DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and LRFN1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_065913.1	Gene:	LRFN1 / 57622	HGNCID:	29290	Length:	771	Species:	Homo sapiens

Alignment Length:	264	Identity:	71/264 - (26%)
Similarity:	111/264 - (42%)	Gaps:	46/264 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 LRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDING---- 608
            |||..|::..:....|.::.:|..|.|:||.|..|..|||....:::|:.||.|.|.::.|
Human    70 LRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLR 134

  Fly   609 LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQL 673
            ...|:..|:..|....|:||..:....||                         ::.||:|:|.|
Human   135 GLGNLRHLILGNNQIRRVESAAFDAFLST-------------------------VEDLDLSYNNL 174

  Fly   674 QRIGPSSIPNSIEL--LFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTL--DIKSLRILPVWE 734
            :.:...::...:.|  |.|:.|||..:...||:....|.|:|:.:|::..|  |...||......
Human   175 EALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGP 239

  Fly   735 HRALP-EFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPK 798
            ....| ....||||..|:|.:.||:::.        |..||||  |....:....|...|..|
Human   240 KPPTPLTVSFGGNPLHCNCELLWLRRLT--------REDDLET--CATPEHLTDRYFWSIPEE-- 292

  Fly   799 HFLC 802
            .|||
Human   293 EFLC 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223	49/188 (26%)
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064	24/81 (30%)
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380	5/17 (29%)
		leucine-rich repeat	569..592	CDD:275380	10/22 (45%)
		leucine-rich repeat	593..615	CDD:275380	7/25 (28%)
		leucine-rich repeat	616..637	CDD:275380	5/20 (25%)
		leucine-rich repeat	638..662	CDD:275380	0/23 (0%)
		leucine-rich repeat	663..684	CDD:275380	5/20 (25%)
		leucine-rich repeat	685..708	CDD:275380	8/24 (33%)
		leucine-rich repeat	709..728	CDD:275380	6/20 (30%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
LRFN1	NP_065913.1	LRR_RI	<65..174	CDD:238064	33/128 (26%)
		LRR_8	65..125	CDD:290566	19/54 (35%)
		LRR 1	66..87		5/16 (31%)
		leucine-rich repeat	67..90	CDD:275380	5/19 (26%)
		LRR 2	90..111		10/20 (50%)
		leucine-rich repeat	91..114	CDD:275380	10/22 (45%)
		LRR_8	113..174	CDD:290566	18/85 (21%)
		LRR 3	114..135		6/20 (30%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..159		6/20 (30%)
		leucine-rich repeat	139..163	CDD:275380	5/23 (22%)
		LRR_8	162..222	CDD:290566	19/84 (23%)
		LRR 5	163..184		6/45 (13%)
		leucine-rich repeat	164..187	CDD:275380	5/22 (23%)
		LRR_4	165..203	CDD:289563	11/37 (30%)
		LRR 6	187..208		8/20 (40%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		LRR 7	211..232		6/20 (30%)
		leucine-rich repeat	212..230	CDD:275380	6/17 (35%)
		LRRCT	252..>284	CDD:214507	12/41 (29%)
		IG_like	310..385	CDD:214653
		Ig	314..387	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422
		fn3	426..500	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..743
		PDZ-binding	768..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910