back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and CG4950

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	115/503 - (22%)
Similarity:	210/503 - (41%)	Gaps:	101/503 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 RLQDVNELGFRDRSKE--PTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGF 297
            |..:.:.:|:.|.::.  ...|.|.:.|.....|.....:.     ::::....:..:.:|.:.|
  Fly    31 RCDEYDSMGYMDVNEAFCTVTGFTVTHSQNVVIKNIPPGNM-----VKFMKFYESTLLYMPFHLF 90

  Fly   298 GTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSI 362
            .|...|:.|.|:|..|..:...|.|...||..|||:.|.:.::.|.:|. .|.::..:.|..|.|
  Fly    91 ETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFI-GANVLMRLDLSYNEI 154

  Fly   363 SVLNPQLFSNLDQLQALDLSMNQI---------TSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPE 418
            |.|:...|..|..:..:.|:.|.:         .:.:::|.:|.|           |.||.::||
  Fly   155 SSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEG-----------NLLTSIQPE 208

  Fly   419 IFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNA 483
            :|.::..::.:||.:|:|..|..||||...:|..|:||:|:||   .:.|....::..|.||||.
  Fly   209 VFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELK---NFQLTEKNIVHQLHLDNNY 270

  Fly   484 LIGVHPDAFRNCSA---------------LQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITV 533
            |..:..:|.|...|               ::.|:|:.|:|.::. .:.|:.|:..:|:.:|.|..
  Fly   271 LTNLTINATRFVRASHNQISELFLHQSLHIETLDLSANKLSSIS-NITNITHMLYLDVSDNPIGP 334

  Fly   534 MEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAF-EMTSSIQAVR 597
            :..|.|..|..|.||.|.|..:..:....|.....|:.|:|:.|.:.::....| ...::::...
  Fly   335 LNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFL 399

  Fly   598 LDGNELNDING--LFSN-MPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDS 659
            :|||.|.::.|  .||. .|.|..|.:|.||.......|:
  Fly   400 IDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHL------------------------- 439

  Fly   660 ELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKT 707
                            :.|.|:|.|:         :..::|||.:.:|
  Fly   440 ----------------LIPPSLPESV---------VLNIEPDTNLDET 462

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.