DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Lgi1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_064674.1	Gene:	Lgi1 / 56839	MGIID:	1861691	Length:	557	Species:	Mus musculus

Alignment Length:	620	Identity:	128/620 - (20%)
Similarity:	215/620 - (34%)	Gaps:	209/620 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 CSALQDLNLNGNQL-KTVPLALRNMRHLRT--VDLGE----------------NMITVMEDSAFK 540
            ||....|..|...: :|||..:.::..:|:  .::.|                |...|:.|.||.
Mouse    48 CSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFI 112

  Fly   541 GLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELN- 604
            ||.:|..|.:..|.:::|:.||||.|.:|..|:||.|.:..:....|:...|:..|.|.||..|
Mouse   113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNAFNC 177

  Fly   605 DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLH--------KNRLSSLS--------N 653
            |.        .|.||      :|..  ||..:|::  |::        |.:::|||        .
Mouse   178 DC--------KLKWL------VEWL--GHTNATVE--DIYCEGPPEYKKRKINSLSPKDFDCIIT 224

  Fly   654 RFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQ 718
            .|....:|..|:|.:                                |||.          |.|.
Mouse   225 EFAKSQDLPYQSLSI--------------------------------DTFS----------YLND 247

  Fly   719 ITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDC-NIDWLQKINHI--TSRQYPRIMDLETIYCK 780
                                 |:.:...|||..| .::|    :|:  |.|.|..|....|:.||
Mouse   248 ---------------------EYVVIAQPFTGKCIFLEW----DHVEKTFRNYDNITGTSTVVCK 287

  Fly   781 LLNNRERAYIPLIEAE---PKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFH-DQTWSTN 841
            .:....:.|:  |.|:   ..|.   ||...||.......|....::..|.:...|. :..|...
Mouse   288 PIVIDTQLYV--IVAQLFGGSHI---YKRDGFANKFIKIQDIEVLKIRKPNDIETFKIEDNWYFV 347

  Fly   842 IVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAG-HSF----------LGRKNLA-----VLYA 890
            :.:.|.|.:          |:....:||.|..... |::          :.|..||     ::.:
Mouse   348 VADSSKAGF----------TTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLALRTPHLILS 402

  Fly   891 NNSNVAHIYNTTFSGLKRLL-----ILHLEDNHII---SLEGNEFHNLENLRELYLQSNKIASIA 947
            ::|....||.  :|...:|.     |.::||.:.:   |::|:.:..|..    ::..:|:....
Mouse   403 SSSQRPVIYQ--WSKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTR----FIGDSKVMKWG 461

  Fly   948 NGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLV---EISLAD-NQWSCECGYLARF------- 1001
            ..|||     ::.|:.....|.|:..|::...|.:   :.|... ..|..|.....:|
Mouse   462 GSSFQ-----DIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQA 521

  Fly  1002 -----------RNYLGQSSEK---------IIDAS 1016
                       ||:|..||.|         |:|.|
Mouse   522 PRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLS 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223	59/269 (22%)
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064	41/150 (27%)
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380	1/1 (100%)
		leucine-rich repeat	498..518	CDD:275380	5/20 (25%)
		leucine-rich repeat	521..544	CDD:275380	9/40 (23%)
		leucine-rich repeat	545..566	CDD:275380	8/20 (40%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	6/22 (27%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	6/39 (15%)
		leucine-rich repeat	663..684	CDD:275380	2/20 (10%)
		leucine-rich repeat	685..708	CDD:275380	3/22 (14%)
		leucine-rich repeat	709..728	CDD:275380	2/18 (11%)
		LRR_8	883..943	CDD:290566	13/72 (18%)
		leucine-rich repeat	885..908	CDD:275380	6/27 (22%)
		leucine-rich repeat	909..932	CDD:275380	7/30 (23%)
		LRR_8	932..990	CDD:290566	10/61 (16%)
		leucine-rich repeat	933..956	CDD:275380	4/22 (18%)
		TIR	1114..1247	CDD:214587
Lgi1	NP_064674.1	leucine-rich repeat	71..92	CDD:275378	2/20 (10%)
		LRR_8	91..151	CDD:316378	21/59 (36%)
		LRR 1	92..113		5/20 (25%)
		leucine-rich repeat	93..116	CDD:275378	7/22 (32%)
		LRR 2	116..137		7/20 (35%)
		leucine-rich repeat	117..140	CDD:275378	9/22 (41%)
		LRR 3	140..161		6/20 (30%)
		leucine-rich repeat	141..164	CDD:275378	6/22 (27%)
		PCC	146..>221	CDD:188093	23/92 (25%)
		leucine-rich repeat	165..177	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	225..267		15/108 (14%)
		EPTP	225..266	CDD:309018	15/107 (14%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	271..313		13/46 (28%)
		EPTP	272..312	CDD:309018	12/44 (27%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	317..364		7/56 (13%)
		EPTP	317..363	CDD:309018	7/55 (13%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	366..415		8/50 (16%)
		EPTP	366..414	CDD:309018	8/49 (16%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	419..462		8/46 (17%)
		EPTP	420..460	CDD:309018	7/43 (16%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	464..506		10/46 (22%)
		EPTP	464..505	CDD:309018	9/45 (20%)
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	510..552		7/41 (17%)
		EPTP	510..550	CDD:309018	7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000