DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Lgr6

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	150/632 - (23%)
Similarity:	239/632 - (37%)	Gaps:	183/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 STSCS--------LDLE----YLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGL 324
            |..||        .||:    |||:|.|:...|....|..||.|..|.::.|.:|.|..:|.|||
  Rat    49 SADCSELGLSEVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPRQAFSGL 113

  Fly   325 KNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITST 389
            .:|:||.|.||::..:|.|...|... :|.:.|..|.||::..:.|..|..|:.|.|..|.:|.
  Rat   114 HSLKILMLQSNQLRGIPAEALWELPS-LQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE- 176

  Fly   390 WIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLL 454
             |.......|..|..:.|:.|::..:....|.:|.:|.:|:|.:|:::::...:|..::||.||.
  Rat   177 -IPVRALNNLPALQAMTLALNRIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLD 240

  Fly   455 LSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNM 518
            |::|:|:..                         |.|.|....||:|..:.|.:|.:| .|....
  Rat   241 LNYNELQEF-------------------------PVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 280

  Fly   519 RHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDL---PNLQILNLARNRIA 580
            ..|:|:...:|.|..:..|||:.|..|:.|.|.|    ...:..|.||   .:|:||.|.|..|.
  Rat   281 PLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNG----ATDIQEFPDLKGTTSLEILTLTRAGIR 341

  Fly   581 VVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHK 645
            ::..                       |:...:|.|..|.:|.|::|.....|....|:.:.|..
  Rat   342 LLPA-----------------------GMCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLQH 383

  Fly   646 NRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLT 710
            ||:..:    |.|          :|:||         :|::.|.|:.|.|..:.|:.|....:|.
  Rat   384 NRIWEI----GAD----------TFSQL---------SSLQALDLSWNAIRAIHPEAFSTLRSLV 425

  Fly   711 RVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLE 775
            ::||..||:|||.:..|        ..|....:.||          |......:...:|::..||
  Rat   426 KLDLTDNQLTTLPLAGL--------GGLMHLKLKGN----------LALSQAFSKDSFPKLRILE 472

  Fly   776 TIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWST 840
            ..|         ||                       .||.:..|                   .
  Rat   473 VPY---------AY-----------------------QCCAYGLC-------------------A 486

  Fly   841 NIVECSG--------AAYSEMPRR------------VPMDTSELYID 867
            |..:.||        |...|.|:|            ..:|..||.::
  Rat   487 NFFKTSGQWQAEDFHAEEEEAPKRPLGLLAGQAENHYDLDLDELQME 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	3/13 (23%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	60/193 (31%)
		leucine-rich repeat	279..302	CDD:275380	9/26 (35%)
		LRR_8	301..386	CDD:290566	30/84 (36%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	95/382 (25%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..401	CDD:275380	7/24 (29%)
		LRR_RI	<401..626	CDD:238064	54/228 (24%)
		leucine-rich repeat	402..425	CDD:275380	5/22 (23%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	6/22 (27%)
		leucine-rich repeat	474..497	CDD:275380	3/22 (14%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..566	CDD:275380	5/20 (25%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	1/21 (5%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	6/23 (26%)
		leucine-rich repeat	663..684	CDD:275380	3/20 (15%)
		leucine-rich repeat	685..708	CDD:275380	6/22 (27%)
		leucine-rich repeat	709..728	CDD:275380	8/18 (44%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470	5/18 (28%)
		LRR_RI	<70..248	CDD:238064	58/180 (32%)
		leucine-rich repeat	70..91	CDD:275380	8/20 (40%)
		LRR_8	92..150	CDD:290566	21/58 (36%)
		leucine-rich repeat	92..115	CDD:275380	9/22 (41%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		LRR_8	138..198	CDD:290566	17/62 (27%)
		leucine-rich repeat	140..163	CDD:275380	7/22 (32%)
		leucine-rich repeat	164..187	CDD:275380	7/24 (29%)
		LRR_8	186..246	CDD:290566	16/59 (27%)
		leucine-rich repeat	188..211	CDD:275380	5/22 (23%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..258	CDD:275380	9/46 (20%)
		LRR_RI	253..>442	CDD:238064	61/238 (26%)
		LRR_8	258..314	CDD:290566	18/55 (33%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		leucine-rich repeat	283..304	CDD:275380	7/20 (35%)
		LRR_8	305..364	CDD:290566	19/85 (22%)
		leucine-rich repeat	330..344	CDD:275378	6/13 (46%)
		leucine-rich repeat	354..375	CDD:275380	6/20 (30%)
		LRR_8	375..434	CDD:290566	20/81 (25%)
		leucine-rich repeat	376..399	CDD:275380	9/45 (20%)
		leucine-rich repeat	400..421	CDD:275380	6/20 (30%)
		leucine-rich repeat	424..444	CDD:275380	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010