DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and slit1a

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001030140.1 Gene:slit1a / 556123 ZFINID:ZDB-GENE-030722-3 Length:1524 Species:Danio rerio


Alignment Length:1156 Identity:266/1156 - (23%)
Similarity:425/1156 - (36%) Gaps:390/1156 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....|.|:.|....||:.||.|.|..:.|:      .:|..||...|.||||.|:.|.:.
Zfish    57 ERLELNGNNLTRINRNDFTGLKYLRVLQLMENQIV------TVERGAFDEMRELERLRLNRNQLH 115

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            .||:.:|...:.||.|::|||.:|.:....||        |:|:..:.     :...:..||..|
Zfish   116 QLPELLFQKNAALSRLDLSENFIQAIPRKAFR--------GATDIKNL-----QLDKNHISCIED 167

  Fly   279 --------LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKN--------- 326
                    ||.|.:::|:...:|.:.|..:.:||...:::|  :::.|..||.|..         
Zfish   168 GAFRAMRGLEVLTLNNNNISSIPVSSFNHMPKLRTFRLHSN--NLVCDCVLSWLSQWLRERPNIG 230

  Fly   327 ----------LQILNLS----------------------------------SNKIV--------- 338
                      |:.||::                                  :|.||         
Zfish   231 LFTQCSSPAPLRGLNVAEVQKHEFSCSGQSDSAVGQSCSLSSGSCPAVCSCNNNIVDCRGKGPTL 295

  Fly   339 ---ALP---TELFAEQAKI-------------IQEVYLQNNSISVLNPQLFSNLDQLQALDLSMN 384
               :||   ||:..||..|             ::.:.|.||.||.|.|..|..|..|.:|.|..|
Zfish   296 IPSSLPDSMTEIRLEQNSIKSIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGN 360

  Fly   385 QITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNN 449
            :||.  :.:..|.||..|.||.|:.||:..|....|.||..|.:|:|..|:::.:|..||:.:..
Zfish   361 KITD--LPRGVFDGLHALQLLLLNANKIHCLRANTFQDLQNLSLLSLYDNKIQTLAKGTFSSLRA 423

  Fly   450 LHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALIGVHPDAFRNCSA----- 497
            :.||.|:.|      .||:|..|      ..:|....|...|.|..:..:....|| |||     
Zfish   424 IQTLHLAQNPFICDCNLKWLADYLRSNPIETSGARCTSPRRLANKRIGQIKSKKFR-CSAKEQYA 487

  Fly   498 ---LQDLNLNG--NQLKTVPLALR---------NMRHLRTVD----------LGENMITVMEDSA 538
               .:|..||.  |.....|...|         |:|..|..:          |..|.||.:|   
Zfish   488 IPGTEDSRLNNDCNNDPVCPAKCRCESNVVDCSNLRLDRIPEHVPASTTEPRLNNNEITTIE--- 549

  Fly   539 FKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNEL 603
                                .|..|:.|.:|:.:||:.|:|:.:|.||||..||:..:.|..|:|
Zfish   550 --------------------AMGAFKTLTHLKKINLSNNKISEIEDGAFEGASSVNELHLTANQL 594

  Fly   604 NDI--NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTL 666
             |:  :|:|..:..|..|.:.:||:..              :|.|..:.|.|             
Zfish   595 -DLAHSGMFRGLEGLRMLMLRNNRISC--------------IHNNSFTGLHN------------- 631

  Fly   667 DVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILP 731
                              :.||.|.||.:||:.|..|....:|:.::|.|               
Zfish   632 ------------------VRLLSLYDNTLTTIAPGAFDTLQSLSTLNLLA--------------- 663

  Fly   732 VWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAY------- 789
                          |||.|:|.:.||.  :.:.:|             |::....|.:       
Zfish   664 --------------NPFNCNCRLAWLS--SWLRNR-------------KIVTGNPRCHRPAFLKE 699

  Fly   790 IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMP 854
            |||.:.....|.|. ..|        |..:|...:.||.:|||..      ::|.||......:|
Zfish   700 IPLQDVAAPDFRCE-DDH--------EDVSCAPPVHCPADCTCLE------SVVRCSNKHLQALP 749

  Fly   855 RRVPMDTSELYIDGNNF----VELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLE 915
            :..|.:.:|||:|||..    .||:  ||   |:|.::..:|:.::.:.|::|:.:.:|..|.|.
Zfish   750 KGTPRNITELYLDGNQLSTVPKELS--SF---KSLQLVDLSNNRISSLTNSSFTNMSQLTTLILS 809

  Fly   916 DNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEV---WQLS- 976
            .|.:..:....|..|.:||.|.|..|.|:.:.:|.|...:.|..|.:..|.| |.:.   | || 
Zfish   810 YNALRCIPTLAFSGLRSLRLLSLHGNDISELPDGIFSDAQSLSHLAIGANPL-HCDCGLRW-LSD 872

  Fly   977 --------------ANPYLVEISL--------------AD----------------NQWSCECGY 997
                          |:|:.:|..|              .|                :|..||...
Zfish   873 WVKTGYKEPGIARCASPHGMEGKLLLTTPAKRFECQGEVDSAILAKCNPCASGPCLHQGVCEADQ 937

  Fly   998 LARFR-----NYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLP 1057
            ...:|     .:.|::.|.:::|    |:....      |||..|        ::.|:|.||.  
Zfish   938 TDSYRCRCADGFKGKNCETVVNA----CVSEPC------KNGGTC--------HVSTDEDEGY-- 982

  Fly  1058 LLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLD 1108
                 :|:..|.|.   |..|.       ..:..|..|.|......:|.::
Zfish   983 -----SCSCAAGFE---GPSCE-------VDTDECRDNDCQNGATCIDGIN 1018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 6/21 (29%)
LRR_8 171..236 CDD:290566 24/64 (38%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
leucine-rich repeat 202..278 CDD:275380 22/75 (29%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 70/290 (24%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 301..386 CDD:290566 33/165 (20%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 12/71 (17%)
LRR 350..729 CDD:227223 108/434 (25%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 9/24 (38%)
LRR_RI <401..626 CDD:238064 72/267 (27%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 9/34 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 6/30 (20%)
leucine-rich repeat 521..544 CDD:275380 6/32 (19%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 10/22 (45%)
leucine-rich repeat 593..615 CDD:275380 6/23 (26%)
leucine-rich repeat 616..637 CDD:275380 4/20 (20%)
leucine-rich repeat 638..662 CDD:275380 4/23 (17%)
leucine-rich repeat 663..684 CDD:275380 0/20 (0%)
leucine-rich repeat 685..708 CDD:275380 9/22 (41%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 16/59 (27%)
leucine-rich repeat 885..908 CDD:275380 4/22 (18%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 21/105 (20%)
leucine-rich repeat 933..956 CDD:275380 8/22 (36%)
TIR 1114..1247 CDD:214587
slit1aNP_001030140.1 LRRNT 26..57 CDD:214470 266/1156 (23%)
leucine-rich repeat 36..55 CDD:275380
LRR_8 54..114 CDD:290566 21/62 (34%)
leucine-rich repeat 56..79 CDD:275380 6/21 (29%)
leucine-rich repeat 80..103 CDD:275380 8/28 (29%)
LRR_8 102..162 CDD:290566 21/72 (29%)
LRR_RI <104..227 CDD:238064 36/137 (26%)
leucine-rich repeat 104..127 CDD:275380 9/22 (41%)
leucine-rich repeat 128..151 CDD:275380 10/30 (33%)
leucine-rich repeat 152..175 CDD:275380 3/27 (11%)
LRR_8 153..210 CDD:290566 12/63 (19%)
leucine-rich repeat 176..199 CDD:275380 6/22 (27%)
leucine-rich repeat 200..327 CDD:275380 20/128 (16%)
TPKR_C2 208..257 CDD:301599 8/50 (16%)
LRRNT 275..306 CDD:214470 5/30 (17%)
LRR_8 303..362 CDD:290566 18/58 (31%)
LRR_4 326..366 CDD:289563 15/41 (37%)
leucine-rich repeat 328..351 CDD:275380 9/22 (41%)
LRR_8 350..434 CDD:290566 30/85 (35%)
leucine-rich repeat 352..372 CDD:275380 7/21 (33%)
LRR_RI <394..620 CDD:238064 66/250 (26%)
leucine-rich repeat 400..423 CDD:275380 7/22 (32%)
leucine-rich repeat 424..521 CDD:275380 23/97 (24%)
leucine-rich repeat 522..559 CDD:275380 10/59 (17%)
LRR_8 558..618 CDD:290566 21/60 (35%)
leucine-rich repeat 560..583 CDD:275380 10/22 (45%)
leucine-rich repeat 584..607 CDD:275380 6/23 (26%)
LRR_8 607..666 CDD:290566 21/132 (16%)
leucine-rich repeat 608..631 CDD:275380 7/36 (19%)
leucine-rich repeat 632..653 CDD:275380 9/20 (45%)
leucine-rich repeat 656..747 CDD:275380 29/149 (19%)
LRRCT 664..712 CDD:214507 14/62 (23%)
leucine-rich repeat 748..778 CDD:275380 12/34 (35%)
LRR_8 754..813 CDD:290566 19/63 (30%)
LRR_4 755..794 CDD:289563 13/43 (30%)
LRR_4 777..820 CDD:289563 9/42 (21%)
leucine-rich repeat 779..802 CDD:275380 4/22 (18%)
leucine-rich repeat 803..823 CDD:275380 5/19 (26%)
leucine-rich repeat 827..850 CDD:275380 8/22 (36%)
LRRCT 859..908 CDD:214507 10/50 (20%)
EGF_CA 920..955 CDD:238011 5/34 (15%)
EGF_CA 958..996 CDD:238011 14/65 (22%)
EGF_CA 998..1034 CDD:238011 4/21 (19%)
EGF_CA 1078..1112 CDD:238011
LamG 1179..1312 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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