DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and CD180

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_005573.2	Gene:	CD180 / 4064	HGNCID:	6726	Length:	661	Species:	Homo sapiens

Alignment Length:	649	Identity:	149/649 - (22%)
Similarity:	248/649 - (38%)	Gaps:	145/649 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 WPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVN-------- 240
            |..:..|.||:.   |...|.|.||     .:||.:..|   ...|..|.|.|..::
Human    24 WDQMCIEKEANK---TYNCENLGLS-----EIPDTLPNT---TEFLEFSFNFLPTIHNRTFSRLM 77

  Fly   241 ELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRV 305
            .|.|.|.::...|...|.|..:..             .|..|.::.|..:.:........:.|:.
Human    78 NLTFLDLTRCQINWIHEDTFQSHH-------------QLSTLVLTGNPLIFMAETSLNGPKSLKH 129

  Fly   306 LSVNNNGISMIADKALSGLKNLQILNLSSNKI--VALPTELFAEQAKIIQEVYLQNNSISVLNPQ 368
            |.:...|||.:....:..|:||:.|.|.||.|  :..|.:..|...|::.   .|||:|..::.:
Human   130 LFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLD---FQNNAIHYISRE 191

  Fly   369 LFSNLDQLQALDLSMN------------QITSTWIDKNTFVGLIRL-VLLNLSHNKLTK-LEPEI 419
            ...:|:  ||::||:|            ...||......|.|...| |:.|...|..|: |....
Human   192 DMRSLE--QAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGT 254

  Fly   420 FSDL---------------YTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALN 469
            |.|:               .:::.|||:.::..:|::.||.....|..|.|:...||.|.: .:.
Human   255 FEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPS-GMK 318

  Fly   470 GLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPL---ALRNMRHLRTVDLGENMI 531
            ||.:|..|.|..|....:...:..|..:|..|.:.|| :|.:.|   .|..:.:|:|:||..|.|
Human   319 GLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN-VKKLHLGVGCLEKLGNLQTLDLSHNDI 382

  Fly   532 TVME--DSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEP-GAFEMTSSI 593
            ...:  ....|.|.:|..|.|..|....:....|::.|.|::|:||..|:.:..| ..|:....:
Human   383 EASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFL 447

  Fly   594 QAVRLDGNELNDIN-GLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGL 657
            |.:.|....|:..| .|.:.:|.|..||:..|.   |..|.:..|
Human   448 QVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH---FQDGTITKT-------------------- 489

  Fly   658 DSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQIT-- 720
                         |.||.:|      |:|:|.|:...:.::|...|.....::.|||..|.:|
Human   490 -------------NLLQTVG------SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCD 535

  Fly   721 ------------------TLDIKSLRILPVWEHRALPEFYIGGNPFTCDCN----IDWLQKINH 762
                              :::|.|.|:||:...::  ...:..||..|.|:    :.|.::..|
Human   536 SIDSLSHLKGIYLNLAANSINIISPRLLPILSQQS--TINLSHNPLDCTCSNIHFLTWYKENLH 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	15/51 (29%)
		leucine-rich repeat	172..201	CDD:275380	5/16 (31%)
		leucine-rich repeat	202..278	CDD:275380	17/83 (20%)
		leucine-rich repeat	229..249	CDD:275380	7/27 (26%)
		LRR_RI	278..468	CDD:238064	53/220 (24%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	301..386	CDD:290566	26/98 (27%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	8/24 (33%)
		LRR	350..729	CDD:227223	100/434 (23%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..401	CDD:275380	9/36 (25%)
		LRR_RI	<401..626	CDD:238064	65/248 (26%)
		leucine-rich repeat	402..425	CDD:275380	8/39 (21%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	7/22 (32%)
		leucine-rich repeat	521..544	CDD:275380	8/24 (33%)
		leucine-rich repeat	545..566	CDD:275380	5/20 (25%)
		leucine-rich repeat	569..592	CDD:275380	7/23 (30%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	0/23 (0%)
		leucine-rich repeat	663..684	CDD:275380	4/20 (20%)
		leucine-rich repeat	685..708	CDD:275380	5/22 (23%)
		leucine-rich repeat	709..728	CDD:275380	7/38 (18%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CD180	NP_005573.2	leucine-rich repeat	38..57	CDD:275380	7/26 (27%)
		LRR 1	54..75		5/23 (22%)
		leucine-rich repeat	58..78	CDD:275380	4/19 (21%)
		LRR 2	78..99		6/20 (30%)
		leucine-rich repeat	79..102	CDD:275380	6/35 (17%)
		LRR_8	102..161	CDD:290566	15/58 (26%)
		LRR 3	102..123		3/20 (15%)
		leucine-rich repeat	103..126	CDD:275380	3/22 (14%)
		LRR 4	126..147		5/20 (25%)
		leucine-rich repeat	127..150	CDD:275380	6/22 (27%)
		LRR 5	150..171		8/20 (40%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		LRR 6	174..195		5/23 (22%)
		leucine-rich repeat	175..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..234	CDD:275380	10/39 (26%)
		LRR 7	201..221		3/19 (16%)
		leucine-rich repeat	235..275	CDD:275380	8/39 (21%)
		LRR 8	275..296		6/20 (30%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR 9	299..320		6/21 (29%)
		leucine-rich repeat	300..322	CDD:275380	8/22 (36%)
		LRR 10	322..343		4/20 (20%)
		LRR_8	323..382	CDD:290566	17/59 (29%)
		leucine-rich repeat	323..371	CDD:275380	12/48 (25%)
		LRR_RI	327..541	CDD:238064	59/256 (23%)
		LRR 11	346..366		6/20 (30%)
		LRR_8	371..432	CDD:290566	18/60 (30%)
		LRR 12	371..391		6/19 (32%)
		leucine-rich repeat	372..397	CDD:275380	8/24 (33%)
		LRR 13	397..418		5/20 (25%)
		leucine-rich repeat	398..421	CDD:275380	5/22 (23%)
		LRR_8	420..481	CDD:290566	18/63 (29%)
		LRR 14	421..442		6/20 (30%)
		leucine-rich repeat	422..446	CDD:275380	7/23 (30%)
		LRR 15	446..466		5/19 (26%)
		leucine-rich repeat	447..470	CDD:275380	5/22 (23%)
		LRR 16	470..493		8/58 (14%)
		leucine-rich repeat	471..497	CDD:275380	11/67 (16%)
		LRR_8	497..555	CDD:290566	11/57 (19%)
		LRR 17	497..518		6/20 (30%)
		leucine-rich repeat	498..521	CDD:275380	5/22 (23%)
		LRR 18	521..544		5/22 (23%)
		leucine-rich repeat	522..543	CDD:275380	5/20 (25%)
		LRR 19	546..564		3/17 (18%)
		TPKR_C2	577..626	CDD:301599	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820