DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and LOC572462

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_005167813.2	Gene:	LOC572462 / 572462	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1224	Identity:	248/1224 - (20%)
Similarity:	424/1224 - (34%)	Gaps:	401/1224 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 ALHILCNDEIMAKS-------------RLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLR 173
            ||.|||.......|             .|...||.|    .:.||..|      ..|.|..|.||
Zfish    14 ALFILCPKTCYVCSWLAEKCHFFSDVEGLNIASFYH----GKTSIAEC------LSVTDIKEDLR 68

  Fly   174 NLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQD 238
            .|.....|:                   |.::||..:.:  |..|.|.....|..|.::
Zfish    69 GLPTNLLNL-------------------LVQMDLHFHGV--LAPNSFSRFGSLENLKIA------ 106

  Fly   239 VNELG-FRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEY--------LDVSHNDFVVLPA 294
                | |.:...|..||.|..||.|.:|   ..|...|.:.|::        |.:||:|..:|..
Zfish   107 ----GCFSEIPPEAFNGLTNVTSLTITA---LDSKNCCEVALDFSHLPSLTSLFISHHDLSLLAL 164

  Fly   295 NGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSS----NKIVALPTELFAEQAKIIQEV 355
            |.|..:..|:.|.:::..:..::| .|..|.|:::|.|.|    |                   :
Zfish   165 NVFEKIPHLQWLYLDSVCLKDLSD-VLCRLANVKLLKLFSLDDWN-------------------I 209

  Fly   356 YLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIF 420
            .||..:.||.|....|....::.:||.:.::..  ||:..|....:|.||:.|.:....||
Zfish   210 RLQYQNCSVFNTTDISTEFSIETVDLLLGKLEH--IDEGAFKPFGKLSLLHFSVSNTDFLE---- 268

  Fly   421 SDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN--KLKYLDAYALNGLYVLSLLSLDNNA 483
             ||..:.:     :|:..|:|  ...:.|:..|.::..  .:|.:|.|     |....|||.:..
Zfish   269 -DLSLIGV-----HQISKISA--IVDVLNVDDLCVAAKLYSVKSVDVY-----YKTINLSLTSKG 320

  Fly   484 LIG--------VHPDAFRNCSALQDLN------------------LNGNQLKT------------ 510
            .:|        :..|..|....|.|:|                  |..|..::
Zfish   321 SVGCKEIGYITLENDISREIVNLLDVNSVFQIFSNLTSAAIYRHVLRSNDFQSLCASYPQNVKQL 385

  Fly   511 VPLALRNMR-------------HLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHT 562
            :.:.|:.:|             :|:|:.|..:.|:|.||.||.||..|..|.|..|.:.:|..||
Zfish   386 INMVLQTIRIDKIVSHQFMCFVNLKTLKLVMSKISVFEDFAFIGLNKLKELNLHRNKISSIHRHT 450

  Fly   563 FRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLE 627
            |..|..|::|:|..|.|..:||.:|                    |.|:|:.|.|..::
Zfish   451 FSGLHELRVLDLQENPIIYIEPKSF--------------------GHFTNLSSFLLGDL------ 489

  Fly   628 SFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLND 692
                 :.|..:..:.||      ||:.||:                       ||.::..:|::.
Zfish   490 -----NFPPNMSLIKLH------LSDIFGV-----------------------IPYNLSNVFISS 520

  Fly   693 NLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWL 757
            .|    .|...:..:|.|     .|....|.||...::                  ..|||...|
Zfish   521 GL----RPMHLVIGSNTT-----LNNGLNLHIKGQYVI------------------VEDCNSLLL 558

  Fly   758 QKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDC 822
            ..:         ..:.::..|....|.....|:|.:.:                   .||.
Zfish   559 TSV---------FTLQIQAAYMICENEFIGKYVPSVVS-------------------LEFQ---- 591

  Fly   823 EMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAV 887
                    :.|.|.....:::                         |..|.|        |.|.
Zfish   592 --------SMFSDNIGDLSVI-------------------------NQLVHL--------KTLK- 614

  Fly   888 LYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGS-- 950
                              |::|.:.:|.:..|:      ||||..|..|.|.:.|:..: :||
Zfish   615 ------------------LEKLDLTNLPNMDIM------FHNLTKLETLILANCKLFFL-DGSLT 654

  Fly   951 --FQMLRKLEVLRLDGNRLMHFEVWQLS--ANPYLVEISLADNQWSCECGYLARFRNYLGQSSEK 1011
              .:.|.||.::..|...::...|..|:  ...||.::.|   ..||:..:|..:
Zfish   655 KDLKALTKLGLIPKDTVNILQTFVDHLTQLRFVYLEDLDL---YCSCDNAWLVSW---------- 706

  Fly  1012 IIDASRVSCIYNNATSVLREKNGTKCTLRDGVAH-----YMHTNEIEGLLPLLLVATCAFVAFFG 1071
            |.|..:|..:.:|.:     ....||...:.|.|     |:..|....|..:....:..|:..|.
Zfish   707 IRDNRKVEVVMSNPS-----MQDLKCLTDNEVDHISFVSYVTENCSFDLDFVFFACSSVFLCIFI 766

  Fly  1072 LIFGLFCYRHE-LKIWAHSTNCLMNFCYKSPRFVDQLDKERPN---DAYFAYSLQDEHFVNQILA 1132
            ::..::.:..: .|.:.|..:......::.        ||:..   ||:.:||.:|||:|.:.|.
Zfish   767 VVVLMYKFVGQYFKPFYHIASGWFREAFRM--------KEKQQYRYDAFVSYSSKDEHWVIEELL 823

  Fly  1133 QTLENDIG---YRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHE 1194
            ..||.. |   .|||||.||..:...|.:.:.::..::::.:.::|:|:|.:.|...|.:.|.:.
Zfish   824 PNLEQR-GPPFLRLCLHSRDFQLGHDIVENITDSIYASRRTLCLVSRNYLNSNWCSVEMQLATYR 887

  Fly  1195 L-VKRRKRVVFILYGDLPQRDIDMDMR--HYLRTSTCIEWDDKK-----FWQKL 1240
            | |:.|..::.:....:|.|.:....|  ..::|.|.::|..:.     ||.:|
Zfish   888 LQVEHRDILILVFLETIPSRLLSSHHRLARLVKTRTYLDWPQESKMHEAFWDRL 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		LRR_8	171..236	CDD:290566	12/64 (19%)
		leucine-rich repeat	172..201	CDD:275380	4/28 (14%)
		leucine-rich repeat	202..278	CDD:275380	20/76 (26%)
		leucine-rich repeat	229..249	CDD:275380	3/20 (15%)
		LRR_RI	278..468	CDD:238064	45/203 (22%)
		leucine-rich repeat	279..302	CDD:275380	8/30 (27%)
		LRR_8	301..386	CDD:290566	18/88 (20%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	4/26 (15%)
		LRR	350..729	CDD:227223	92/431 (21%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	5/24 (21%)
		LRR_RI	<401..626	CDD:238064	63/277 (23%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	3/22 (14%)
		leucine-rich repeat	450..473	CDD:275380	4/24 (17%)
		leucine-rich repeat	474..497	CDD:275380	6/30 (20%)
		leucine-rich repeat	498..518	CDD:275380	6/49 (12%)
		leucine-rich repeat	521..544	CDD:275380	11/22 (50%)
		leucine-rich repeat	545..566	CDD:275380	8/20 (40%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	3/21 (14%)
		leucine-rich repeat	616..637	CDD:275380	2/20 (10%)
		leucine-rich repeat	638..662	CDD:275380	6/23 (26%)
		leucine-rich repeat	663..684	CDD:275380	2/20 (10%)
		leucine-rich repeat	685..708	CDD:275380	3/22 (14%)
		leucine-rich repeat	709..728	CDD:275380	5/18 (28%)
		LRR_8	883..943	CDD:290566	13/59 (22%)
		leucine-rich repeat	885..908	CDD:275380	2/22 (9%)
		leucine-rich repeat	909..932	CDD:275380	7/22 (32%)
		LRR_8	932..990	CDD:290566	15/63 (24%)
		leucine-rich repeat	933..956	CDD:275380	7/26 (27%)
		TIR	1114..1247	CDD:214587	38/138 (28%)
LOC572462	XP_005167813.2	leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..253	CDD:275380	15/77 (19%)
		leucine-rich repeat	254..350	CDD:275380	26/112 (23%)
		LRR_8	408..467	CDD:316378	24/58 (41%)
		leucine-rich repeat	409..432	CDD:275378	11/22 (50%)
		PLN00113	<427..>516	CDD:331614	34/148 (23%)
		leucine-rich repeat	433..456	CDD:275378	9/22 (41%)
		leucine-rich repeat	457..480	CDD:275378	10/42 (24%)
		leucine-rich repeat	541..584	CDD:275380	10/69 (14%)
		leucine-rich repeat	585..609	CDD:275380	5/79 (6%)
		leucine-rich repeat	610..635	CDD:275380	11/57 (19%)
		leucine-rich repeat	636..659	CDD:275380	6/23 (26%)
		TIR	803..941	CDD:214587	37/138 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920