DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Tollo

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster


Alignment Length:1388 Identity:553/1388 - (39%)
Similarity:819/1388 - (59%) Gaps:163/1388 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 PLTAGAGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILC 127
            |:...|.....||.|||:|.:   :|..:.:|.|.|:|||:|||.:.||||||..::|:.|.:.|
  Fly    18 PIFGAALSKTVLYQAPDECRW---SGGGEHDITLVCHLRTINSELENTNFSVIQPQNTVRLRLEC 79

  Fly   128 NDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIE 192
            ||.:..:|.|...||..||.|:.|:|:|||||.|......||::|||||:||||..|..::.|:.
  Fly    80 NDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMA 144

  Fly   193 ADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTE 257
            :::|...|:|||||||.||||.:||.:.|.|..|..||.|.|::||::...|             
  Fly   145 SNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYF------------- 196

  Fly   258 STSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALS 322
                  ||..||..:..|...|:.||:|.|..|.||......|.||..|::..|.:|.:||:|..
  Fly   197 ------SASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFE 255

  Fly   323 GLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQIT 387
            ||.:|::::||:|::.:||.||||| .|.:||:||:||||:||.|.:|..|.:|..|||:.|::.
  Fly   256 GLLSLRVVDLSANRLTSLPPELFAE-TKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELN 319

  Fly   388 STWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHT 452
            |.||:..|||||.||::|:||.||:::||..||..|.:||||.|..|.::.:....||.:.||||
  Fly   320 SQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHT 384

  Fly   453 LLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRN 517
            |:||.|::..::...|.||..|.:||||.|.:..:...:..|||.||||:||.|:|:.||.||.:
  Fly   385 LILSRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAH 449

  Fly   518 MRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVV 582
            ::.|:|:|:|||||:.:|:::...|.:|||||:..|.|.:|....|..:.:||||||::|::..:
  Fly   450 VQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSI 514

  Fly   583 EPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNR 647
            |.|:.:..|.:||:|||||:|..|.|||:.:|:|:|||||.||||.|||.|:|..|||||:..||
  Fly   515 EAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANR 579

  Fly   648 LSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRV 712
            ::.|.|.|.::|||.|.|.|.|:|.|..|..||||||:|:|:||||.|:.:.|.||..|.|||||
  Fly   580 ITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRV 644

  Fly   713 DLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETI 777
            ||..|::|||:..:||:.|:.|.|.:||||||.|.:.||||:|||||:|. .||..|::|||:.|
  Fly   645 DLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNR-ESRTQPQLMDLDQI 708

  Fly   778 YCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNI 842
            :|:|...|..:::.||||:...|||.|.:||||:||||:|.||||:|.||..|:|:|||:|::|:
  Fly   709 HCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNV 773

  Fly   843 VECSGAAYSE-MPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGL 906
            |:||.|:|.: :|..:|||:::||:|||||.||..|:|:|||.|.||:.|:|.:..::|.||.||
  Fly   774 VDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGL 838

  Fly   907 KRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFE 971
            ..|.:|.|:.|.:.:|.||||..|:||:|||||.|.||:|...:|..|..|::||||.|.:..|.
  Fly   839 LELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFA 903

  Fly   972 VWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSC--IYNNATS--VLREK 1032
            ||....: ||.|:.||.|.|:|.|.::.:.|:|:.: .|.::|..::.|  |..|:|.  |:...
  Fly   904 VWNFLPS-YLNELRLASNPWTCSCEFIDKLRDYINR-HEYVVDKLKMKCDVISGNSTQQMVIYPG 966

  Fly  1033 NG-------TKC--TLRDGVAHYMHTNEIEG---------------------LLPLLLVATCAFV 1067
            :|       .:|  ||..|:.:..:..|..|                     .:|:|:....||:
  Fly   967 SGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAILTAFI 1031

  Fly  1068 AFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILA 1132
            .....|..:|.:|.|:::|.||...:..| |.:.:.||:.::|:..||:.:||.:||.|||:.||
  Fly  1032 FVMICISLVFIFRQEMRVWCHSRFGVRLF-YNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELA 1095

  Fly  1133 QTLE-NDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELV 1196
            ..|| .:..|:||||.||..:..|:.:.:::|.:|:::.::|:|:||:.:||.|||:|||...::
  Fly  1096 PMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVL 1160

  Fly  1197 K-RRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVSG 1260
            : ||:|::.|:.|::||:::|.|:|.||:|:|.::|.||.||||||.|||               
  Fly  1161 RDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQWGDKLFWQKLRFALP--------------- 1210

  Fly  1261 CLSGRTPSVNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASA 1325
                     ::.::.....||....:|...|.|                                
  Fly  1211 ---------DVSSSQRSNVAGQSCHVPINHASY-------------------------------- 1234

  Fly  1326 AAAACKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANR---RSQHEYAVPSYLP------- 1380
                                           |.|||.||...   .|.|.:.....||       
  Fly  1235 -------------------------------HHHHHVHQQAMPLPHSVHHHQQQFMLPPPPQQPG 1268

  Fly  1381 --SAAPAYDSVDYAKQQIRNNAN 1401
              ...|:.......:||||.|.|
  Fly  1269 SFRRQPSLHQQQQQQQQIRGNNN 1291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 11/22 (50%)
LRR_8 171..236 CDD:290566 33/64 (52%)
leucine-rich repeat 172..201 CDD:275380 12/28 (43%)
leucine-rich repeat 202..278 CDD:275380 28/75 (37%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 85/189 (45%)
leucine-rich repeat 279..302 CDD:275380 9/22 (41%)
LRR_8 301..386 CDD:290566 40/84 (48%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 11/22 (50%)
LRR 350..729 CDD:227223 185/378 (49%)
leucine-rich repeat 352..375 CDD:275380 13/22 (59%)
leucine-rich repeat 376..401 CDD:275380 13/24 (54%)
LRR_RI <401..626 CDD:238064 101/224 (45%)
leucine-rich repeat 402..425 CDD:275380 11/22 (50%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 10/22 (45%)
leucine-rich repeat 474..497 CDD:275380 8/22 (36%)
leucine-rich repeat 498..518 CDD:275380 12/19 (63%)
leucine-rich repeat 521..544 CDD:275380 10/22 (45%)
leucine-rich repeat 545..566 CDD:275380 9/20 (45%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 12/21 (57%)
leucine-rich repeat 616..637 CDD:275380 15/20 (75%)
leucine-rich repeat 638..662 CDD:275380 12/23 (52%)
leucine-rich repeat 663..684 CDD:275380 11/20 (55%)
leucine-rich repeat 685..708 CDD:275380 11/22 (50%)
leucine-rich repeat 709..728 CDD:275380 10/18 (56%)
LRR_8 883..943 CDD:290566 29/59 (49%)
leucine-rich repeat 885..908 CDD:275380 10/22 (45%)
leucine-rich repeat 909..932 CDD:275380 10/22 (45%)
LRR_8 932..990 CDD:290566 27/57 (47%)
leucine-rich repeat 933..956 CDD:275380 12/22 (55%)
TIR 1114..1247 CDD:214587 61/134 (46%)
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 88/215 (41%)
leucine-rich repeat 100..123 CDD:275380 11/22 (50%)
leucine-rich repeat 124..144 CDD:275380 11/19 (58%)
LRR_8 152..222 CDD:290566 34/88 (39%)
leucine-rich repeat 154..177 CDD:275380 15/22 (68%)
leucine-rich repeat 178..201 CDD:275380 10/41 (24%)
LRR 210..656 CDD:227223 214/446 (48%)
leucine-rich repeat 212..235 CDD:275380 9/22 (41%)
leucine-rich repeat 236..259 CDD:275380 9/22 (41%)
leucine-rich repeat 260..283 CDD:275380 11/23 (48%)
LRR_RI 276..558 CDD:238064 133/282 (47%)
leucine-rich repeat 284..307 CDD:275380 13/22 (59%)
leucine-rich repeat 308..333 CDD:275380 13/24 (54%)
leucine-rich repeat 334..357 CDD:275380 11/22 (50%)
leucine-rich repeat 358..381 CDD:275380 8/22 (36%)
leucine-rich repeat 382..405 CDD:275380 10/22 (45%)
leucine-rich repeat 406..429 CDD:275380 8/22 (36%)
leucine-rich repeat 430..452 CDD:275380 12/21 (57%)
leucine-rich repeat 453..500 CDD:275380 19/46 (41%)
leucine-rich repeat 501..521 CDD:275380 9/19 (47%)
leucine-rich repeat 525..547 CDD:275380 12/21 (57%)
leucine-rich repeat 548..573 CDD:275380 17/24 (71%)
leucine-rich repeat 604..640 CDD:275380 19/35 (54%)
leucine-rich repeat 641..688 CDD:275380 26/46 (57%)
leucine-rich repeat 689..816 CDD:275380 67/127 (53%)
LRR_8 815..875 CDD:290566 29/59 (49%)
leucine-rich repeat 817..864 CDD:275380 20/46 (43%)
LRR_8 864..921 CDD:290566 27/57 (47%)
leucine-rich repeat 865..888 CDD:275380 12/22 (55%)
leucine-rich repeat 889..910 CDD:275380 9/20 (45%)
TIR 1076..1211 CDD:214587 61/158 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453673
Domainoid 1 1.000 44 1.000 Domainoid score I4673
eggNOG 1 0.900 - - E2759_KOG4641
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 219 1.000 Inparanoid score I3549
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG28754
OrthoDB 1 1.010 - - D12592at6656
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 1 0.900 - - OOG6_104126
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R17065
SonicParanoid 1 1.000 - - X221
1110.740

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