DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and TLR7

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:1198 Identity:256/1198 - (21%)
Similarity:422/1198 - (35%) Gaps:363/1198 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 LDLSSNNIWSLP-------DNIFCTLSELSALN-MSENRLQDVNELGFRDRSKEPTNGSTESTST 261
            :|.:..::..:|       .|:..|::.:..:: .|.:||..:.|:.||........||..:...
Human    49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCI 113

  Fly   262 TESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKN 326
            .....|..|.|....|...|||  .|..:.:|.   |....|::||:..|.|..|..:.|:.|.|
Human   114 KRLQIKPRSFSGLTYLKSLYLD--GNQLLEIPQ---GLPPSLQLLSLEANNIFSIRKENLTELAN 173

  Fly   327 --------------------------------LQILNLSSNKIVALPTELFAEQAKIIQEVYLQN 359
                                            |::|:|..|.:.|:||.|    ...:.|:||.|
Human   174 IEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVL----PSTLTELYLYN 234

  Fly   360 NSISVLNPQLFSNLDQLQALDLSMN---------------QITSTWIDKNTFVGLIRLVLLNLSH 409
            |.|:.:....|:||:|||.||||.|               ..:...|..|.|..|..|.:|.|..
Human   235 NMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHS 299

  Fly   410 NKLTKLEPEIFSDLYTLQILNLRHNQLENIAADT----FAPMNNLHTLLLSHNKLKYLDAYALNG 470
            |.|..:.|..|.::..||.|:|..|.|.....|.    |.|  :|..|.||.|            
Human   300 NSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLP--SLIQLDLSFN------------ 350

  Fly   471 LYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNG---NQLKTVPLA-LRNMRHLRTVDLGENMI 531
             :.|.:.....|.     ..||.:..:|:.|.:.|   .:||:..|: |.|:::|..:|||.|.|
Human   351 -FELQVYRASMNL-----SQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFI 409

  Fly   532 TVMEDSAFKGLGNLYGLRL-----------------------IGNYLENI--TMHTFR------- 564
            .:...|.||....|..:.|                       :.:|...:  .:|.||       
Human   410 KIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARS 474

  Fly   565 -DLPNL---------------QILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELND-INGL-FS 611
             ...|.               |.|:|::|.|..|:...|:..|.::.:.|.||.::. :||. |.
Human   475 CRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQ 539

  Fly   612 NMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQ--LQ 674
            .:..|.:|:.|:|||:.              ||......|.         ||:.||:|.|.  .|
Human   540 PLAELRYLDFSNNRLDL--------------LHSTAFEELH---------KLEVLDISSNSHYFQ 581

  Fly   675 RIGPSSIPN------SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVW 733
            ..|.:.:.|      .::.|.:|||                   |:.::...|::.:|||.|   
Human   582 SEGITHMLNFTKNLKVLQKLMMNDN-------------------DISSSTSRTMESESLRTL--- 624

  Fly   734 EHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPK 798
                  ||  .||    ..::.|.:..|.               |.:|..|       |::.|  
Human   625 ------EF--RGN----HLDVLWREGDNR---------------YLQLFKN-------LLKLE-- 653

  Fly   799 HFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRV----PM 859
                                    |:....|...|                   :|..|    |.
Human   654 ------------------------ELDISKNSLSF-------------------LPSGVFDGMPP 675

  Fly   860 DTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEG 924
            :...|.:..|.....:.......|||..|..:::.:..:.....:..:.|..|.|::|.|.||..
Human   676 NLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTK 740

  Fly   925 NEFHNLENLRELYLQSNKIASIANGSF--QMLRKLEVLRLDGNRLM-------------HFEVWQ 974
            ....:...||.|.|.||||..|...||  .:|..|::|.|..||.:             |.||  
Human   741 YFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEV-- 803

  Fly   975 LSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTL 1039
              ..|||                                 |:.|:|:...|      ..|.....
Human   804 --TIPYL---------------------------------ATDVTCVGPGA------HKGQSVIS 827

  Fly  1040 RDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFV 1104
            .|     ::|.|:: |..|:|.:....|:.|.::.....:.:...:|     .:.:||....:..
Human   828 LD-----LYTCELD-LTNLILFSLSISVSLFLMVMMTASHLYFWDVW-----YIYHFCKAKIKGY 881

  Fly  1105 DQLDKERPN---DAYFAYSLQDEHFVNQILAQ---TLEN--DIGYRLCLHYRDVNINAYITDALI 1161
            .:|..  |:   ||:..|..:|......:||:   .||:  :..:.|||..||......:.:.|.
Human   882 QRLIS--PDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLS 944

  Fly  1162 EAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLP-QRDIDMDMRHYLRT 1225
            ::.:.:|:.|.|::..:...|..:..:..:...|:..:..|:.:::.:.| |:...:.:|..|..
Human   945 QSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCG 1009

  Fly  1226 STCIEWDDKK-----FWQKLRLALPLPN 1248
            |:.:||....     |||.|:.||...|
Human  1010 SSVLEWPTNPQAHPYFWQCLKNALATDN 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566 5/38 (13%)
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 15/80 (19%)
leucine-rich repeat 229..249 CDD:275380 6/20 (30%)
LRR_RI 278..468 CDD:238064 65/240 (27%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 301..386 CDD:290566 34/131 (26%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
LRR 350..729 CDD:227223 110/459 (24%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 11/39 (28%)
LRR_RI <401..626 CDD:238064 67/282 (24%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 9/26 (35%)
leucine-rich repeat 450..473 CDD:275380 5/22 (23%)
leucine-rich repeat 474..497 CDD:275380 4/22 (18%)
leucine-rich repeat 498..518 CDD:275380 7/23 (30%)
leucine-rich repeat 521..544 CDD:275380 9/22 (41%)
leucine-rich repeat 545..566 CDD:275380 6/53 (11%)
leucine-rich repeat 569..592 CDD:275380 7/37 (19%)
leucine-rich repeat 593..615 CDD:275380 6/23 (26%)
leucine-rich repeat 616..637 CDD:275380 6/20 (30%)
leucine-rich repeat 638..662 CDD:275380 3/23 (13%)
leucine-rich repeat 663..684 CDD:275380 8/28 (29%)
leucine-rich repeat 685..708 CDD:275380 4/22 (18%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 17/59 (29%)
leucine-rich repeat 885..908 CDD:275380 2/22 (9%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
LRR_8 932..990 CDD:290566 23/72 (32%)
leucine-rich repeat 933..956 CDD:275380 12/24 (50%)
TIR 1114..1247 CDD:214587 33/143 (23%)
TLR7NP_057646.1 leucine-rich repeat 598..651 CDD:275380 20/108 (19%)
LRR 21 619..644 11/54 (20%)
leucine-rich repeat 621..643 CDD:275380 9/51 (18%)
LRR 22 649..672 7/67 (10%)
leucine-rich repeat 652..676 CDD:275380 7/68 (10%)
LRR 23 674..697 3/22 (14%)
leucine-rich repeat 677..700 CDD:275380 2/22 (9%)
LRR 24 698..721 4/22 (18%)
leucine-rich repeat 701..724 CDD:275380 2/22 (9%)
LRR 25 723..745 7/21 (33%)
leucine-rich repeat 725..748 CDD:275380 7/22 (32%)
LRR 26 746..769 11/22 (50%)
leucine-rich repeat 749..767 CDD:275380 9/17 (53%)
PCC 753..>837 CDD:188093 28/132 (21%)
LRR 27 772..795 6/22 (27%)
TIR 890..>993 CDD:214587 20/102 (20%)
LRR 1 43..64 2/14 (14%)
leucine-rich repeat 48..69 CDD:275380 2/19 (11%)
LRR 2 65..87 3/21 (14%)
LRR_8 75..139 CDD:404697 16/65 (25%)
leucine-rich repeat 91..128 CDD:275380 8/36 (22%)
LRR 3 110..126 3/15 (20%)
LRR 4 127..149 7/26 (27%)
leucine-rich repeat 129..173 CDD:275380 15/48 (31%)
LRR 5 151..170 6/18 (33%)
LRR 6 171..195 2/23 (9%)
PLN00113 191..>711 CDD:215061 143/667 (21%)
LRR 7 203..226 8/26 (31%)
leucine-rich repeat 206..225 CDD:275380 8/22 (36%)
leucine-rich repeat 227..250 CDD:275380 9/22 (41%)
LRR 8 228..247 7/18 (39%)
LRR 9 248..275 9/26 (35%)
leucine-rich repeat 251..291 CDD:275380 11/39 (28%)
LRR 10 289..312 8/22 (36%)
leucine-rich repeat 292..315 CDD:275380 7/22 (32%)
LRR 11 314..337 7/22 (32%)
leucine-rich repeat 316..341 CDD:275380 9/26 (35%)
LRR 12 339..368 10/48 (21%)
leucine-rich repeat 342..371 CDD:275380 9/46 (20%)
LRR 13 369..392 6/22 (27%)
leucine-rich repeat 372..398 CDD:275380 8/25 (32%)
LRR 14 396..419 8/22 (36%)
leucine-rich repeat 399..422 CDD:275380 9/22 (41%)
LRR 15 421..443 2/21 (10%)
LRR <488..775 CDD:227223 84/410 (20%)
LRR 16 492..515 7/22 (32%)
leucine-rich repeat 496..518 CDD:275380 7/21 (33%)
LRR 17 516..540 7/23 (30%)
leucine-rich repeat 519..543 CDD:275380 6/23 (26%)
LRR 18 541..564 8/36 (22%)
leucine-rich repeat 544..567 CDD:275380 9/45 (20%)
LRR 19 566..588 8/30 (27%)
leucine-rich repeat 568..597 CDD:275380 8/28 (29%)
LRR 20 595..618 6/41 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.780

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