DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and rtn4rl1b

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_982347.1	Gene:	rtn4rl1b / 403308	ZFINID:	ZDB-GENE-040310-3	Length:	478	Species:	Danio rerio

Alignment Length:	319	Identity:	66/319 - (20%)
Similarity:	113/319 - (35%)	Gaps:	99/319 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 CDCEM--TCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGN------------- 869
            |..|:  :||.:|.|:    .:.:.|.|....:..:|..:|..:..:::..|
Zfish    15 CGLELSWSCPRHCICY----MAPSTVSCQAHNFLSVPEGIPPHSERIFLQNNKIHRLLQGHFSPT 75

  Fly   870 -----------NFVE-----------------------LAGHSFLGRKNLAVLYANNSNVAHIYN 900
                       .::|                       |:..:|.|...|..|:.....::.:.|
Zfish    76 TVTLWIYSNNITYIEPSTFQGFTLLEELDLGDNRYLRSLSAETFHGLGRLHALHLYRCGLSALPN 140

  Fly   901 TTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQ------------- 952
            ..|.||:.|..|:|:|||:..|:.:.|.:|.||..|:|..|::.|:...:|:
Zfish   141 NIFQGLRNLQYLYLQDNHLEYLQDDLFVDLHNLSHLFLHGNRLWSLHQNTFRGLGALDRLLLHHN 205

  Fly   953 -----------MLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCEC------GYLAR 1000
                       .||:|..|.|..|.|.......|:..|.|..:.|.||.|.|:|      .:|.:
Zfish   206 QLQWVDRLAFHDLRRLTTLYLFNNSLTELAGECLTQLPALEYLRLNDNPWECDCKALSLWDWLKK 270

  Fly  1001 FRNYLGQSSEKIIDASRVSCI-----YNNATSVLREKNGTKCTLRDGVAHYMHTNEIEG 1054
            ||.          ..|.|.|:     .......||:::...|:..:.: |...||...|
Zfish   271 FRG----------STSSVGCVAPAELAGKDLKQLRKEDFPNCSGSESL-HQSKTNTWAG 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	20/59 (34%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	9/22 (41%)
		LRR_8	932..990	CDD:290566	19/81 (23%)
		leucine-rich repeat	933..956	CDD:275380	7/46 (15%)
		TIR	1114..1247	CDD:214587
rtn4rl1b	NP_982347.1	leucine-rich repeat	35..56	CDD:275380	4/20 (20%)
		LRR_8	52..109	CDD:290566	2/56 (4%)
		leucine-rich repeat	57..75	CDD:275380	1/17 (6%)
		leucine-rich repeat	77..99	CDD:275380	1/21 (5%)
		LRR_RI	100..>254	CDD:238064	37/153 (24%)
		LRR_8	100..159	CDD:290566	14/58 (24%)
		leucine-rich repeat	100..124	CDD:275380	3/23 (13%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	147..207	CDD:290566	16/59 (27%)
		LRR_4	148..186	CDD:289563	14/37 (38%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..254	CDD:290566	12/56 (21%)
		leucine-rich repeat	197..220	CDD:275380	1/22 (5%)
		leucine-rich repeat	221..244	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100