Protein Alignment Toll-6 and LOC5666799

DIOPT Version :10

• Sequence 1: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: XP_061499947.1
• Gene: LOC5666799 / 5666799
• VectorBaseID: AGAMI1_007965
• Length: 574
• Species: Anopheles gambiae
• Alignment Length: 682
• Identity: 158/682 - (23%)
• Similarity: 257/682 - (37%)
• Gaps: 194/682 - (28%)

  Fly   103 VNSEFDTTNFSVIPAEHTIALHI-LCNDEIMAKSRLEAQSFAHLVRL-----QQLSIQYCKLGRL 161
            |.|..:.:.|:|     .:.||| .|..|:....:.:.|...:|..|     ::|:.|.|.|...
Mosquito    32 VQSTVEWSGFNV-----QLMLHINRCQLEVTCSDKPDFQLLENLQNLPSFKFEELAYQNCPLPVG 91

  Fly   162 GRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLS--SNNIWSLPDNIFCTLS 224
            .:.::|.|..|                  ::....|..|||..:|.:  ||:: :|..::|..|.
Mosquito    92 NQSLVDLLSAL------------------LDPTELSSIRRLFFVDNAKLSNHV-TLGPHLFADLP 137

  Fly   225 ELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDF 289
            .|..|:|.                    |.|.......|..|...|        :.:||:...|
Mosquito   138 ALQVLSMK--------------------NSSRMPLDNPELFKYLRS--------VTWLDLREGD- 173

  Fly   290 VVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQE 354
                    |..|..::|              |..|..|..|.|:.|:::.|||||..:.
Mosquito   174 --------GGSRNSKML--------------LHTLTQLTTLELTENELITLPTELITDL------ 210

  Fly   355 VYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEI 419
                        |.|.|                                 |.|.||||.::|.
Mosquito   211 ------------PSLGS---------------------------------LTLYHNKLERIEQ-- 228

  Fly   420 FSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNAL 484
            |:||..|..|:|.:|:|:.:..|.|..:.||..|.|:.|||..|.:..|.....|::...||...
Mosquito   229 FADLPNLTSLDLTYNELDTLQEDVFDKLPNLTQLFLNSNKLTSLPSGLLKRNTKLTVFRADNQRG 293

  Fly   485 IG--VHPDAFRNCSALQDLNLNGNQLKTVPLAL-RNMRHLRTVDLGENMITVMEDSAFKGLGNLY 546
            .|  :..:.|...:.|:|::::..:|.|:...| .....|..::|.:|.:..:.::..:...||.
Mosquito   294 SGLVLGDELFAGLTMLEDVSVSNCKLTTLSAGLFTAASKLTKLNLSDNKLQSLPENLLRHSSNLK 358

  Fly   547 GLRLIGNYLENITMHT-FRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELN--DING 608
            .|.|..|.|.|....| .:....|:||||..|::..:.....:..:|::.:.|:.|:|.  |.:.
Mosquito   359 ELYLQNNELMNKLPDTLLQSATQLRILNLGHNKLTTLSKYLLDSKNSLEELHLEYNQLYMIDRDA 423

  Fly   609 LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSE------------L 661
            ..|...||..||:|.|::.               ||:|.    ::.|.||.:            .
Mosquito   424 FISQAQSLKMLNLSHNQVA---------------LHENG----TDVFYLDGKTYYISRTPFYILA 469

  Fly   662 KLQTLDVSFNQLQRIGP--SSIPNSIELLFLNDNLITTVDPDTF-MHKTNLTRVDLYANQITTLD 723
            :|..||:|:|.:.:|..  .....|:..|.|:.||||.|....| ....|:.:|:|.:||||..|
Mosquito   470 RLTVLDLSYNAIVKIFKDFKGFMGSLRSLDLSHNLITNVSYANFPFLSPNIEQVNLQSNQITQYD 534

  Fly   724 IKSLRILPVWEHRALPEFYIGGNPFTC-DCNI 754
            :::..|.|                 || .|||
Mosquito   535 LRNNPIYP-----------------TCMPCNI 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733	23/113 (20%)
		leucine-rich repeat	148..171	CDD:275380	7/27 (26%)
		leucine-rich repeat	172..201	CDD:275380	2/28 (7%)
		LRR_8	200..>246	CDD:404697	12/47 (26%)
		leucine-rich repeat	202..278	CDD:275380	15/77 (19%)
		leucine-rich repeat	229..249	CDD:275380	2/19 (11%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR	299..654	CDD:443914	84/360 (23%)
		leucine-rich repeat	303..326	CDD:275380	3/22 (14%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		leucine-rich repeat	352..375	CDD:275380	3/22 (14%)
		leucine-rich repeat	376..401	CDD:275380	0/24 (0%)
		leucine-rich repeat	402..425	CDD:275380	10/22 (45%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	5/24 (21%)
		leucine-rich repeat	498..518	CDD:275380	5/20 (25%)
		leucine-rich repeat	521..544	CDD:275380	3/22 (14%)
		leucine-rich repeat	545..566	CDD:275380	7/21 (33%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	5/23 (22%)
		leucine-rich repeat	616..637	CDD:275380	5/20 (25%)
		leucine-rich repeat	638..662	CDD:275380	6/35 (17%)
		LRR_8	662..719	CDD:404697	19/59 (32%)
		leucine-rich repeat	663..684	CDD:275380	6/22 (27%)
		leucine-rich repeat	685..708	CDD:275380	8/23 (35%)
		leucine-rich repeat	709..728	CDD:275380	7/18 (39%)
		LRR	<863..>990	CDD:443914
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
LOC5666799	XP_061499947.1	None