DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and tlr4bb

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_997978.2 Gene:tlr4bb / 403132 ZFINID:ZDB-GENE-040219-9 Length:819 Species:Danio rerio


Alignment Length:934 Identity:208/934 - (22%)
Similarity:362/934 - (38%) Gaps:268/934 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   405 LNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALN 469
            |:.|.|.||.|...:|..:..||:|:|....:..|..|.|..:.||.||:|:.|.:.||....||
Zfish    57 LDFSFNFLTSLHKRVFPVMLNLQLLDLTRCYIRQIEKDAFYNVKNLMTLILTGNPITYLAPECLN 121

  Fly   470 GLYVLSLLSLDNNALIGVHPDAFR----NCSALQDLNLNGN--QLKTVPLALRNMRHLRTVDLGE 528
            .||.|..|     .|:.|..::.:    |.:.||||.:..|  |..|:|..:...:....:||..
Zfish   122 SLYKLQRL-----VLVDVRLESLQLQINNLTKLQDLKVGTNCIQSMTLPSFMSTFKDFSLLDLHA 181

  Fly   529 NMITV--MEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTS 591
            |.|::  |:.:|.        ||.||   .|:|            |.|:||.:..:|||||:...
Zfish   182 NNISIIRMDHTAV--------LREIG---RNMT------------LILSRNPLIHIEPGAFKDVI 223

  Fly   592 SIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLS---- 652
                       |.:::        ||...||.|..:              :.|| .|:.|:    
Zfish   224 -----------LRELH--------LLAAFISFNAQK--------------ECHK-ALTGLTVDKL 254

  Fly   653 --NRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIE-LLFLNDNLITTVDPDTFMHKTNLTRVDL 714
              .|:.:|.::|:                |:|:.:| |..:|.|.|..|..:....:.:|.|..:
Zfish   255 FVGRYRMDEKIKV----------------SVPDYLEGLCSINFNEIYLVQKEWSDSEMHLFRCMV 303

  Fly   715 YANQITTLD--IKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQ---------- 767
            .|.:||...  :.|::.:|.  || |.|.|:.      |..:..:..|:||.|.:          
Zfish   304 NATKITIKKAYMNSMKHIPF--HR-LKELYLS------DTGLSVVPFISHIPSLEKLVMKSPFPI 359

  Fly   768 ------------------------------YPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLC 802
                                          :||..:::  |..|..|.|..::    .||     
Zfish   360 TFTGVSDLPLLQYVDLSGNMLILHECCSILFPRTPNIQ--YLNLSQNSEITFV----NEP----- 413

  Fly   803 TYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVP-MDTSELYI 866
                          |.|.|.     .....||    .|.:|......:.:..|.:. :|.|...:
Zfish   414 --------------FSALDL-----LEVLDFH----HTKLVIVFYFGFFKHLRNLKYLDISYTRV 455

  Fly   867 DGNNF----------VELAGHSFLGRK---------NLAVLYANNSNVAHIYNTTFSGLKRLLIL 912
            ..|..          :::||:||.|.|         :|.||..:...:..:...:|:|.::|..|
Zfish   456 HFNTLTFQDLHNLTVLKMAGNSFSGDKLSYFLQNLTSLEVLDISQCGIEKVSMRSFTGTQKLRHL 520

  Fly   913 HLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSA 977
            :|..|.::.|:......|.:|..:|:..|.|.:|         .|:||:            :|..
Zfish   521 YLSRNKLMVLDFLTQPELTHLTSVYIDKNSITTI---------PLDVLQ------------KLPM 564

  Fly   978 NPYLVEISLADNQWSCECG------YLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTK 1036
            |  |.|..|:.|...|.|.      ::.:.:|.|.|       ...:.|...:|.:..:      
Zfish   565 N--LSEFDLSSNSIDCSCSQTDFILWIIQKQNILKQ-------LENIRCKTFSANTDFK------ 614

  Fly  1037 CTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFC-YKS 1100
             .:...:.:.:|...:..:|.::.|.       |.::..:..|    |.|.:...|.:.|. |:|
Zfish   615 -AIDFDIDYCVHKKRLTIVLSVICVT-------FVVVLAILLY----KFWFYVQYCFILFSGYRS 667

  Fly  1101 PRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDI-GYRLCLHYRDVNINAYITDALI-EA 1163
            |.     .:|...||:..:|..||.:|...|.:.|||.: ..:||||.||......|...:| |.
Zfish   668 PG-----QQECSYDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNIIDEG 727

  Fly  1164 AESAKQFVLVLSKNFLYNEWSRFEYKSALHE-LVKRRKRVVFILYGDLPQRDID--MDMRHYLRT 1225
            ...:::.::|:|::|:.:.|.|||::.|... |::|...::.|:..|:.:|...  ..:..:|:.
Zfish   728 IMGSRKIIVVVSQHFIDSSWCRFEFELAQSRFLMERNANIIIIILEDVAERKTKKVFGLHKHLKK 792

  Fly  1226 STCIEW-----DDKKFWQKLRLAL 1244
            :|.::|     .:.:||.:||.|:
Zfish   793 NTYLKWSRDPLSNMRFWIRLRKAI 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 22/62 (35%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223 87/340 (26%)
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
LRR_RI <401..626 CDD:238064 66/228 (29%)
leucine-rich repeat 402..425 CDD:275380 7/19 (37%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 10/22 (45%)
leucine-rich repeat 474..497 CDD:275380 5/26 (19%)
leucine-rich repeat 498..518 CDD:275380 8/21 (38%)
leucine-rich repeat 521..544 CDD:275380 6/24 (25%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 1/21 (5%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 6/29 (21%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 6/23 (26%)
leucine-rich repeat 709..728 CDD:275380 6/20 (30%)
LRR_8 883..943 CDD:290566 15/68 (22%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 13/57 (23%)
leucine-rich repeat 933..956 CDD:275380 5/22 (23%)
TIR 1114..1247 CDD:214587 40/141 (28%)
tlr4bbNP_997978.2 leucine-rich repeat 56..77 CDD:275380 7/19 (37%)
LRR_8 77..133 CDD:290566 22/60 (37%)
leucine-rich repeat 78..101 CDD:275380 7/22 (32%)
leucine-rich repeat 102..125 CDD:275380 10/22 (45%)
leucine-rich repeat 126..148 CDD:275380 5/26 (19%)
leucine-rich repeat 149..173 CDD:275380 8/23 (35%)
leucine-rich repeat 174..200 CDD:275380 10/36 (28%)
leucine-rich repeat 201..222 CDD:275380 11/32 (34%)
LRR_RI <325..531 CDD:238064 43/246 (17%)
leucine-rich repeat 326..369 CDD:275380 8/48 (17%)
leucine-rich repeat 370..395 CDD:275380 2/24 (8%)
LRR_8 394..455 CDD:290566 16/94 (17%)
leucine-rich repeat 396..419 CDD:275380 8/47 (17%)
leucine-rich repeat 420..444 CDD:275380 4/27 (15%)
LRR_8 443..527 CDD:290566 19/83 (23%)
leucine-rich repeat 445..467 CDD:275380 3/21 (14%)
leucine-rich repeat 468..492 CDD:275380 6/23 (26%)
LRR_8 491..576 CDD:290566 25/107 (23%)
leucine-rich repeat 493..516 CDD:275380 5/22 (23%)
leucine-rich repeat 517..540 CDD:275380 6/22 (27%)
leucine-rich repeat 541..565 CDD:275380 9/44 (20%)
TIR 675..816 CDD:214587 39/140 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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