DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and LGI2

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_060646.2	Gene:	LGI2 / 55203	HGNCID:	18710	Length:	545	Species:	Homo sapiens

Alignment Length:	500	Identity:	100/500 - (20%)
Similarity:	174/500 - (34%)	Gaps:	171/500 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||..|:|..:.      :.|.|:::  :||.||.|.|.|.:....|.|:....|....:|.:|..
Human    36 CPATCSCTKES------IICVGSSW--VPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLL 92

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            |:::...|.:..|:||..|..|.:|.|.|.::..|.|..|.:|..|.|.:|.|.::....|..|.
Human    93 NSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLD 157

  Fly   956 KLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECG----YLARFRNYLGQSSEKIIDAS 1016
            .                        |:|:.|..|::.|:|.    ||     :|..::..:.|
Human   158 S------------------------LIELDLRGNKFECDCKAKWLYL-----WLKMTNSTVSD-- 191

  Fly  1017 RVSCI---------YNNATSVLREKNGTKCTLRDGVAH------------YMHTNEI-------- 1052
             |.||         .|:.||...|     ||..|.|.|            :...|::
Human   192 -VLCIGPPEYQEKKLNDVTSFDYE-----CTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPS 250

  Fly  1053 -EGLLPL-------------------------LLVATCAFVAFFGLIFGLFCYRHELKIWAHSTN 1091
             |..:.|                         :|:....||....|..|...|::: :.|.
Human   251 MENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYD-ESWT---- 310

  Fly  1092 CLMNFCYKSPRFVDQLDKE-----RPNDAYFAYSLQDEHFVNQILAQTLE---------NDIGYR 1142
                      :||...|.|     :|||... :.:.||.|.  ::|.:.:         |..|:
Human   311 ----------KFVKFQDIEVSRISKPNDIEL-FQIDDETFF--VIADSSKAGLSTVYKWNSKGF- 361

  Fly  1143 LCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNF---LYNEWSRFEYKSALHELVKRRKRVVF 1204
                |...:::.:..|...|..:...:..|:||...   :..:|::...|              |
Human   362 ----YSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKK--------------F 408

  Fly  1205 ILYGDLP-------------QRDIDMDMRHYLRTSTCIEWDDKKF 1236
            :.:||:|             |..:.:.:..::..|..:.|:.|:|
Human   409 VPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQF 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	19/59 (32%)
		leucine-rich repeat	885..908	CDD:275380	7/22 (32%)
		leucine-rich repeat	909..932	CDD:275380	8/22 (36%)
		LRR_8	932..990	CDD:290566	10/57 (18%)
		leucine-rich repeat	933..956	CDD:275380	7/22 (32%)
		TIR	1114..1247	CDD:214587	23/147 (16%)
LGI2	NP_060646.2	LRR 1	86..107		5/20 (25%)
		LRR_8	110..169	CDD:404697	19/82 (23%)
		LRR 2	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275378	8/22 (36%)
		LRR 3	134..155		6/20 (30%)
		leucine-rich repeat	135..158	CDD:275378	7/22 (32%)
		PCC	140..>215	CDD:188093	22/111 (20%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	219..261		6/41 (15%)
		EPTP	219..258	CDD:397689	5/38 (13%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	265..307		6/42 (14%)
		EPTP	266..304	CDD:397689	5/37 (14%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	311..358		11/49 (22%)
		EPTP	311..355	CDD:397689	11/46 (24%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	360..403		8/47 (17%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	407..450		8/56 (14%)
		EPTP	407..447	CDD:397689	7/53 (13%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	452..494		0/1 (0%)
		EPTP	452..491	CDD:397689	0/1 (0%)
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	498..540
		EPTP	499..537	CDD:397689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000