DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and rtn4r

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_982345.1	Gene:	rtn4r / 403306	ZFINID:	ZDB-GENE-040310-1	Length:	479	Species:	Danio rerio

Alignment Length:	402	Identity:	103/402 - (25%)
Similarity:	164/402 - (40%)	Gaps:	85/402 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIR 401
            :.::|||:....    |.::||:|.::|:....||::..|..|.:..|.|:.  |:...|.||.|
Zfish    48 LFSIPTEIPVRS----QRIFLQSNKLTVVRSTSFSSVHNLTVLWMYSNNISH--IEAGAFYGLER 106

  Fly   402 LVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAY 466
            |..|::..|.                  |||     .|:...|..:..||||.|....|..|...
Zfish   107 LEELDIGDNS------------------NLR-----IISPTAFRGLTKLHTLHLHRCGLSELPVG 148

  Fly   467 ALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMI 531
            ...||:.|..|.|.:|.|:.:|.|.|.:.:.|..|.|:.|::|
Zfish   149 VFRGLFSLQYLYLQDNNLLALHEDTFLDLANLTYLFLHNNKIK---------------------- 191

  Fly   532 TVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAV 596
             |:.|...:||.||..|.|..|.:.::....|.||..|..|.|..|.:.::...:.....|:|.:
Zfish   192 -VVTDHMLRGLVNLDRLLLHQNRIVHVQQQAFNDLSKLTTLFLFFNNLTMLTGESMNPLVSLQYL 255

  Fly   597 RLDGNE-LNDINGLFSNMPSLLWLNI---SDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGL 657
            ||:||: :.|...    .|...|...   |.:.||.    |:|::|...||  .||.|......:
Zfish   256 RLNGNQWICDCRA----RPLWDWFKRFKGSSSDLEC----HLPASLNGKDL--KRLKSDDLEGCV 310

  Fly   658 DSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTV--------DPDTFMHKTNLTRVDL 714
            ||..::||  ..||        |..:|.:.|.|:|.|:.::        |..:.:...::.....
Zfish   311 DSPSQVQT--SIFN--------SKVHSGKFLSLDDPLVESIPRCCLSDNDKSSIISSKSIPDPSS 365

  Fly   715 Y-ANQITTLDIK 725
            | :.|||...:|
Zfish   366 YNSRQITNNPLK 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	34/130 (26%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	13/48 (27%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380	3/12 (25%)
		LRR	350..729	CDD:227223	100/389 (26%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	57/228 (25%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		leucine-rich repeat	498..518	CDD:275380	5/19 (26%)
		leucine-rich repeat	521..544	CDD:275380	4/22 (18%)
		leucine-rich repeat	545..566	CDD:275380	5/20 (25%)
		leucine-rich repeat	569..592	CDD:275380	4/22 (18%)
		leucine-rich repeat	593..615	CDD:275380	6/22 (27%)
		leucine-rich repeat	616..637	CDD:275380	6/23 (26%)
		leucine-rich repeat	638..662	CDD:275380	8/23 (35%)
		leucine-rich repeat	663..684	CDD:275380	5/20 (25%)
		leucine-rich repeat	685..708	CDD:275380	5/30 (17%)
		leucine-rich repeat	709..728	CDD:275380	5/18 (28%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
rtn4r	NP_982345.1	leucine-rich repeat	40..57	CDD:275380	3/8 (38%)
		LRR_8	60..115	CDD:290566	18/56 (32%)
		leucine-rich repeat	60..82	CDD:275380	7/21 (33%)
		leucine-rich repeat	83..106	CDD:275380	8/24 (33%)
		leucine-rich repeat	107..131	CDD:275380	8/46 (17%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		LRR_8	155..214	CDD:290566	22/81 (27%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	9/45 (20%)
		LRR_8	203..261	CDD:290566	17/57 (30%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	228..251	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100