DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and slit1a

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001030140.1 Gene:slit1a / 556123 ZFINID:ZDB-GENE-030722-3 Length:1524 Species:Danio rerio


Alignment Length:1156 Identity:266/1156 - (23%)
Similarity:425/1156 - (36%) Gaps:390/1156 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....|.|:.|....||:.||.|.|..:.|:      .:|..||...|.||||.|:.|.:.
Zfish    57 ERLELNGNNLTRINRNDFTGLKYLRVLQLMENQIV------TVERGAFDEMRELERLRLNRNQLH 115

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            .||:.:|...:.||.|::|||.:|.:....||        |:|:..:.     :...:..||..|
Zfish   116 QLPELLFQKNAALSRLDLSENFIQAIPRKAFR--------GATDIKNL-----QLDKNHISCIED 167

  Fly   279 --------LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKN--------- 326
                    ||.|.:::|:...:|.:.|..:.:||...:::|  :::.|..||.|..         
Zfish   168 GAFRAMRGLEVLTLNNNNISSIPVSSFNHMPKLRTFRLHSN--NLVCDCVLSWLSQWLRERPNIG 230

  Fly   327 ----------LQILNLS----------------------------------SNKIV--------- 338
                      |:.||::                                  :|.||         
Zfish   231 LFTQCSSPAPLRGLNVAEVQKHEFSCSGQSDSAVGQSCSLSSGSCPAVCSCNNNIVDCRGKGPTL 295

  Fly   339 ---ALP---TELFAEQAKI-------------IQEVYLQNNSISVLNPQLFSNLDQLQALDLSMN 384
               :||   ||:..||..|             ::.:.|.||.||.|.|..|..|..|.:|.|..|
Zfish   296 IPSSLPDSMTEIRLEQNSIKSIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGN 360

  Fly   385 QITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNN 449
            :||.  :.:..|.||..|.||.|:.||:..|....|.||..|.:|:|..|:::.:|..||:.:..
Zfish   361 KITD--LPRGVFDGLHALQLLLLNANKIHCLRANTFQDLQNLSLLSLYDNKIQTLAKGTFSSLRA 423

  Fly   450 LHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALIGVHPDAFRNCSA----- 497
            :.||.|:.|      .||:|..|      ..:|....|...|.|..:..:....|| |||     
Zfish   424 IQTLHLAQNPFICDCNLKWLADYLRSNPIETSGARCTSPRRLANKRIGQIKSKKFR-CSAKEQYA 487

  Fly   498 ---LQDLNLNG--NQLKTVPLALR---------NMRHLRTVD----------LGENMITVMEDSA 538
               .:|..||.  |.....|...|         |:|..|..:          |..|.||.:|   
Zfish   488 IPGTEDSRLNNDCNNDPVCPAKCRCESNVVDCSNLRLDRIPEHVPASTTEPRLNNNEITTIE--- 549

  Fly   539 FKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNEL 603
                                .|..|:.|.:|:.:||:.|:|:.:|.||||..||:..:.|..|:|
Zfish   550 --------------------AMGAFKTLTHLKKINLSNNKISEIEDGAFEGASSVNELHLTANQL 594

  Fly   604 NDI--NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTL 666
             |:  :|:|..:..|..|.:.:||:..              :|.|..:.|.|             
Zfish   595 -DLAHSGMFRGLEGLRMLMLRNNRISC--------------IHNNSFTGLHN------------- 631

  Fly   667 DVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILP 731
                              :.||.|.||.:||:.|..|....:|:.::|.|               
Zfish   632 ------------------VRLLSLYDNTLTTIAPGAFDTLQSLSTLNLLA--------------- 663

  Fly   732 VWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAY------- 789
                          |||.|:|.:.||.  :.:.:|             |::....|.:       
Zfish   664 --------------NPFNCNCRLAWLS--SWLRNR-------------KIVTGNPRCHRPAFLKE 699

  Fly   790 IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMP 854
            |||.:.....|.|. ..|        |..:|...:.||.:|||..      ::|.||......:|
Zfish   700 IPLQDVAAPDFRCE-DDH--------EDVSCAPPVHCPADCTCLE------SVVRCSNKHLQALP 749

  Fly   855 RRVPMDTSELYIDGNNF----VELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLE 915
            :..|.:.:|||:|||..    .||:  ||   |:|.::..:|:.::.:.|::|:.:.:|..|.|.
Zfish   750 KGTPRNITELYLDGNQLSTVPKELS--SF---KSLQLVDLSNNRISSLTNSSFTNMSQLTTLILS 809

  Fly   916 DNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEV---WQLS- 976
            .|.:..:....|..|.:||.|.|..|.|:.:.:|.|...:.|..|.:..|.| |.:.   | || 
Zfish   810 YNALRCIPTLAFSGLRSLRLLSLHGNDISELPDGIFSDAQSLSHLAIGANPL-HCDCGLRW-LSD 872

  Fly   977 --------------ANPYLVEISL--------------AD----------------NQWSCECGY 997
                          |:|:.:|..|              .|                :|..||...
Zfish   873 WVKTGYKEPGIARCASPHGMEGKLLLTTPAKRFECQGEVDSAILAKCNPCASGPCLHQGVCEADQ 937

  Fly   998 LARFR-----NYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLP 1057
            ...:|     .:.|::.|.:::|    |:....      |||..|        ::.|:|.||.  
Zfish   938 TDSYRCRCADGFKGKNCETVVNA----CVSEPC------KNGGTC--------HVSTDEDEGY-- 982

  Fly  1058 LLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLD 1108
                 :|:..|.|.   |..|.       ..:..|..|.|......:|.::
Zfish   983 -----SCSCAAGFE---GPSCE-------VDTDECRDNDCQNGATCIDGIN 1018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733 31/92 (34%)
leucine-rich repeat 148..171 CDD:275380 6/21 (29%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
LRR_8 200..>246 CDD:404697 18/45 (40%)
leucine-rich repeat 202..278 CDD:275380 22/75 (29%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR 299..654 CDD:443914 114/478 (24%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 12/71 (17%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 9/24 (38%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 9/34 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 6/30 (20%)
leucine-rich repeat 521..544 CDD:275380 6/32 (19%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 10/22 (45%)
leucine-rich repeat 593..615 CDD:275380 6/23 (26%)
leucine-rich repeat 616..637 CDD:275380 4/20 (20%)
leucine-rich repeat 638..662 CDD:275380 4/23 (17%)
LRR_8 662..719 CDD:404697 12/56 (21%)
leucine-rich repeat 663..684 CDD:275380 0/20 (0%)
leucine-rich repeat 685..708 CDD:275380 9/22 (41%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR <863..>990 CDD:443914 42/178 (24%)
leucine-rich repeat 885..908 CDD:275380 4/22 (18%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
leucine-rich repeat 933..956 CDD:275380 8/22 (36%)
TIR 1114..1247 CDD:214587
slit1aNP_001030140.1 LRR <25..>245 CDD:443914 52/208 (25%)
leucine-rich repeat 36..55 CDD:275380
leucine-rich repeat 56..79 CDD:275380 6/21 (29%)
leucine-rich repeat 80..103 CDD:275380 8/28 (29%)
leucine-rich repeat 104..127 CDD:275380 9/22 (41%)
leucine-rich repeat 128..151 CDD:275380 10/30 (33%)
leucine-rich repeat 152..175 CDD:275380 3/27 (11%)
leucine-rich repeat 176..199 CDD:275380 6/22 (27%)
leucine-rich repeat 200..327 CDD:275380 20/128 (16%)
LRR <282..>454 CDD:443914 53/173 (31%)
leucine-rich repeat 328..351 CDD:275380 9/22 (41%)
leucine-rich repeat 352..372 CDD:275380 7/21 (33%)
leucine-rich repeat 400..423 CDD:275380 7/22 (32%)
leucine-rich repeat 424..521 CDD:275380 23/97 (24%)
LRR 515..>813 CDD:443914 96/430 (22%)
leucine-rich repeat 522..559 CDD:275380 10/59 (17%)
leucine-rich repeat 560..583 CDD:275380 10/22 (45%)
leucine-rich repeat 584..607 CDD:275380 6/23 (26%)
leucine-rich repeat 608..631 CDD:275380 7/36 (19%)
leucine-rich repeat 632..653 CDD:275380 9/20 (45%)
leucine-rich repeat 656..747 CDD:275380 29/149 (19%)
leucine-rich repeat 748..778 CDD:275380 12/34 (35%)
leucine-rich repeat 779..802 CDD:275380 4/22 (18%)
leucine-rich repeat 803..823 CDD:275380 5/19 (26%)
leucine-rich repeat 827..850 CDD:275380 8/22 (36%)
PCC 835..>907 CDD:188093 16/73 (22%)
EGF_CA 920..955 CDD:238011 5/34 (15%)
EGF_CA 958..996 CDD:238011 14/65 (22%)
EGF_CA 998..1034 CDD:238011 4/21 (19%)
EGF_CA 1078..1112 CDD:238011
LamG 1179..1312 CDD:214598
Blue background indicates that the domain is not in the aligned region.

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