DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and caps

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	154/590 - (26%)
Similarity:	230/590 - (38%)	Gaps:	155/590 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNP--QLFSNLDQLQALDLSMNQITSTWI 391
            ::|.....:..||..|    ...||.:.::||.:..::.  |.::   ||..||||.|.:.:  |
  Fly    55 MVNCGEGTLDVLPIAL----NPAIQRLVIKNNKLKTIDSSMQFYA---QLTFLDLSFNDMLT--I 110

  Fly   392 DKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLS 456
            .:.:|....:|..|:|.|||:.::..:.|..|.|:.:||||.|.:..:...||:||..|..|.|.
  Fly   111 PERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLG 175

  Fly   457 HNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPD-AFRNCSALQDLNLNGNQLKTVP-LALRNMR 519
            .|::.::|.:||:||..|.:|.||:|.|..|..: .|:...:|.:|.|..|...|:| .|.::::
  Fly   176 QNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLK 240

  Fly   520 HLRTVDL-GENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVE 583
            .|..:|| |..:..:..| |.|||.:|..|.|..|.|..|....|:.|..|:.||:.:|...|:.
  Fly   241 GLTRLDLRGAGLHNISGD-ALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVIS 304

  Fly   584 PGAFEMTSSIQAVRLDG-NELNDI-NGLFSNMPSLLWLNISDNR----LESFDYGHVPSTLQWLD 642
            .|||.....::.:.|.| ..|..: :|.||...:|..||:|.|:    |.|...|.:|. |..:.
  Fly   305 SGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPH-LSTVV 368

  Fly   643 LHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKT 707
            |..|:||||..  ||.....|||||:|
  Fly   369 LKANQLSSLDE--GLVPWADLQTLDLS-------------------------------------- 393

  Fly   708 NLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIM 772
                                                 .|||.|||.:.||:.:  :.||
  Fly   394 -------------------------------------ENPFECDCRLLWLRHL--LVSR------ 413

  Fly   773 DLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKT--HCFAVCHCCEFDACDCEMTCPTNCTCFHD 835
                       |....|.|:|        |.|.|  ....:.|..|          |. ..|.|.
  Fly   414 -----------NASGQYAPVI--------CAYPTALRDLPLAHLAE----------PL-LGCAHG 448

  Fly   836 QTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVE-LAGHSFLGRKNLAVLYANNSNVAHIY 899
            ......|:.....|.:.:...:.:   .||...:...| |.|||.||||.            ..|
  Fly   449 AASKQAIIGILVVACAALITTLAL---VLYTCRHRIREMLKGHSALGRKE------------REY 498

  Fly   900 NTTFS 904
            ..|||
  Fly   499 QKTFS 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	41/140 (29%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	16/58 (28%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380	4/20 (20%)
		LRR	350..729	CDD:227223	111/389 (29%)
		leucine-rich repeat	352..375	CDD:275380	5/24 (21%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	78/233 (33%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	8/23 (35%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	9/23 (39%)
		leucine-rich repeat	545..566	CDD:275380	7/20 (35%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	6/23 (26%)
		leucine-rich repeat	616..637	CDD:275380	9/24 (38%)
		leucine-rich repeat	638..662	CDD:275380	9/23 (39%)
		leucine-rich repeat	663..684	CDD:275380	6/20 (30%)
		leucine-rich repeat	685..708	CDD:275380	0/22 (0%)
		leucine-rich repeat	709..728	CDD:275380	0/18 (0%)
		LRR_8	883..943	CDD:290566	5/22 (23%)
		leucine-rich repeat	885..908	CDD:275380	4/20 (20%)
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/23 (17%)
		LRR_8	96..155	CDD:290566	23/60 (38%)
		leucine-rich repeat	97..120	CDD:275380	8/24 (33%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	23/57 (40%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		LRR_RI	147..397	CDD:238064	89/328 (27%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	20/59 (34%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	9/23 (39%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		LRR_8	312..374	CDD:290566	18/62 (29%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	8/23 (35%)
		LRRCT	395..445	CDD:214507	20/87 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840