DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Tl

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	1356	Identity:	313/1356 - (23%)
Similarity:	508/1356 - (37%)	Gaps:	424/1356 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DDCHFMPAAGLDQ-----PEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCN-------DEI 131
            |.|..|...||.|     .|..:.|   ..|:|..|...::.|.::   :.|:||       .::
  Fly    32 DACSEMSIDGLCQCAPIMSEYEIIC---PANAENPTFRLTIQPKDY---VQIMCNLTDTTDYQQL 90

  Fly   132 MAKSRL--------------------EAQSFAHLVRLQQLSIQYCKLG-RLGRQVLD---GLEQL 172
            ..|.|:                    ....:..:|....|..:...|| .:.||.||   ||::.
  Fly    91 PKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRF 155

  Fly   173 RNLTLR-TH---NILWPALNF----------EIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTL 223
            |..|.| ||   |:|....|.          |:.:..|.....||.::..||.:..:|..||..:
  Fly   156 RFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKM 220

  Fly   224 SELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHND 288
            .:|..||:..|:|.::        :|....|:|....
  Fly   221 PKLKQLNLWSNQLHNL--------TKHDFEGATSVLG---------------------------- 249

  Fly   289 FVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQ 353
                             :.:::|||..:.....:.|.|:..:|||:|...:||..|| :..|.:.
  Fly   250 -----------------IDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLF-DHNKHLN 296

  Fly   354 EVYLQNNSI--SVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLE 416
            ||.|.||.:  :.|..:||:|                                           :
  Fly   297 EVRLMNNRVPLATLPSRLFAN-------------------------------------------Q 318

  Fly   417 PEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDN 481
            ||       ||||.||                                         ..|.||..
  Fly   319 PE-------LQILRLR-----------------------------------------AELQSLPG 335

  Fly   482 NALIGVHPDAFRNCSALQDLNLNGNQLKTVPLA-LRNMRHLRTVDLGENMITVMEDSAFKGLGNL 545
                    |.|.:.:.:.:::|..|.|||:|.. |.:..:|.::||..|.:|.:.||.|....||
  Fly   336 --------DLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNL 392

  Fly   546 YGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELN------ 604
            ..|||..|.|..|:...|.:|.||..|.::|||:..::..||..|:.::.:.||.|:::
  Fly   393 TDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLL 457

  Fly   605 ------DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKL 663
                  .||..|..|..||.||:.:|.: .|.|.      .|    ||.:            |:|
  Fly   458 DIMLQTQINSPFGYMHGLLTLNLRNNSI-IFVYN------DW----KNTM------------LQL 499

  Fly   664 QTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDL---------YANQI 719
            :.||:|:|.:..:|..      :|.||:.|.:     ...|....:.|:.|         |.|.:
  Fly   500 RELDLSYNNISSLGYE------DLAFLSQNRL-----HVNMTHNKIRRIALPEDVHLGEGYNNNL 553

  Fly   720 TTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDW-LQKINHITSRQYPRIMDLET--IYCKL 781
            ..:|:..                   ||..|||.|.| :|.:..:...||.|...|.|  :.|..
  Fly   554 VHVDLND-------------------NPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQ 599

  Fly   782 LNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTW-STNIVEC 845
            .|..|..  |:.:.||:..:|.           .:|.....|..||..|.| |.:|: ...::.|
  Fly   600 PNVLEGT--PVRQIEPQTLICP-----------LDFSDDPRERKCPRGCNC-HVRTYDKALVINC 650

  Fly   846 SGAAYSEMPRRVP-----MDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSG 905
            .....:.:| |:|     |...||:::.|..:.|..             ||.           .|
  Fly   651 HSGNLTHVP-RLPNLHKNMQLMELHLENNTLLRLPS-------------ANT-----------PG 690

  Fly   906 LKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHF 970
            .:.:..|||..|::.|::.::...  ||..|.:..|.:        |||....:..|  ||.|.:
  Fly   691 YESVTSLHLAGNNLTSIDVDQLPT--NLTHLDISWNHL--------QMLNATVLGFL--NRTMKW 743

  Fly   971 EVWQLSANPYLVEISLADNQWSCECGY--LARFRNYLGQSSEKIIDASRVSCIYNNA---TSVLR 1030
            ...:||.||           |.|:|..  |..|..   .:.|:|.|.:.:.|:  ||   |.::.
  Fly   744 RSVKLSGNP-----------WMCDCTAKPLLLFTQ---DNFERIGDRNEMMCV--NAEMPTRMVE 792

  Fly  1031 EKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGL-----FCYRHELKIWAHST 1090
            ......|....||                .:|....:|..||:.|.     :.::.|:|||.::.
  Fly   793 LSTNDICPAEKGV----------------FIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAH 841

  Fly  1091 NCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIG---YRLCLHYRDVNI 1152
            |.|:.|..:     :.|||::..||:.:||.:|:.|:...|...||:  |   ::||:|.||..:
  Fly   842 NLLLWFVTE-----EDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEH--GPQKFQLCVHERDWLV 899

  Fly  1153 NAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEY----KSALHELVKRRKRVVFILYGDLPQ- 1212
            ..:|.:.::.:...:::.::|||:||:.:||:|.|:    :|||:|   .|.|::.|:|.|:..
  Fly   900 GGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNE---GRSRIIVIIYSDIGDV 961

  Fly  1213 RDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGN-NNKRVVSGCLSGRT--------PS 1268
            ..:|.:::.||:.:|.::|.|..||.|||.|||.....|| .|..::...|.|.|        ||
  Fly   962 EKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPS 1026

  Fly  1269 --------VNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGY 1316
                    ....||.:...|...||.|..:...|: |.|....:........|.|:
  Fly  1027 PVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIAN-GKNGLTNLYTPNGKSHGNGH 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	9/26 (35%)
		LRR_8	171..236	CDD:290566	21/78 (27%)
		leucine-rich repeat	172..201	CDD:275380	10/42 (24%)
		leucine-rich repeat	202..278	CDD:275380	15/75 (20%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	31/191 (16%)
		leucine-rich repeat	279..302	CDD:275380	0/22 (0%)
		LRR_8	301..386	CDD:290566	23/86 (27%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	91/402 (23%)
		leucine-rich repeat	352..375	CDD:275380	9/24 (38%)
		leucine-rich repeat	376..401	CDD:275380	0/24 (0%)
		LRR_RI	<401..626	CDD:238064	59/237 (25%)
		leucine-rich repeat	402..425	CDD:275380	2/22 (9%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	0/22 (0%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..566	CDD:275380	8/20 (40%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	7/33 (21%)
		leucine-rich repeat	616..637	CDD:275380	7/20 (35%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	6/20 (30%)
		leucine-rich repeat	685..708	CDD:275380	5/22 (23%)
		leucine-rich repeat	709..728	CDD:275380	5/27 (19%)
		LRR_8	883..943	CDD:290566	12/59 (20%)
		leucine-rich repeat	885..908	CDD:275380	3/22 (14%)
		leucine-rich repeat	909..932	CDD:275380	5/22 (23%)
		LRR_8	932..990	CDD:290566	15/57 (26%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	48/140 (34%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	14/58 (24%)
		leucine-rich repeat	176..198	CDD:275380	2/21 (10%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		LRR_RI	216..542	CDD:238064	111/512 (22%)
		LRR_8	221..281	CDD:290566	17/112 (15%)
		leucine-rich repeat	223..270	CDD:275380	12/99 (12%)
		leucine-rich repeat	271..294	CDD:275380	8/23 (35%)
		leucine-rich repeat	295..320	CDD:275380	9/67 (13%)
		leucine-rich repeat	321..343	CDD:275380	11/70 (16%)
		LRR_8	342..402	CDD:290566	21/59 (36%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		leucine-rich repeat	368..391	CDD:275380	8/22 (36%)
		LRR_8	390..450	CDD:290566	22/59 (37%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..439	CDD:275380	8/22 (36%)
		leucine-rich repeat	440..474	CDD:275380	7/33 (21%)
		leucine-rich repeat	475..498	CDD:275380	10/45 (22%)
		LRR_8	477..534	CDD:290566	20/90 (22%)
		leucine-rich repeat	499..520	CDD:275380	7/26 (27%)
		leucine-rich repeat	523..552	CDD:275380	5/33 (15%)
		LRRCT	561..619	CDD:214507	19/59 (32%)
		LRRNT	631..667	CDD:214470	10/37 (27%)
		leucine-rich repeat	664..693	CDD:275380	8/52 (15%)
		LRR_8	669..726	CDD:290566	16/82 (20%)
		leucine-rich repeat	694..715	CDD:275380	5/22 (23%)
		leucine-rich repeat	716..737	CDD:275380	6/28 (21%)
		LRRCT	751..800	CDD:214507	14/64 (22%)
		TIR	858..996	CDD:214587	48/142 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453824
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8062
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	8	7.700