DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and tlr9

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001124066.1 Gene:tlr9 / 403128 ZFINID:ZDB-GENE-040219-10 Length:1057 Species:Danio rerio


Alignment Length:920 Identity:213/920 - (23%)
Similarity:356/920 - (38%) Gaps:256/920 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 AGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIM 132
            |...|..|  |.:.|     ......|.:.|..|.::.....|:.|||...       |.|:.| 
Zfish    19 AASHPQFY--PCESH-----STKDGHINVDCQHRRLSKVPRFTSPSVISLN-------LNNNHI- 68

  Fly   133 AKSRLEAQSFAHLVRLQQLSIQY-CKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAF 196
              .|::..:|:.|..|:.||:.: |        :.|.|::.|          ||..:..|:.|||
Zfish    69 --HRIKGDAFSGLPNLKYLSLMWNC--------ISDRLKEAR----------WPLCSVNIDPDAF 113

  Fly   197 SVTRRLERLDLSSNNIWSLP-------------DNIFCTLS-----ELSALNMSEN--------R 235
            ...:.|..|.|:.|::..:|             :|||..:.     :|..|.:|:|        :
Zfish   114 VGLKNLTSLQLAGNSLKMIPPLPKQLEVLGLEFNNIFNIVKPLGTPQLKQLLLSKNCFYANPCHQ 178

  Fly   236 LQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTL 300
            ...:|...|:|..                             :|..|.:|:|:...:|:...|:|
Zfish   179 PYFINSSVFQDLP-----------------------------ELLNLTLSYNNLTAIPSYLPGSL 214

  Fly   301 RRLRVLSVNNNGISMIADKALSGLKNLQILNLS-----------------SNKIVALPTELFAEQ 348
            ..   |.:..|.|..|..::.:.|:||:.|||.                 :|:.:.|..:.|.:|
Zfish   215 ES---LDLRENTIDHINKESFANLRNLRHLNLGWNCQRCDHASDPCFPCPNNQSLDLHQDAFLDQ 276

  Fly   349 AKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFV-GLIRLVLLNLSHN-K 411
            ...:..::||.||:..|...||.||.:||.||||.|.:..| |...||. .|..:|:|||.:| :
Zfish   277 RDSLVSLHLQGNSLRTLPRHLFINLHKLQELDLSSNFLAFT-IQNGTFYEELQNVVILNLLYNYE 340

  Fly   412 LTKLEPEIFSDLYTLQILNLRHNQL-----ENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGL 471
            ..|..||:....|..::.:||...|     :.::..:.||:..|..|.:...::.::...:::||
Zfish   341 PLKTFPELNLSPYIEKMASLRELYLSGFFFKKLSNRSIAPLVKLPRLEVLDLRMNFICDISIDGL 405

  Fly   472 YVLSLL---SLDNNALIGVHPDAFRNCSAL---------------QDLNLNGNQLKTVPLA---- 514
            ..|..|   .|..|.|      ||.:|.:.               :..||   |::.:|:.    
Zfish   406 SQLRTLRRVDLSQNML------AFSSCFSTCTSEAEHQIPERYGNEQFNL---QMQELPILNAET 461

  Fly   515 ----------LRNMRHLRT--------VDLGENMITVMEDSAFKGLGNLYGLRLIGNYL-ENITM 560
                      ..:|.|.:.        .||.:|.|..:..|.|:|:..:..:.|..||: :.:..
Zfish   462 QGSKPDYCSFYFSMWHFKRQICSKSLYFDLSQNNIPWLNASTFRGMDRVACVDLSYNYISQTLNG 526

  Fly   561 HTFRDLPNLQILNLARNRIAVVEPGAF-EMTSSIQAVRLDGNEL--------------------- 603
            |.|..|..|..||:|.|||.:....|| |::.:::|:.|..||.                     
Zfish   527 HQFSHLSKLSYLNMAYNRIDLYSDKAFQEVSGTLKALDLSNNEFHFIMKGMGHQFTFLTHMSSLI 591

  Fly   604 ------NDINGLFSNM---PSLLWLNISDNRL----ESFDYGHVP-----STLQWLDLHKNRLSS 650
                  |.|....||:   .||.:|..|.|||    :|:...::.     :.|..||:.:|:|.|
Zfish   592 ILSLANNHIGLRISNILTSASLKYLIFSGNRLDILWDSWRNQYINLFQGLTNLTHLDISENQLKS 656

  Fly   651 LSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLN--DNL------------ITTVD-- 699
            ||....::..|.||.|.|.||.|.....::|....:|.:||  .|:            :|.:|  
Zfish   657 LSPEVIVNLPLSLQVLRVDFNMLTYFPWANISVLQKLCYLNLSSNMLSYLPNINFELRLTGLDLS 721

  Fly   700 -------PDTFMHK-TNLTRVDLYANQITTLDIKSLRI--------LPVWEH--RALPEFYIGGN 746
                   |..|:.: .||..::|..||:..||:::|.:        :|..:|  |:..:..:..|
Zfish   722 HNRLVAIPKVFLSQAANLKNLNLNNNQLKILDVQALPLPFHKGCTFIPGGQHKNRSSCKLVLHAN 786

  Fly   747 PFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKH---------FLC 802
            ||||.|.|....|....|....|.:  ...::|..  ....|.:.::..:.:.         |||
Zfish   787 PFTCSCVISGFAKFLRETDLDVPHL--TTQVHCGF--PESLAGVNVLSVDLRSCQEIFGGVAFLC 847

  Fly   803 TYKTHCFAVC 812
            |......|.|
Zfish   848 TSLLTLAATC 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 6/23 (26%)
LRR_8 171..236 CDD:290566 19/90 (21%)
leucine-rich repeat 172..201 CDD:275380 7/28 (25%)
leucine-rich repeat 202..278 CDD:275380 15/101 (15%)
leucine-rich repeat 229..249 CDD:275380 6/27 (22%)
LRR_RI 278..468 CDD:238064 58/213 (27%)
leucine-rich repeat 279..302 CDD:275380 7/22 (32%)
LRR_8 301..386 CDD:290566 30/101 (30%)
leucine-rich repeat 303..326 CDD:275380 5/22 (23%)
leucine-rich repeat 327..350 CDD:275380 8/39 (21%)
LRR 350..729 CDD:227223 125/490 (26%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 12/25 (48%)
LRR_RI <401..626 CDD:238064 68/302 (23%)
leucine-rich repeat 402..425 CDD:275380 8/23 (35%)
leucine-rich repeat 426..449 CDD:275380 5/27 (19%)
leucine-rich repeat 450..473 CDD:275380 4/22 (18%)
leucine-rich repeat 474..497 CDD:275380 8/25 (32%)
leucine-rich repeat 498..518 CDD:275380 4/48 (8%)
leucine-rich repeat 521..544 CDD:275380 7/30 (23%)
leucine-rich repeat 545..566 CDD:275380 5/21 (24%)
leucine-rich repeat 569..592 CDD:275380 10/23 (43%)
leucine-rich repeat 593..615 CDD:275380 8/51 (16%)
leucine-rich repeat 616..637 CDD:275380 7/29 (24%)
leucine-rich repeat 638..662 CDD:275380 8/23 (35%)
leucine-rich repeat 663..684 CDD:275380 8/20 (40%)
leucine-rich repeat 685..708 CDD:275380 8/46 (17%)
leucine-rich repeat 709..728 CDD:275380 6/18 (33%)
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
tlr9NP_001124066.1 leucine-rich repeat 39..57 CDD:275380 3/17 (18%)
LRR_8 56..129 CDD:290566 26/100 (26%)
leucine-rich repeat 58..81 CDD:275380 8/32 (25%)
LRR_RI <73..312 CDD:238064 66/288 (23%)
leucine-rich repeat 82..118 CDD:275380 13/53 (25%)
leucine-rich repeat 119..138 CDD:275380 5/18 (28%)
leucine-rich repeat 139..192 CDD:275380 10/81 (12%)
LRR_8 191..246 CDD:290566 17/86 (20%)
leucine-rich repeat 193..213 CDD:275380 5/19 (26%)
leucine-rich repeat 214..237 CDD:275380 6/25 (24%)
leucine-rich repeat 238..279 CDD:275380 8/40 (20%)
LRR_RI 274..>422 CDD:238064 45/154 (29%)
leucine-rich repeat 280..303 CDD:275380 9/22 (41%)
leucine-rich repeat 304..323 CDD:275380 9/19 (47%)
leucine-rich repeat 360..386 CDD:275380 6/25 (24%)
leucine-rich repeat 387..408 CDD:275380 3/20 (15%)
LRR_8 490..545 CDD:290566 18/54 (33%)
leucine-rich repeat 490..509 CDD:275380 7/18 (39%)
leucine-rich repeat 510..534 CDD:275380 6/23 (26%)
leucine-rich repeat 535..559 CDD:275380 10/23 (43%)
leucine-rich repeat 560..589 CDD:275380 4/28 (14%)
leucine-rich repeat 590..612 CDD:275380 4/21 (19%)
LRR_8 612..679 CDD:290566 23/66 (35%)
leucine-rich repeat 613..643 CDD:275380 7/29 (24%)
leucine-rich repeat 644..668 CDD:275380 8/23 (35%)
leucine-rich repeat 669..692 CDD:275380 8/22 (36%)
leucine-rich repeat 693..714 CDD:275380 4/20 (20%)
TIR_2 894..1040 CDD:304906
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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