DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and TLR8

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1220 Identity:271/1220 - (22%)
Similarity:438/1220 - (35%) Gaps:392/1220 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 KKSSSSSTSCSLDLE----------------YLDVS---------------------HNDFVVLP 293
            |:||..::||||..|                :|.:|                     .||.|:..
Human     2 KESSLQNSSCSLGKETKKENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAE 66

  Fly   294 ANGFGTLRRLR-----------VLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALP------ 341
            .:.    |||:           .|.:::|.|:.|.:::..||:||..:||:.|..|...      
Human    67 CSN----RRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGI 127

  Fly   342 -------TELFAEQAKIIQEVYLQNNSISVLNPQLFSNL-DQLQALDLSMNQITSTWIDKNTFVG 398
                   |:......|.::|:.|::|.:    ||:.|.| :.|..|.|..|.|.:.     |..|
Human   128 QSNGLNITDGAFLNLKNLRELLLEDNQL----PQIPSGLPESLTELSLIQNNIYNI-----TKEG 183

  Fly   399 LIRLVLL-------NLSHNKL---TKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTL 453
            :.||:.|       |...||:   |.:|..:|..|..|::|:|..|.|.::....   .::|..|
Human   184 ISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL---PSSLRKL 245

  Fly   454 LLSHNKLKYLDAYALNGLYVLSLLSL-----------------DNNALIGVHPDAFRNCSALQDL 501
            .||:.::||:......||..|:||.|                 |..|.|.:...||:|.:.|:.|
Human   246 FLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYL 310

  Fly   502 NLNGNQLKTVPLA-LRNMRHLRTVDLGEN-MITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFR 564
            ||:...|:.:..| .:||.||:.:||..| ::..:...||                  :||    
Human   311 NLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAF------------------LTM---- 353

  Fly   565 DLPNLQILNLARNRIAVVEP------GAFEMTSSIQAVRLDG---NEL--NDINGLFSNMPSLLW 618
             ||.|:||:|:.|.|....|      ..|....|::|:.|.|   .||  :|...|. .:|:|..
Human   354 -LPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLM-QLPNLST 416

  Fly   619 LNISDNRLESFDYGHVP--STLQWLDLHKNRLSSL----------------------SNRFGLDS 659
            :|:..|.::..|:....  |.|:.:.|.:||:|.|                      |..|..|.
Human   417 INLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDP 481

  Fly   660 E----------LKLQ------TLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTN 708
            .          :|.|      .||:|.|.:..|||:...|..::..||                 
Human   482 HSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLN----------------- 529

  Fly   709 LTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMD 773
                 |.||       .:.::|...|..|:|                      |:.         
Human   530 -----LSAN-------SNAQVLSGTEFSAIP----------------------HVK--------- 551

  Fly   774 LETIYCKLLNNR-----ERAYIPLIEAEPKHFLCTYKTHCF---AVCHCCEFDACDCEMTCPTNC 830
                |..|.|||     ..|...|.:.|....  :|.:|.|   .|.|..||      :...||.
Human   552 ----YLDLTNNRLDFDNASALTELSDLEVLDL--SYNSHYFRIAGVTHHLEF------IQNFTNL 604

  Fly   831 TCF---HDQTW---------STNIVEC--SGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLG 881
            ...   |:..:         |.::||.  ||       .|:.:..::   |.|.::.:    |.|
Human   605 KVLNLSHNNIYTLTDKYNLESKSLVELVFSG-------NRLDILWND---DDNRYISI----FKG 655

  Fly   882 RKNLAVLYANNSNVAHIYNTTFSGLKRLLI-LHLEDN----------------HIISLEGNEFHN 929
            .|||..|..:.:.:.||.|..|..|...|. ||:.||                .::.|.||:...
Human   656 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLF 720

  Fly   930 L--------ENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRL--MHFEVWQLSANPYLVEI 984
            |        .:||.|.|..|:|:.:.:|....:..|:.|.|..|.|  ::....:......|..:
Human   721 LTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 785

  Fly   985 SLADNQWSCECGYLARFRNYLGQ----SSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAH 1045
            .|..|.:.|.|. :..||.::.:    ...:::|....|.......|::.               
Human   786 ELHGNPFECTCD-IGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVS--------------- 834

  Fly  1046 YMHTNEIEGLLPLLLVATC-----AFVAFFGLIF-----GLFCYRHELKIWAHSTNCLMNFCYKS 1100
                         |.:.||     |.:.||...|     .|....|.|..|  ....:.|.|...
Human   835 -------------LELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYW--DVWFIYNVCLAK 884

  Fly  1101 PRFVDQLDKERP-NDAYFAYSLQDEHFVNQILAQTLENDIGYR----------LCLHYRDVNINA 1154
            .:....|...:. .|||.:|..:|....:.::     |::.|.          |||..||.:...
Human   885 VKGYRSLSTSQTFYDAYISYDTKDASVTDWVI-----NELRYHLEESRDKNVLLCLEERDWDPGL 944

  Fly  1155 YITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKR-----RKRVVFILYGDLPQRD 1214
            .|.|.|:::...:|:.|.||:|.:. ..|:   :|:|.:..::|     ...::|||...:.|..
Human   945 AIIDNLMQSINQSKKTVFVLTKKYA-KSWN---FKTAFYLALQRLMDENMDVIIFILLEPVLQHS 1005

  Fly  1215 IDMDMRHYLRTSTCIEWDDKK-----FWQKLRLALPLPNGRGNNNKRVVS 1259
            ..:.:|..:..|:.::|.|..     |||.||..:...|....||..|.|
Human  1006 QYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDS 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 6/11 (55%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 58/261 (22%)
leucine-rich repeat 279..302 CDD:275380 6/59 (10%)
LRR_8 301..386 CDD:290566 28/109 (26%)
leucine-rich repeat 303..326 CDD:275380 7/33 (21%)
leucine-rich repeat 327..350 CDD:275380 6/35 (17%)
LRR 350..729 CDD:227223 113/459 (25%)
leucine-rich repeat 352..375 CDD:275380 7/23 (30%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
LRR_RI <401..626 CDD:238064 72/264 (27%)
leucine-rich repeat 402..425 CDD:275380 9/32 (28%)
leucine-rich repeat 426..449 CDD:275380 5/22 (23%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 10/39 (26%)
leucine-rich repeat 498..518 CDD:275380 6/20 (30%)
leucine-rich repeat 521..544 CDD:275380 6/23 (26%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 8/28 (29%)
leucine-rich repeat 593..615 CDD:275380 7/26 (27%)
leucine-rich repeat 616..637 CDD:275380 4/22 (18%)
leucine-rich repeat 638..662 CDD:275380 9/55 (16%)
leucine-rich repeat 663..684 CDD:275380 8/26 (31%)
leucine-rich repeat 685..708 CDD:275380 2/22 (9%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 23/84 (27%)
leucine-rich repeat 885..908 CDD:275380 7/22 (32%)
leucine-rich repeat 909..932 CDD:275380 9/47 (19%)
LRR_8 932..990 CDD:290566 14/59 (24%)
leucine-rich repeat 933..956 CDD:275380 7/22 (32%)
TIR 1114..1247 CDD:214587 37/152 (24%)
TLR8NP_057694.2 LRR_8 83..155 CDD:290566 17/71 (24%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
leucine-rich repeat 107..144 CDD:275380 6/36 (17%)
leucine-rich repeat 145..165 CDD:275380 7/23 (30%)
leucine-rich repeat 166..189 CDD:275380 9/27 (33%)
leucine-rich repeat 190..220 CDD:275380 8/29 (28%)
leucine-rich repeat 221..241 CDD:275380 5/22 (23%)
LRR_8 240..317 CDD:290566 22/76 (29%)
leucine-rich repeat 242..265 CDD:275380 8/22 (36%)
leucine-rich repeat 266..306 CDD:275380 10/39 (26%)
LRR_8 305..367 CDD:290566 24/84 (29%)
leucine-rich repeat 307..330 CDD:275380 8/22 (36%)
leucine-rich repeat 331..356 CDD:275380 9/47 (19%)
leucine-rich repeat 387..413 CDD:275380 7/26 (27%)
LRR_8 412..>449 CDD:290566 10/36 (28%)
leucine-rich repeat 414..437 CDD:275380 4/22 (18%)
LRR_8 502..560 CDD:290566 22/121 (18%)
LRR_RI <504..719 CDD:238064 63/300 (21%)
leucine-rich repeat 504..524 CDD:275380 8/19 (42%)
leucine-rich repeat 525..549 CDD:275380 9/74 (12%)
LRR_8 548..614 CDD:290566 20/108 (19%)
leucine-rich repeat 550..573 CDD:275380 7/35 (20%)
leucine-rich repeat 574..603 CDD:275380 8/36 (22%)
leucine-rich repeat 604..658 CDD:275380 11/67 (16%)
LRR_8 657..718 CDD:290566 17/60 (28%)
leucine-rich repeat 659..683 CDD:275380 7/23 (30%)
leucine-rich repeat 684..707 CDD:275380 5/22 (23%)
LRR_8 706..766 CDD:290566 15/59 (25%)
leucine-rich repeat 708..730 CDD:275380 4/21 (19%)
leucine-rich repeat 732..755 CDD:275380 7/22 (32%)
leucine-rich repeat 756..775 CDD:275380 5/18 (28%)
LRRCT 790..835 CDD:214507 8/73 (11%)
TIR 898..1040 CDD:214587 37/150 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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