DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Tlr11

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001138251.2	Gene:	Tlr11 / 498491	RGDID:	1564460	Length:	932	Species:	Rattus norvegicus

Alignment Length:	1145	Identity:	257/1145 - (22%)
Similarity:	415/1145 - (36%)	Gaps:	332/1145 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 SVTRRLERLDLSSNNI----WSLPDNI---------------FCTLSELSALNMSENRLQDVNEL 242
            ||...|..|.|.|.|:    |::||.|               ||||:....|..|.:.::::|:
  Rat    16 SVLLILILLTLVSLNLTGLAWTIPDCIIADSLLFPNLSSYIPFCTLAPRLHLLASCSNVKNINQ- 79

  Fly   243 GFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPAN---GFGTLRRLR 304
               ...|.|.|        ||.........|                  ||||   ||.:|:.||
  Rat    80 ---TLEKVPRN--------TEVLCLQGMVPT------------------LPANAFDGFYSLQLLR 115

  Fly   305 VLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQL 369
            :    ..|.:.|..:...||..||.|             .|...|.....::|..:|:..|.
  Rat   116 L----QLGTTNITSRTFQGLDQLQYL-------------FFEHHAPCCLSLFLPPDSLESLR--- 160

  Fly   370 FSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYT--------- 425
              :|..|......:....|.::...    |..|.:.|....||.:|: .:|.||..
  Rat   161 --SLSSLSFQGYCLTYSHSIYLPTT----LRHLTMRNSCLTKLQELQ-RLFPDLLLGASSTPNTK 218

  Fly   426 -----LQILNLRHN-QLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNAL 484
                 |::|:|.:| ||:.........: .||:|:|....|:.||              |.::.|
  Rat   219 PRTPFLEVLDLSYNLQLKQAGIRDLYGL-TLHSLILDGTPLRALD--------------LTSSGL 268

  Fly   485 IGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMI-TVMEDSAFKGLGNLYGL 548
            :.:|           .|:|.|..::.:|.::.....|..:|||:|.| .::.:....||..|..|
  Rat   269 LHLH-----------FLSLVGTGIEKLPASVTGFSELCALDLGKNQIQNILGNGDILGLKALKFL 322

  Fly   549 RLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNM 613
            .|..|:|:::.:...|.||.||.|||:.|::                    |..|....||||.
  Rat   323 SLHDNHLQSLPVRFLRTLPQLQKLNLSMNKL--------------------GPILELPEGLFST- 366

  Fly   614 PSLLWLNISDNRLESFDYGHVP--STLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRI 676
             :|..|::|.|:|.....|:..  |.||.|.|..|.:|||||. .|.....|:|||:|:||::.:
  Rat   367 -NLTVLDLSHNQLCEIPRGNFSFLSQLQELWLSGNNISSLSNE-SLQGLRWLRTLDLSWNQIKVL 429

  Fly   677 GPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVD-------LYANQITTLDIKSLRILPVWE 734
            .|..:.:...|..|  ||:     .|::...:.|::.       |......||:|..|....:..
  Rat   430 KPGWLSHLPALTTL--NLL-----GTYLEHISGTQLQGPKMLRHLQLGSFPTLEIYRLWFPMLLS 487

  Fly   735 HRALPEFYI-----GGNPFTCDCNIDWLQKINHI-----TSRQYP--RIMDLETIYCKLLNNRER 787
            .....|.||     .|.||....|:. |:..|.:     |:..:|  |.:.|......|..::.:
  Rat   488 LEIQAETYIQFMVPSGEPFLFLENLT-LETSNLLLEPKTTTIHFPSLRRLTLRGYSIFLSTSQLQ 551

  Fly   788 AYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSE 852
            ::.|     |:..|..|    |.| .|...||.|..:                          .|
  Rat   552 SFFP-----PQLPLLEY----FFV-WCRNDDAVDLHL--------------------------FE 580

  Fly   853 MPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDN 917
            |||                             |.||...|.|  ..|.::...|:.||
  Rat   581 MPR-----------------------------LRVLELGNLN--FFYESSTVKLEMLL------- 607

  Fly   918 HIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSAN---- 978
                   ||   :..|:.|.|....:.:::..||:.|:.|::|.|:..|.:     ::::|
  Rat   608 -------NE---VPQLQVLALSHLNLKNLSVSSFKGLQSLKLLLLNSERAL-----EMNSNLQEL 657

  Fly   979 -PYLVE-ISLADNQWSCEC------GYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGT 1035
             |.:.: :..:|..::|:|      .:..|..|......||.|..:..|   :.:.::|.....|
  Rat   658 IPQIPQYVYFSDVTFACQCETSWLESWATRAPNTFVYGLEKPICMANAS---DYSKTLLFSFLAT 719

  Fly  1036 KCTLRDGVAHYMHTNEIEGLLP----LLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNF 1096
            .|.         |..|..|.|.    |||:.....::         |::..   |.|....|.:.
  Rat   720 NCP---------HGTEFWGFLTSFSLLLLLIILPLIS---------CHKWS---WLHHLWTLFHT 763

  Fly  1097 CY---KSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLE----NDIGYRLCLHYRDVNINA 1154
            |:   ...|...|.:    .|.:.:|..:|:.:|.:.|...||    ...|.||||..||..|..
  Rat   764 CWWKLGGHRLRGQFN----YDVFISYCEEDQDWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGN 824

  Fly  1155 YITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDM 1219
            ...:::|.:...::..:.||:...|.:.|...|.:.|.:.|:.|......:|   |....:|...
  Rat   825 DRMESMIASMGKSRAILCVLTGQALASPWCNLELRLATYHLIARPGTTCLLL---LFLEPLDRQK 886

  Fly  1220 RH-YLRTSTCIEWDD-------KKFW--------QKLRLA 1243
            .| |.|.|..::.:|       |..|        |:||.|
  Rat   887 LHSYHRLSRWLQKEDYFDLSQGKMEWNTFCEQLKQRLRKA 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	17/57 (30%)
		leucine-rich repeat	172..201	CDD:275380	2/3 (67%)
		leucine-rich repeat	202..278	CDD:275380	22/94 (23%)
		leucine-rich repeat	229..249	CDD:275380	3/19 (16%)
		LRR_RI	278..468	CDD:238064	46/207 (22%)
		leucine-rich repeat	279..302	CDD:275380	7/25 (28%)
		LRR_8	301..386	CDD:290566	16/84 (19%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR	350..729	CDD:227223	100/403 (25%)
		leucine-rich repeat	352..375	CDD:275380	4/22 (18%)
		leucine-rich repeat	376..401	CDD:275380	3/24 (13%)
		LRR_RI	<401..626	CDD:238064	60/240 (25%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	6/23 (26%)
		leucine-rich repeat	450..473	CDD:275380	7/22 (32%)
		leucine-rich repeat	474..497	CDD:275380	3/22 (14%)
		leucine-rich repeat	498..518	CDD:275380	4/19 (21%)
		leucine-rich repeat	521..544	CDD:275380	8/23 (35%)
		leucine-rich repeat	545..566	CDD:275380	6/20 (30%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	6/21 (29%)
		leucine-rich repeat	616..637	CDD:275380	6/22 (27%)
		leucine-rich repeat	638..662	CDD:275380	11/23 (48%)
		leucine-rich repeat	663..684	CDD:275380	8/20 (40%)
		leucine-rich repeat	685..708	CDD:275380	5/22 (23%)
		leucine-rich repeat	709..728	CDD:275380	5/25 (20%)
		LRR_8	883..943	CDD:290566	14/59 (24%)
		leucine-rich repeat	885..908	CDD:275380	7/22 (32%)
		leucine-rich repeat	909..932	CDD:275380	4/22 (18%)
		LRR_8	932..990	CDD:290566	13/63 (21%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	38/150 (25%)
Tlr11	NP_001138251.2	leucine-rich repeat	111..133	CDD:275380	7/25 (28%)
		LRR_RI	<179..427	CDD:238064	82/301 (27%)
		leucine-rich repeat	224..246	CDD:275380	6/21 (29%)
		leucine-rich repeat	248..270	CDD:275380	9/35 (26%)
		LRR_8	270..329	CDD:290566	17/69 (25%)
		leucine-rich repeat	271..293	CDD:275380	5/32 (16%)
		leucine-rich repeat	294..318	CDD:275380	8/23 (35%)
		LRR_8	319..378	CDD:290566	24/80 (30%)
		leucine-rich repeat	319..342	CDD:275380	7/22 (32%)
		leucine-rich repeat	343..367	CDD:275380	12/45 (27%)
		LRR_8	366..426	CDD:290566	24/62 (39%)
		leucine-rich repeat	368..391	CDD:275380	6/22 (27%)
		leucine-rich repeat	392..415	CDD:275380	11/23 (48%)
		LRR_8	416..471	CDD:290566	15/61 (25%)
		leucine-rich repeat	416..437	CDD:275380	8/20 (40%)
		leucine-rich repeat	440..463	CDD:275380	6/29 (21%)
		leucine-rich repeat	533..583	CDD:275380	15/85 (18%)
		leucine-rich repeat	584..612	CDD:275380	11/46 (24%)
		leucine-rich repeat	613..633	CDD:275380	5/19 (26%)
		TIR_2	781..>861	CDD:290400	20/79 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820