DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and CG7800

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	141/588 - (23%)
Similarity:	235/588 - (39%)	Gaps:	138/588 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 IFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSC-------- 275
            |...|:.:|||...:  |:|     :.:.|.....|.:.:.|..::.|.:.....||
  Fly     5 IIALLASVSALGRPD--LED-----YCNDSYCHLLGRSRTFSDKKATKLTEFHMDSCEKKVLKLM 62

  Fly   276 ----SLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK 336
                :|:||..|  ..||.:   |....|..|..|.:....:..:.|:..|...|::||.|..|.
  Fly    63 PNLRTLELENCD--SPDFTM---NDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNN 122

  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIR 401
            |..|..|.|...|: :..:.|..|.|..|...:|.||.:|..||||.|:|.:  :.:|.|.|:.:
  Fly   123 ITRLSNECFKGLAQ-LWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIET--LHENIFTGVPK 184

  Fly   402 LVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNL-----HTLLLSHNKLK 461
            |.:|.|:.|.||.:.|.....|..|::|::          ....|:.:|     |||:|.::.::
  Fly   185 LEMLLLNGNPLTWIAPTSLKSLSNLRLLDM----------SNCGPLPDLSLPGAHTLILDNSGVQ 239

  Fly   462 YLDAYALNGLYVLSLLSLDNNALIGVH-PDAFRNCSALQDLNLNGNQLKT--VPLALRNMRHLRT 523
            .||.     |..:..|....|.:..:. ||.    |::.:|:|:.|.|..  :|..|..|..|:.
  Fly   240 RLDI-----LGSVHKLQARKNHITEIKLPDK----SSVIELDLHSNLLTATDIPKLLTGMWRLQR 295

  Fly   524 VDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIA-------- 580
            :||.||:|.:.   |..|..|...|.:               ||||..:||:.||:.
  Fly   296 LDLSENIIGIY---AAAGSDNTSELFI---------------LPNLMYMNLSANRLTRLHFDSPI 342

  Fly   581 --------------VVEPG--AFEMTSSIQAVRLDGNELNDIN-GLFSNMPSLLWLNISDNRLES 628
                          :..|.  ..:...::|::.|:||.:|:.. ..:...|||..:.:.||:.:.
  Fly   343 PWERLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVALYDNKFQP 407

  Fly   629 FDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPS---------SIPNS 684
            ..|             || ::...|..|::...|.|     ::|.....|:         ..|.|
  Fly   408 KGY-------------KN-ITKFFNEIGVNVLEKTQ-----YSQSNNTTPTCKPCIPDARDFPTS 453

  Fly   685 IELLFLNDNLITTVDP---DTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGN 746
            |. ...|..:.|.|:|   ||:  :.|:..|.:..:.|.:|.:.|..|:.:...|       |.|
  Fly   454 IS-ADTNQTIDTKVNPLSNDTY--QWNVWNVLMLVSLIVSLFVNSFLIVKLIRLR-------GRN 508

  Fly   747 PFT 749
            .||
  Fly   509 QFT 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	5/16 (31%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	13/70 (19%)
		leucine-rich repeat	229..249	CDD:275380	3/19 (16%)
		LRR_RI	278..468	CDD:238064	56/194 (29%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	301..386	CDD:290566	27/84 (32%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	100/423 (24%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..401	CDD:275380	10/24 (42%)
		LRR_RI	<401..626	CDD:238064	60/257 (23%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	3/22 (14%)
		leucine-rich repeat	450..473	CDD:275380	8/27 (30%)
		leucine-rich repeat	474..497	CDD:275380	4/23 (17%)
		leucine-rich repeat	498..518	CDD:275380	6/21 (29%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..566	CDD:275380	1/20 (5%)
		leucine-rich repeat	569..592	CDD:275380	6/46 (13%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	4/20 (20%)
		leucine-rich repeat	638..662	CDD:275380	4/23 (17%)
		leucine-rich repeat	663..684	CDD:275380	4/29 (14%)
		leucine-rich repeat	685..708	CDD:275380	7/25 (28%)
		leucine-rich repeat	709..728	CDD:275380	4/18 (22%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	2/17 (12%)
		leucine-rich repeat	65..85	CDD:275380	7/24 (29%)
		LRR_8	87..147	CDD:290566	16/60 (27%)
		leucine-rich repeat	89..112	CDD:275380	4/22 (18%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		LRR_RI	<131..334	CDD:238064	68/242 (28%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		LRR_8	140..195	CDD:290566	21/56 (38%)
		leucine-rich repeat	161..184	CDD:275380	10/24 (42%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..246	CDD:275380	11/51 (22%)
		leucine-rich repeat	247..267	CDD:275380	4/23 (17%)
		leucine-rich repeat	268..292	CDD:275380	7/23 (30%)
		leucine-rich repeat	293..322	CDD:275380	11/46 (24%)
		leucine-rich repeat	395..406	CDD:275378	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840