330..344 CDD:275378 6/13 (46%)
LRR 12 353..374 6/20 (30%)
leucine-rich repeat 354..399 CDD:275380 15/67 (22%)
LRR_8 375..434 CDD:290566 20/81 (25%)
LRR 13 375..396 7/34 (21%)
leucine-rich repeat 376..390 CDD:275378 4/17 (24%)
LRR 14 399..420 7/20 (35%)
leucine-rich repeat 400..423 CDD:275380 6/22 (27%)
LRR 15 423..443 9/27 (33%)
leucine-rich repeat 424..444 CDD:275380 9/27 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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