DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and LRRN3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001093128.1 Gene:LRRN3 / 54674 HGNCID:17200 Length:708 Species:Homo sapiens


Alignment Length:585 Identity:127/585 - (21%)
Similarity:249/585 - (42%) Gaps:128/585 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 LRNLTLRTHNILWPALNFEIEADAFSVTRRLE--RLDLSSNNIWSLPDNIFCTLSELSALNMSEN 234
            ::::.||.|.:|..|:...::|    |.::::  ||.......|..|.:|:...|.:        
Human     1 MKDMPLRIHVLLGLAITTLVQA----VDKKVDCPRLCTCEIRPWFTPRSIYMEASTV-------- 53

  Fly   235 RLQDVNELGFRD-RSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFG 298
               |.|:||... .::.|.|.......|...||            :||    ..||   |.|   
Human    54 ---DCNDLGLLTFPARLPANTQILLLQTNNIAK------------IEY----STDF---PVN--- 93

  Fly   299 TLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSIS 363
                |..|.::.|.:|.:.:..:..:..|..:.|..||:..||.:..:|.:. :||:|:.:|.:|
Human    94 ----LTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSN-LQELYINHNLLS 153

  Fly   364 VLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQI 428
            .::|                          ..|:||..|:.|:|:.|:|..:..:.|..|..|:|
Human   154 TISP--------------------------GAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEI 192

  Fly   429 LNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFR 493
            |.:..|.:..|....|.|:.||.:|:::.                ::|..:.:|||:|:      
Human   193 LMIGENPIIRIKDMNFKPLINLRSLVIAG----------------INLTEIPDNALVGL------ 235

  Fly   494 NCSALQDLNLNGNQLKTVP-LALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLEN 557
              ..|:.::...|:|..|| :||:.:.:|:.:||.:|.|..:....|..:.:|..|. |.|..|.
Human   236 --ENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELG-INNMPEL 297

  Fly   558 ITMHTFR--DLPNLQILNLARN-RIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLW 618
            |::.:..  :||:|:.:....| |::.:.|.||.....::::.|:.|.|:.: :|...::|:|..
Human   298 ISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362

  Fly   619 LNISDNRLESFDYGHVPSTLQWLDLHKN--RLSSLSNRFGLD-SELKLQTL-DVSFNQLQR---- 675
            ::|..|.:      .....::|::::|.  |.....:.|.:| .|.:.|.: .|.|..:..    
Human   363 ISIHSNPI------RCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLP 421

  Fly   676 -IGPSSIPNSIEL---LFLNDNLITTVDPDTFMHKTNLTRVDLYANQIT---------TLDIKSL 727
             |.|.|.|:::.:   .:::.:...|.:|...::....:...|..|.:|         ||||..:
Human   422 LIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGV 486

  Fly   728  727
            Human   487  486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566 13/65 (20%)
leucine-rich repeat 172..201 CDD:275380 7/28 (25%)
leucine-rich repeat 202..278 CDD:275380 15/78 (19%)
leucine-rich repeat 229..249 CDD:275380 4/20 (20%)
LRR_RI 278..468 CDD:238064 43/189 (23%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 301..386 CDD:290566 17/84 (20%)
leucine-rich repeat 303..326 CDD:275380 4/22 (18%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR 350..729 CDD:227223 88/404 (22%)
leucine-rich repeat 352..375 CDD:275380 6/22 (27%)
leucine-rich repeat 376..401 CDD:275380 3/24 (13%)
LRR_RI <401..626 CDD:238064 57/229 (25%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 2/22 (9%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 6/22 (27%)
leucine-rich repeat 545..566 CDD:275380 6/22 (27%)
leucine-rich repeat 569..592 CDD:275380 6/23 (26%)
leucine-rich repeat 593..615 CDD:275380 4/22 (18%)
leucine-rich repeat 616..637 CDD:275380 3/20 (15%)
leucine-rich repeat 638..662 CDD:275380 6/26 (23%)
leucine-rich repeat 663..684 CDD:275380 7/26 (27%)
leucine-rich repeat 685..708 CDD:275380 2/25 (8%)
leucine-rich repeat 709..728 CDD:275380 7/28 (25%)
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
LRRN3NP_001093128.1 LRRNT 28..72 CDD:214470 12/54 (22%)
LRR 1 70..91 8/39 (21%)
leucine-rich repeat 72..93 CDD:275380 8/39 (21%)
LRR <75..355 CDD:227223 82/357 (23%)
LRR 2 93..114 5/27 (19%)
leucine-rich repeat 94..117 CDD:275380 4/22 (18%)
LRR 3 117..138 6/20 (30%)
leucine-rich repeat 118..141 CDD:275380 7/22 (32%)
LRR 4 141..162 7/47 (15%)
leucine-rich repeat 142..165 CDD:275380 9/48 (19%)
LRR 5 165..186 6/20 (30%)
leucine-rich repeat 166..189 CDD:275380 7/22 (32%)
LRR 6 189..210 6/20 (30%)
leucine-rich repeat 190..213 CDD:275380 7/22 (32%)
LRR 7 213..234 7/36 (19%)
leucine-rich repeat 214..237 CDD:275380 7/46 (15%)
LRR 8 237..258 7/20 (35%)
leucine-rich repeat 238..261 CDD:275380 7/22 (32%)
LRR 9 261..282 6/20 (30%)
leucine-rich repeat 262..285 CDD:275380 6/22 (27%)
LRR 10 285..304 6/19 (32%)
leucine-rich repeat 286..310 CDD:275380 7/24 (29%)
LRR 11 310..332 6/21 (29%)
leucine-rich repeat 311..333 CDD:275380 6/21 (29%)
LRR 12 335..358 4/22 (18%)
leucine-rich repeat 336..359 CDD:275380 4/22 (18%)
PCC 341..>442 CDD:188093 21/106 (20%)
Ig 437..513 CDD:325142 9/50 (18%)
fn3 526..593 CDD:306538
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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