DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and CG18249

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	142/573 - (24%)
Similarity:	220/573 - (38%)	Gaps:	176/573 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 ADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTE 257
            :||.:|.....|.:||:    |.||: ||:||:......:...|| :.||..|:.|::
  Fly    17 SDALAVYDASGRFNLSA----SCPDS-FCSLSDRPVAYSATPALQ-LRELHLRNCSRQ------- 68

  Fly   258 STSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALS 322
                         |.|...|.|            .|.        ||.|.:.|.....|:.::|.
  Fly    69 -------------SITWLVLQL------------TPG--------LRTLVIRNCATYHISKESLR 100

  Fly   323 GLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQIT 387
            .::||..|.                         :|..|:.||..|:|:.:.:|:.|.||.|.|.
  Fly   101 PVENLTSLQ-------------------------MQGTSLGVLRDQIFNAVPRLEILQLSQNFIH 140

  Fly   388 STWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHT 452
            :..:  ..|.||.:|.||.|..|.:.::.......|..|..|:|..|:|..:..:.||....|.|
  Fly   141 TVHV--AAFQGLSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQT 203

  Fly   453 LLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRN 517
            |||:.|.|:.|....|..|..|.||.|.:.|                       :|:.:.|.|.|
  Fly   204 LLLNGNPLRILMPDVLGSLPNLRLLDLGHAA-----------------------ELEVMTLNLTN 245

  Fly   518 MRHLRTVDLGENMITVMEDSAFKGL---GNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRI 579
            :::|           |:|.|:...|   |....|: .||          .:|.:||:.|
  Fly   246 VQNL-----------VLEGSSLSSLVINGGFIKLQ-AGN----------NELNHLQVGN------ 282

  Fly   580 AVVEPGAFEMTSSIQAVRLDGNEL--NDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLD 642
                      .||:..:.|.||.|  ||...|...|    |                  .||.||
  Fly   283 ----------KSSVIEMDLHGNLLNGNDTAALLRGM----W------------------NLQRLD 315

  Fly   643 LHKNRLSSL-SNRFGLDS----EL----KLQTLDVSFNQLQRIGPSS--IPNSIELLFLNDNLIT 696
            |.|||:.:| .:..|||:    ||    .|:.|:::.|||.|:.|.|  :.:.:..|.|:.||:.
  Fly   316 LSKNRIEALPQHGSGLDASGTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHNLML 380

  Fly   697 TVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFT 749
            |:|.......:.|..:.:..|::.|::.:.|.    .||..|.|..:..||::
  Fly   381 TLDVAILRSLSVLKGLYVEGNRLNTINYQKLH----EEHPDLSELGLHDNPWS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	13/42 (31%)
		leucine-rich repeat	172..201	CDD:275380	3/7 (43%)
		leucine-rich repeat	202..278	CDD:275380	18/75 (24%)
		leucine-rich repeat	229..249	CDD:275380	5/19 (26%)
		LRR_RI	278..468	CDD:238064	47/189 (25%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		LRR_8	301..386	CDD:290566	20/84 (24%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR	350..729	CDD:227223	103/394 (26%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	9/24 (38%)
		LRR_RI	<401..626	CDD:238064	56/229 (24%)
		leucine-rich repeat	402..425	CDD:275380	6/22 (27%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	10/22 (45%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	3/19 (16%)
		leucine-rich repeat	521..544	CDD:275380	5/25 (20%)
		leucine-rich repeat	545..566	CDD:275380	3/20 (15%)
		leucine-rich repeat	569..592	CDD:275380	3/22 (14%)
		leucine-rich repeat	593..615	CDD:275380	8/23 (35%)
		leucine-rich repeat	616..637	CDD:275380	1/20 (5%)
		leucine-rich repeat	638..662	CDD:275380	14/32 (44%)
		leucine-rich repeat	663..684	CDD:275380	8/22 (36%)
		leucine-rich repeat	685..708	CDD:275380	6/22 (27%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	8/54 (15%)
		LRR_8	104..163	CDD:290566	23/85 (27%)
		leucine-rich repeat	105..128	CDD:275380	8/47 (17%)
		LRR_RI	107..438	CDD:238064	110/437 (25%)
		leucine-rich repeat	129..152	CDD:275380	9/24 (38%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		LRR_8	176..232	CDD:290566	21/55 (38%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		leucine-rich repeat	201..224	CDD:275380	10/22 (45%)
		leucine-rich repeat	225..258	CDD:275380	13/66 (20%)
		leucine-rich repeat	259..310	CDD:275380	20/99 (20%)
		leucine-rich repeat	311..344	CDD:275380	14/32 (44%)
		LRR_8	343..403	CDD:290566	16/59 (27%)
		leucine-rich repeat	345..368	CDD:275380	8/22 (36%)
		leucine-rich repeat	369..390	CDD:275380	6/20 (30%)
		leucine-rich repeat	393..417	CDD:275380	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840