DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and tlr2

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:XP_005170910.1 Gene:tlr2 / 403125 ZFINID:ZDB-GENE-040219-6 Length:818 Species:Danio rerio


Alignment Length:938 Identity:195/938 - (20%)
Similarity:345/938 - (36%) Gaps:279/938 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   401 RLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDA 465
            ::...|.|.|.|.:: |.:.||:..   |:|..||:|:|.....:..|.|..|.|..|||:::..
Zfish    61 QMYFCNCSSNNLHQV-PTVPSDVLG---LDLSFNQIESINMTDLSSYNELIILNLHKNKLRHIHR 121

  Fly   466 YALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLA--LRNMRHLRTVDLGE 528
            .|....:.|.:|.|..|.|..:.|..|....:||.|||.||...||..|  .:::.:|||:.||.
Zfish   122 DAFKSQHNLEVLDLSLNNLNNLSPSWFHKLKSLQQLNLVGNPYSTVGPAPIFKSLVNLRTLHLGS 186

  Fly   529 -----------NMITVMEDSAFKGL-------GNLYGLRLIGNY---LEN-------ITMHTFRD 565
                       :::|.:::..|.|.       |:|...|.||:.   |:|       :.....:|
Zfish   187 PSLRELHKNGLDVLTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLSLQNLFESDPELVSKVLQD 251

  Fly   566 LPNLQIL----------NLARNRIAVVEPG-----AFEMTSSI-QAVR-----LDGNELNDINGL 609
            :.:.:.|          |.:.....:|:.|     .|:.:|:. ||:.     :||:.|:     
Zfish   252 VSHPETLLIIKDVTMKTNTSTEPFKMVKEGGTKSLTFQNSSTTDQALTSFLEFMDGSPLS----- 311

  Fly   610 FSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSN-----RFGLDSELKLQTLDVS 669
            |..:..:.::.|.:  .:...|.|..|.         |.:.|.|     .||..|.::|..|...
Zfish   312 FIGLEDIQFVGIGE--WQKAKYTHHDSL---------RTAYLRNIEIEGFFGFSSMIELGFLLKH 365

  Fly   670 FNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWE 734
            |:.:.              .:|..:.......||:.| ||..:||..|.:|.|.|:         
Zfish   366 FHNVS--------------VINATVFVIPKETTFLLK-NLEYMDLSQNLLTDLTIQ--------- 406

  Fly   735 HRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKH 799
                |..|.|...:         |.:|.:...|  .::....:..:|:.|.::.         |:
Zfish   407 ----PTLYTGSGAY---------QNLNMLNVSQ--NVLKSLGLMSRLVTNLKKL---------KY 447

  Fly   800 FLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSEL 864
            ...:|.:.                ::.|..|      :|...:                      
Zfish   448 LDLSYNSF----------------VSMPEKC------SWPVTL---------------------- 468

  Fly   865 YIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGL-----KRLLILHLEDNHIISLEG 924
                 .|:.|:                        :|..|.|     ..|.:|.|.:|.:.:.: 
Zfish   469 -----RFLNLS------------------------STKLSTLTPCLPSSLTVLDLSENDLKAFK- 503

  Fly   925 NEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADN 989
               ....:|..|.|..|::..:.:|  ::...|..|.:..|.|..|....|.:...|:.:....|
Zfish   504 ---QRFPHLTTLILTGNRLMKLPDG--KLFPSLNTLLIQRNALRMFNQSSLRSFKTLLYLEAGAN 563

  Fly   990 QWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHY-------M 1047
            .:.|.|.:::.|:    :..|.:|                        ||:||..:|       :
Zfish   564 NFVCSCKFVSFFK----KDVEDLI------------------------TLQDGRQNYVCNTPFTL 600

  Fly  1048 HTNEIEG---------LLPLLLVATCAFVAFFGLIFGLFCYR-HEL------KIWAHSTNCLMNF 1096
            ..|.|:.         ::|.:.|.....:...||:. |.|:: |.:      |.|..:       
Zfish   601 RGNAIDSVRLSVFECYMIPAVSVLCFGIITALGLVV-LTCHKLHVIWYLQMTKAWIQA------- 657

  Fly  1097 CYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLEN-DIGYRLCLHYRDVNINAYITDAL 1160
              |....|.:|.:|...||:.:||..|..:|.:||...||: ...:.||||.||.....:|.|.:
Zfish   658 --KRKPAVGRLPEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHKRDFRPGRWIVDNI 720

  Fly  1161 IEAAESAKQFVLVLSKNFLYNEWSRFEYK-SALHELVKRRKRVVFILYGDLPQRDID---MDMRH 1221
            |::.|.:.:.:.|||::|:.:||.|:|.. |....:.:.....|.:|...:.:..|.   ..:|.
Zfish   721 IDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFRIMDEHNDSAVLVLLEPIKKETIPKRFCKLRK 785

  Fly  1222 YLRTSTCIEW---DDKK--FWQKLRLAL 1244
            .:.:.|.:||   :||:  ||..||.||
Zfish   786 IMNSRTYLEWPEDEDKRDEFWSNLRAAL 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 20/66 (30%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223 91/383 (24%)
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380 195/938 (21%)
LRR_RI <401..626 CDD:238064 67/275 (24%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 7/22 (32%)
leucine-rich repeat 498..518 CDD:275380 10/21 (48%)
leucine-rich repeat 521..544 CDD:275380 8/40 (20%)
leucine-rich repeat 545..566 CDD:275380 6/30 (20%)
leucine-rich repeat 569..592 CDD:275380 5/37 (14%)
leucine-rich repeat 593..615 CDD:275380 6/27 (22%)
leucine-rich repeat 616..637 CDD:275380 3/20 (15%)
leucine-rich repeat 638..662 CDD:275380 6/28 (21%)
leucine-rich repeat 663..684 CDD:275380 3/20 (15%)
leucine-rich repeat 685..708 CDD:275380 4/22 (18%)
leucine-rich repeat 709..728 CDD:275380 7/18 (39%)
LRR_8 883..943 CDD:290566 11/64 (17%)
leucine-rich repeat 885..908 CDD:275380 3/27 (11%)
leucine-rich repeat 909..932 CDD:275380 4/22 (18%)
LRR_8 932..990 CDD:290566 12/57 (21%)
leucine-rich repeat 933..956 CDD:275380 5/22 (23%)
TIR 1114..1247 CDD:214587 44/141 (31%)
tlr2XP_005170910.1 leucine-rich repeat 85..105 CDD:275378 6/19 (32%)
leucine-rich repeat 106..129 CDD:275378 7/22 (32%)
LRR_8 108..163 CDD:290566 19/54 (35%)
leucine-rich repeat 130..153 CDD:275378 7/22 (32%)
leucine-rich repeat 154..178 CDD:275378 10/23 (43%)
leucine-rich repeat 179..192 CDD:275378 5/12 (42%)
LRR_RI <390..501 CDD:238064 29/216 (13%)
leucine-rich repeat 390..418 CDD:275380 10/49 (20%)
LRR_8 418..478 CDD:290566 12/143 (8%)
leucine-rich repeat 419..444 CDD:275380 4/26 (15%)
leucine-rich repeat 445..467 CDD:275380 5/52 (10%)
leucine-rich repeat 468..488 CDD:275380 5/70 (7%)
leucine-rich repeat 489..508 CDD:275380 4/22 (18%)
leucine-rich repeat 509..530 CDD:275380 5/22 (23%)
leucine-rich repeat 531..554 CDD:275380 6/22 (27%)
TIR 671..814 CDD:214587 44/143 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.