DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and tlr22

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001122147.2 Gene:tlr22 / 403135 ZFINID:ZDB-GENE-040220-5 Length:955 Species:Danio rerio


Alignment Length:1110 Identity:255/1110 - (22%)
Similarity:443/1110 - (39%) Gaps:282/1110 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   190 EIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNG 254
            :|:.:..::...|:.|::|:|.|..:.|..|.:|..|:.||::.|||..|            :||
Zfish    80 QIQIEDLNILLNLQYLNVSNNKISKIQDGAFGSLFNLTDLNLASNRLNAV------------SNG 132

  Fly   255 STESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADK 319
            ....                                         |..|.||.::.|.||:|.:.
Zfish   133 MLRG-----------------------------------------LTNLLVLRLDRNYISVIKES 156

  Fly   320 ALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLN-PQLFSNLDQLQALDLSM 383
            |.|.|.:||:||||.|.:..:........:..::|:|:.:|..:|.| .:|.:....|:.||||.
Zfish   157 AFSTLHSLQVLNLSKNHLRHIDDVKPVLASLYLEELYIGSNYFNVFNSSELSTKPLSLKRLDLSN 221

  Fly   384 NQITSTWIDKNTFVGLIRLVLLNLSHN-----KLTKLEPEIFSDLYTLQILNLRHNQLENIAADT 443
            |:..:..:..|.|..|..|.|....||     .:|  |....:.:.||..:::  |.....|.:.
Zfish   222 NRFAAFQLTNNIFPTLNHLDLSYCGHNGTMAWNVT--EKSYLASVKTLYFMDV--NMSIQTADNV 282

  Fly   444 FAPMNN-LHTLLLSH----NKLKYLDAYALNGLYVLSLLS-----LDNNALIGVHPDAFRNCSAL 498
            ....|| |:.:.|:.    ||...|.:.....|.||.|::     |.|:        .|..||.|
Zfish   283 LQSFNNTLNKIRLNGNVRLNKTSLLLSVCSPMLRVLRLIATKIKHLTNH--------MFDPCSEL 339

  Fly   499 QDLNLNGNQLKTVPLAL-RNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHT 562
            .:|:|.||::..:..:: |..:.|:.:.|..|.:|.:.:| |:.|.:|..:.|..|::..::.:.
Zfish   340 SELDLGGNEISNLSQSMFRGFKQLKKLQLQINKLTRVTNS-FQILTSLEFIDLSRNHIHKLSCND 403

  Fly   563 FRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLL-WLNISDNRL 626
            |.:|..::.|.|..|:|:.:....|:...|::.:||..|.|..|:.:|||.|..| .|.:|.|:|
Zfish   404 FANLTQVKTLYLYSNKISSIRSCLFKDLKSLEVLRLGTNNLLKIDDVFSNGPYFLKELQLSYNKL 468

  Fly   627 ---ESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELL 688
               :|..:|::|. |..|.|..|::|.:..              .:|..|:         ::..|
Zfish   469 SLIKSHTFGNLPQ-LNNLSLEDNQISEIEG--------------YAFGGLE---------NLTSL 509

  Fly   689 FLNDNLIT----TVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFT 749
            ||:.|.||    |..|:.|....||..:||:||.|:                           |.
Zfish   510 FLSSNKITGKTLTTHPNVFSGMPNLQNLDLFANSIS---------------------------FA 547

  Fly   750 CDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHC 814
            .|             ..:||...||:                                       
Zfish   548 YD-------------KLKYPLFKDLK--------------------------------------- 560

  Fly   815 CEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSF 879
                                      |:.|.|                 ||.......:|..:..
Zfish   561 --------------------------NLRELS-----------------LYSQRRGIGQLPSNLL 582

  Fly   880 LGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHI---ISLEGNEFHNLENLRELYLQSN 941
            .|..:|.:.|..|:|:..:....|:...:|..|.|..|.:   .::....||.:.||.:|.:...
Zfish   583 EGLSSLQMFYIGNTNLNQLNPNLFNFTPQLWFLDLSKNALREDDAIPPELFHPIPNLTKLIISRT 647

  Fly   942 KIASI-----ANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARF 1001
            ::.|:     ||     |.||..||..||.:.......:.:.|.|..:.|.:|.::|:|.. |.|
Zfish   648 QLRSLNFLLGAN-----LNKLSTLRASGNEIDSVNETLIKSLPRLAVLDLQNNTFTCDCNN-AFF 706

  Fly  1002 RNYLGQS-SEKIIDASRVSCIYN---NATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVA 1062
            .::..:: |.::...||.:|.|.   ..|| |.|.|...||.......:: .:.|..:|.|||  
Zfish   707 IDWAKKNESTQVYYLSRYTCSYPRTLRGTS-LAEFNTDSCTFNWDYICFV-CSSILVILTLLL-- 767

  Fly  1063 TCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFV 1127
              :|:..|        .|:::   .::....:.|.|.|.|  :|..:....||:.:|:..||.:|
Zfish   768 --SFIWNF--------LRYQV---VYTYYLFLAFLYDSRR--NQSGQTFQYDAFISYNTLDEAWV 817

  Fly  1128 NQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSAL 1192
            .:.|...||.:.|:|||||:||......|.|.:::...|:::.:.::::|:|.:.|...|.:.|.
Zfish   818 MEELIPKLEGEQGWRLCLHHRDFEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCSSEVQVAS 882

  Fly  1193 HELVKRRKRVVFILY-GDLPQRDID--MDMRHYLRTSTCIEW-----DDKKFWQKLRLALPLPNG 1249
            ..|...:|.|:.::: .|:|...:.  ..:|..::..|.|.|     |:|.|||||::||...:.
Zfish   883 FRLFDEQKDVLILVFLEDIPTHQLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKLKMALETKDS 947

  Fly  1250 RGNNN 1254
            ..:.|
Zfish   948 HKSEN 952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566 13/45 (29%)
leucine-rich repeat 172..201 CDD:275380 1/10 (10%)
leucine-rich repeat 202..278 CDD:275380 17/75 (23%)
leucine-rich repeat 229..249 CDD:275380 6/19 (32%)
LRR_RI 278..468 CDD:238064 50/200 (25%)
leucine-rich repeat 279..302 CDD:275380 1/22 (5%)
LRR_8 301..386 CDD:290566 29/85 (34%)
leucine-rich repeat 303..326 CDD:275380 10/22 (45%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR 350..729 CDD:227223 105/403 (26%)
leucine-rich repeat 352..375 CDD:275380 6/23 (26%)
leucine-rich repeat 376..401 CDD:275380 9/24 (38%)
LRR_RI <401..626 CDD:238064 63/241 (26%)
leucine-rich repeat 402..425 CDD:275380 6/27 (22%)
leucine-rich repeat 426..449 CDD:275380 3/22 (14%)
leucine-rich repeat 450..473 CDD:275380 6/26 (23%)
leucine-rich repeat 474..497 CDD:275380 6/27 (22%)
leucine-rich repeat 498..518 CDD:275380 6/20 (30%)
leucine-rich repeat 521..544 CDD:275380 7/22 (32%)
leucine-rich repeat 545..566 CDD:275380 4/20 (20%)
leucine-rich repeat 569..592 CDD:275380 5/22 (23%)
leucine-rich repeat 593..615 CDD:275380 8/21 (38%)
leucine-rich repeat 616..637 CDD:275380 8/24 (33%)
leucine-rich repeat 638..662 CDD:275380 5/23 (22%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 9/26 (35%)
leucine-rich repeat 709..728 CDD:275380 6/18 (33%)
LRR_8 883..943 CDD:290566 14/62 (23%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 6/25 (24%)
LRR_8 932..990 CDD:290566 16/62 (26%)
leucine-rich repeat 933..956 CDD:275380 6/27 (22%)
TIR 1114..1247 CDD:214587 43/140 (31%)
tlr22NP_001122147.2 leucine-rich repeat 458..481 CDD:275380 7/22 (32%)
LRR_RI 461..700 CDD:238064 71/389 (18%)
LRR_8 480..544 CDD:290566 23/87 (26%)
leucine-rich repeat 482..505 CDD:275380 7/45 (16%)
leucine-rich repeat 506..533 CDD:275380 9/26 (35%)
leucine-rich repeat 534..561 CDD:275380 12/131 (9%)
LRR_8 560..622 CDD:290566 16/143 (11%)
leucine-rich repeat 562..587 CDD:275380 6/41 (15%)
leucine-rich repeat 588..606 CDD:275380 4/17 (24%)
leucine-rich repeat 612..638 CDD:275380 6/25 (24%)
LRR_8 637..695 CDD:290566 16/62 (26%)
leucine-rich repeat 639..662 CDD:275380 6/27 (22%)
leucine-rich repeat 663..686 CDD:275380 5/22 (23%)
leucine-rich repeat 687..705 CDD:275380 5/18 (28%)
TIR 802..945 CDD:214587 43/142 (30%)
leucine-rich repeat 71..91 CDD:275380 1/10 (10%)
LRR_8 91..150 CDD:290566 22/111 (20%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
leucine-rich repeat 116..139 CDD:275380 10/75 (13%)
LRR_8 138..199 CDD:290566 20/60 (33%)
leucine-rich repeat 140..163 CDD:275380 10/22 (45%)
leucine-rich repeat 164..213 CDD:275380 13/48 (27%)
leucine-rich repeat 214..338 CDD:275380 34/135 (25%)
LRR_8 337..396 CDD:290566 17/59 (29%)
leucine-rich repeat 339..362 CDD:275380 6/22 (27%)
LRR_RI <363..494 CDD:238064 39/132 (30%)
leucine-rich repeat 363..385 CDD:275380 7/22 (32%)
LRR_8 384..444 CDD:290566 14/59 (24%)
leucine-rich repeat 386..409 CDD:275380 5/22 (23%)
leucine-rich repeat 410..433 CDD:275380 5/22 (23%)
LRR_8 432..492 CDD:290566 22/60 (37%)
leucine-rich repeat 434..457 CDD:275380 9/22 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 219 1.000 Inparanoid score I3549
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.970

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