DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and kek6

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	175/892 - (19%)
Similarity:	282/892 - (31%)	Gaps:	331/892 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 ACDCEMTCPTNCTCFHDQTWST--NIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSF-- 879
            |.|..::|.:||||    .|:.  ....||....:.:|..:..:...|.::.|:...|....|
  Fly    31 ADDWSLSCASNCTC----KWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFST 91

  Fly   880 LGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIA 944
            ||..||..:|...|.|.:|:..:|..||.|:.:.|.||.:..|:.:.|...:.||.|||..|.:.
  Fly    92 LGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLK 156

  Fly   945 SIANGSFQM------------------------LRKLEVLRLDGNRLMHFE--VWQLSANPYLVE 983
            .:|...|.:                        |..||.|.|..|.|....  |:|..||  |..
  Fly   157 RLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMAN--LKT 219

  Fly   984 ISLADNQWSCECGYLARFRNYL-------------GQSSEK-----IIDASRVSC-----IYNN- 1024
            :||.:|.|.|.| .|.:||.:.             |..::|     .:|.....|     |:||
  Fly   220 LSLEENPWQCNC-KLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNE 283

  Fly  1025 ---------------------ATSVLREKNGT--------------------------------- 1035
                                 ...|..|.||.
  Fly   284 EVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDA 348

  Fly  1036 ---KCTLRDGVAHYMHTNEI--EGLLPLLLVATCAFVAFFGLIFGLF---------------C-- 1078
               .||..:.:........|  ..::..:|..|.....:||||.|:|               |
  Fly   349 GTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKR 413

  Fly  1079 ----YRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDI 1139
                :||..|....|:   ::|..:..:.:|.......||...:|.:.::       ..::..:.
  Fly   414 TTRQHRHANKAGVKSS---VSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQ-------PTSIGMNK 468

  Fly  1140 GYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVF 1204
            |....:.:..:.|:         |.||.:...:                      ||:::.:...
  Fly   469 GDSAGMGFNQIEIH---------AVESHRHGSM----------------------LVQQQPQQQQ 502

  Fly  1205 ILYGDLPQRDIDMDMRHYL---RTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRT 1266
            :..|.        .||..|   :.|||                               |.:|..|
  Fly   503 VAGGG--------GMRQQLMQVKDSTC-------------------------------GMMSVPT 528

  Fly  1267 PSVNMYATSHEYQAG-----NGGVIPPPSARYADC------GSNNY--ATINECAAAGGGRGYKP 1318
             |:..:|.||..|..     |.||.|||....::.      |.|.:  .::.:....|......|
  Fly   529 -SMAGHAHSHPAQISEEFPLNVGVFPPPPEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADLNMYP 592

  Fly  1319 ----IP------TSASAAAAAC---KFNTMNQLSKKQ---QRDLSVAGMAKTLEHQHHHNHQAN- 1366
                ||      ..:.|.|.|.   :|.|:.:.:.::   ::|.|:  ..:..:||..|.||..
  Fly   593 DLLNIPKRMQDVQESGAGAVAVPEGQFATLPRHTARRGILKKDTSL--QQQQQQHQQQHQHQQQQ 655

  Fly  1367 -----RRSQHEYAVPSYLPSAAPAYDS-VDYAKQQIRNNANCECVNLGTAKRAAGKNPASGLPSS 1425
                 ::.||:.....:.||....:|. |.|              ||    .|:|.:|..   |.
  Fly   656 QQQQIQQQQHQQLQQQHQPSGLYTHDEIVTY--------------NL----EASGYDPHQ---SG 699

  Fly  1426 FSSNFV----PPGGASYNCKKSC---------SCIGDDELLCSCGGGGGIGVNLLESGTQS---S 1474
            :.||.:    ||...:......|         |||.:              .....|..||   .
  Fly   700 YHSNAMELPPPPPPPAVTAVVQCHHPSPNNCASCINN--------------APPPPSACQSPPVE 750

  Fly  1475 VTMSSSSNNSRQPELTHYE--------------SNLSLNDDEDEDHD 1507
            ||.....::|..|:   |:              |||||:|:|..:::
  Fly   751 VTPMRPLDSSAYPK---YDNMGRRITASGGLGGSNLSLHDEERYENE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	21/59 (36%)
		leucine-rich repeat	885..908	CDD:275380	7/22 (32%)
		leucine-rich repeat	909..932	CDD:275380	6/22 (27%)
		LRR_8	932..990	CDD:290566	22/83 (27%)
		leucine-rich repeat	933..956	CDD:275380	9/46 (20%)
		TIR	1114..1247	CDD:214587	16/135 (12%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	21/58 (36%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	8/41 (20%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..216	CDD:275380	9/46 (20%)
		LRRCT	225..274	CDD:214507	10/49 (20%)
		Ig	295..367	CDD:143165	6/71 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840