DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and tlr18

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001082819.1	Gene:	tlr18 / 403133	ZFINID:	ZDB-GENE-040220-2	Length:	854	Species:	Danio rerio

Alignment Length:	1007	Identity:	209/1007 - (20%)
Similarity:	355/1007 - (35%)	Gaps:	315/1007 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 DKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLS 382
            ||..:..|.|:   |.|.....||..|        :|:.|..|:|.|:..|.|..|..|:.|.|:
Zfish    31 DKLSADCKGLR---LDSVPTTQLPDSL--------EELDLSFNTIHVIRKQDFVKLTYLRVLKLN 84

  Fly   383 MNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPM 447
            .|.|:....|  .|.|.:.|..|||.:|.||::..:....|..|::|.:.:|.....
Zfish    85 FNNISLVLDD--AFQGNLLLEELNLFNNSLTEIPFKALEPLTNLKVLEMSNNLYSQA-------- 139

  Fly   448 NNLHTLLLSHNKLKYL-------DAYALNGLYVLSLLSLDNNAL-IGV-----HPDAFRNCSALQ 499
             :|....|:.|:||.|       .:.....:|||..:|||..|: .|.     .|..|::.|...
Zfish   140 -SLGAAFLNFNQLKVLSIGGPLVSSLGSRDIYVLKNISLDKFAVKTGTGFRDYEPGYFKSLSTKH 203

  Fly   500 ---DLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNL-YGLRLIGNYLENITM 560
               |:..:.|. ..:|..|:::.: :|.|: .....:.|...:.|..:: |||:    |:...|:
Zfish   204 LWFDIAFDKNP-DLLPKMLKDLAN-KTFDV-LRFRNLFEFQYYTGKRDIFYGLQ----YVNAQTL 261

  Fly   561 HTFRDLPNLQILNLARNRIAVVEPGAFEMT-------------SSIQAVRLDGNELNDINGLFSN 612
            ..:|...|.:::.:|...:.:....|.|:.             ||::.:.||...|:||:.
Zfish   262 TFYRGKFNEEVMRMALKNVEISPIKALELLLIDFARSQNRTQGSSVKNLSLDRLVLSDISN---- 322

  Fly   613 MPSLL-------WLNISDNRLESF-----DYGHVPSTLQWLDLHKNRLSSLSNRFGLDSEL---- 661
             |.::       ||    |.:..|     ::..||.. .|.::....|..:||...|||.:
Zfish   323 -PDIMRFDWSFTWL----NHVRKFIVWNVNFNSVPCD-SWPEMKSVELLDISNNQLLDSYIYNPL 381

  Fly   662 --------KLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQ 718
                    ||.|.:||.|:|..:.        :|..|..:.:            .||.:|:..||
Zfish   382 CDTRNTLHKLDTFNVSHNRLTSLS--------DLASLTKDFV------------KLTTIDMSHNQ 426

  Fly   719 ITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLN 783
            :.                     |:|..  .|    ||.:.|.                  |::.
Zfish   427 LQ---------------------YLGNG--AC----DWRKTIT------------------KVIG 446

  Fly   784 NRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGA 848
            |                                                 |:...|.:. :|
Zfish   447 N-------------------------------------------------HNSLTSDSF-KC--- 458

  Fly   849 AYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILH 913
                :|..|            ||::|                           ::|.|.:
Zfish   459 ----LPTSV------------NFLDL---------------------------SYSSLDQ----- 475

  Fly   914 LEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSAN 978
                    |:.:.|:....|.||.|..|||..|.:|  ...|.|..|.||||......:......
Zfish   476 --------LDMDYFNKASELTELLLSGNKIKFIPSG--WKNRYLRTLALDGNSFGLVSMKSFKDM 530

  Fly   979 PYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGV 1043
            ..|..::..:|.:.|.|.    ...::.:::.|            ...::....|..||...:.:
Zfish   531 LSLRVLTAGNNPYHCTCD----LYTFIQETTSK------------GKVTITDWPNNYKCYHPERL 579

  Fly  1044 AHYMHTNEIEG-------LLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSP 1101
            .:.|.:....|       |:.::.|:|.|.|.   |:..|.||...:..:..:|..::...|::.
Zfish   580 LNTMVSKYSPGHLACDITLVIIISVSTTAAVV---LVIMLLCYIFHVPWYVKATYQIIRAKYRAH 641

  Fly  1102 RFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLEN-DIGYRLCLHYRDVNINAYITDALIEAAE 1165
            :.......:....|:.:||..|..:|...|...||| ...||||:|.||.....:|.|.:||..|
Zfish   642 KEGLGQGVDYAFHAFISYSHSDADWVRNHLLPCLENVKPPYRLCIHERDFIPGKWIIDNIIENIE 706

  Fly  1166 SAKQFVLVLSKNFLYNEWSRFE-YKSALHELVKRRKRVVFILYGDLPQRDID--------MDMRH 1221
            ::::.:.|||.||:.:||..:| |.:....:.|....|:.::     :..||        ..::.
Zfish   707 NSRKVIFVLSHNFVNSEWCNYELYFAQQRAIGKTFSDVILVV-----KEPIDPTSLPSKFCKLKR 766

  Fly  1222 YLRTSTCIEW-----DDKKFWQKLRLALPLPN 1248
            .|.|.|.:||     :...||.:||..|..||
Zfish   767 MLNTKTYLEWPQQPTEQNFFWIQLRSVLGKPN 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	42/156 (27%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	21/67 (31%)
		leucine-rich repeat	303..326	CDD:275380	2/7 (29%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR	350..729	CDD:227223	97/432 (22%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	57/261 (22%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	3/22 (14%)
		leucine-rich repeat	450..473	CDD:275380	6/29 (21%)
		leucine-rich repeat	474..497	CDD:275380	8/28 (29%)
		leucine-rich repeat	498..518	CDD:275380	4/22 (18%)
		leucine-rich repeat	521..544	CDD:275380	4/22 (18%)
		leucine-rich repeat	545..566	CDD:275380	6/21 (29%)
		leucine-rich repeat	569..592	CDD:275380	3/35 (9%)
		leucine-rich repeat	593..615	CDD:275380	5/21 (24%)
		leucine-rich repeat	616..637	CDD:275380	6/32 (19%)
		leucine-rich repeat	638..662	CDD:275380	7/35 (20%)
		leucine-rich repeat	663..684	CDD:275380	6/20 (30%)
		leucine-rich repeat	685..708	CDD:275380	2/22 (9%)
		leucine-rich repeat	709..728	CDD:275380	5/18 (28%)
		LRR_8	883..943	CDD:290566	9/59 (15%)
		leucine-rich repeat	885..908	CDD:275380	2/22 (9%)
		leucine-rich repeat	909..932	CDD:275380	2/22 (9%)
		LRR_8	932..990	CDD:290566	17/57 (30%)
		leucine-rich repeat	933..956	CDD:275380	9/22 (41%)
		TIR	1114..1247	CDD:214587	44/147 (30%)
tlr18	NP_001082819.1	LRR_8	53..>98	CDD:316378	16/54 (30%)
		leucine-rich repeat	54..77	CDD:275380	9/30 (30%)
		leucine-rich repeat	78..101	CDD:275380	8/24 (33%)
		leucine-rich repeat	102..125	CDD:275380	8/22 (36%)
		leucine-rich repeat	126..150	CDD:275380	5/32 (16%)
		LRR	<345..>519	CDD:227223	59/350 (17%)
		leucine-rich repeat	362..390	CDD:275380	6/27 (22%)
		leucine-rich repeat	391..416	CDD:275380	8/44 (18%)
		leucine-rich repeat	417..440	CDD:275380	10/49 (20%)
		leucine-rich repeat	441..462	CDD:275380	7/95 (7%)
		leucine-rich repeat	463..486	CDD:275380	8/74 (11%)
		leucine-rich repeat	487..508	CDD:275380	9/22 (41%)
		leucine-rich repeat	509..532	CDD:275380	6/22 (27%)
		TIR	653..791	CDD:214587	41/142 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820