DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and CG5810

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_650952.2	Gene:	CG5810 / 42513	FlyBaseID:	FBgn0038866	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	463	Identity:	108/463 - (23%)
Similarity:	203/463 - (43%)	Gaps:	99/463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAF---SVT--- 199
            ::.:.:.:..::...|:..:|....:|.|:...|...   |:.:|:.:    |.|:   :||
  Fly     5 NYLNYILIAVIAFATCESQKLEEIAIDSLDCRENTCT---NLKYPSAS----AVAYFSENVTKHL 62

  Fly   200 RRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTES 264
            |:.|.|.|.|:::.:||..||..|.:|...::.|..||.:..:.| |.:|     :.:..:...:
  Fly    63 RKYETLVLHSSDLANLPRKIFLNLPQLVEFHVLECELQQIESVCF-DGAK-----NLKRLNFGGN 121

  Fly   265 AKKSSSSST-SCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQ 328
            |.:...|:| ..:..||.|::|.|....||...|..|:.|:.::::||.:..::....|.|.:|:
  Fly   122 ALRVLDSNTFELATQLEELNLSDNQLEDLPTTIFRPLKNLQKINLSNNRLITLSQHIFSQLGSLK 186

  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLD--------QLQALDLS--M 383
            .:|:.||::|.||.|||.:|.|.:.|...|:|.:..:...:|..:|        ||:.|.||  :
  Fly   187 SINVDSNQLVELPGELFRDQRKHLSEFSAQSNQLVRIPFNIFREIDHLSLSFNPQLRRLHLSAKI 251

  Fly   384 NQITSTWIDKNTFVGLIRLVLLNLSHN-KLTKL---EPEIFSDLY--------------TLQILN 430
            |::.:|..|..:.....|::.:.|..| ||.:|   :|:....||              ..::::
  Fly   252 NELEATNCDLESVELDGRVIGVQLEANPKLHELKISQPQDLEHLYLANTNLYRLDFLSKASKLVD 316

  Fly   431 LRHNQLENIA--------------ADTFAPMNNLHTLLLSHNK-LKYLDAYALNGLYVLSLLSLD 480
            |....:.|:|              :.|:..:.:.|..:|.|.| |.||:.....|..:. :..||
  Fly   317 LDVTDIVNLADLPKITSAKGLERLSFTYDNLTSNHMDMLPHLKDLNYLEISHEKGKEIF-IKDLD 380

  Fly   481 NNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNL 545
            .:..:   .:|..||..|.||                   |..|:|.:: .|::||
  Fly   381 EDFFV---EEAELNCGQLADL-------------------LEFVELPKD-TTILED--------- 413

  Fly   546 YGLRLIGN 553
               ||:|:
  Fly   414 ---RLVGD 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		LRR_8	171..236	CDD:290566	19/70 (27%)
		leucine-rich repeat	172..201	CDD:275380	7/34 (21%)
		leucine-rich repeat	202..278	CDD:275380	19/76 (25%)
		leucine-rich repeat	229..249	CDD:275380	5/19 (26%)
		LRR_RI	278..468	CDD:238064	59/232 (25%)
		leucine-rich repeat	279..302	CDD:275380	9/22 (41%)
		LRR_8	301..386	CDD:290566	28/94 (30%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	11/22 (50%)
		LRR	350..729	CDD:227223	52/247 (21%)
		leucine-rich repeat	352..375	CDD:275380	5/30 (17%)
		leucine-rich repeat	376..401	CDD:275380	7/26 (27%)
		LRR_RI	<401..626	CDD:238064	38/186 (20%)
		leucine-rich repeat	402..425	CDD:275380	8/40 (20%)
		leucine-rich repeat	426..449	CDD:275380	4/36 (11%)
		leucine-rich repeat	450..473	CDD:275380	8/23 (35%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	3/19 (16%)
		leucine-rich repeat	521..544	CDD:275380	6/22 (27%)
		leucine-rich repeat	545..566	CDD:275380	3/9 (33%)
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CG5810	NP_650952.2	leucine-rich repeat	65..88	CDD:275380	9/22 (41%)
		LRR_8	87..147	CDD:290566	15/65 (23%)
		leucine-rich repeat	89..112	CDD:275380	7/28 (25%)
		leucine-rich repeat	113..136	CDD:275380	3/22 (14%)
		LRR_8	135..195	CDD:290566	18/59 (31%)
		LRR_4	135..175	CDD:289563	12/39 (31%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	5/22 (23%)
		leucine-rich repeat	185..209	CDD:275380	11/23 (48%)
		leucine-rich repeat	210..231	CDD:275380	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930