DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and chad

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_957357.1 Gene:chad / 394038 ZFINID:ZDB-GENE-040426-1130 Length:363 Species:Danio rerio


Alignment Length:364 Identity:94/364 - (25%)
Similarity:160/364 - (43%) Gaps:87/364 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   315 MIADKALSGLKNL-------QILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSN 372
            :|.|..  |||.:       ::|||..|.:..|||..|:|...:| .::||:..|..|:.|.|. 
Zfish    40 VICDNV--GLKKIPRISEATRLLNLQRNNLGNLPTGGFSEMKGLI-SLHLQHCQIRELSGQAFK- 100

  Fly   373 LDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLE 437
                                     ||.:|:.|.||.|:::.::|..|.||..|..|.|..||:.
Zfish   101 -------------------------GLNKLIYLYLSDNEISTIKPGAFEDLTELTYLYLDGNQIT 140

  Fly   438 NIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLN 502
            ::....|:||.||..|.|::|||:.|......|...|..|.:..|.|..:.|.:......|..|.
Zfish   141 SLPKGIFSPMINLFILQLNNNKLRELQPGTFKGAKDLRWLYMSGNELSSIQPGSLDEVENLAILT 205

  Fly   503 LNGNQLKTVP-LALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDL 566
            |:.|.|.|.| ||:..:|.:..::|.:|.::::.|.||         |..|.|:|.:        
Zfish   206 LDQNNLSTYPLLAMSKLRVVEELNLSKNPLSLIPDHAF---------RSFGRYMEKL-------- 253

  Fly   567 PNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGL-FSNMPSLLWLN--------I 621
             :|..::|.:     ....|||..::::::.|:.|:|..: |.| ||.:.::...|        :
Zfish   254 -HLNDMSLEK-----FSNAAFEGVTALKSLHLENNKLRSLPNSLEFSTIQNITLFNNPWSCTCPL 312

  Fly   622 SDNRLESFDYGHVPSTLQWLDLHKNR----LSSLSNRFG 656
            ::.|             :|:|..:||    .:|.:|:.|
Zfish   313 TNLR-------------KWMDTTRNRPDAVCASPANQKG 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 48/159 (30%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566 21/77 (27%)
leucine-rich repeat 303..326 CDD:275380 4/10 (40%)
leucine-rich repeat 327..350 CDD:275380 9/29 (31%)
LRR 350..729 CDD:227223 80/322 (25%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 2/24 (8%)
LRR_RI <401..626 CDD:238064 63/235 (27%)
leucine-rich repeat 402..425 CDD:275380 9/22 (41%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..518 CDD:275380 9/20 (45%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 4/20 (20%)
leucine-rich repeat 569..592 CDD:275380 5/22 (23%)
leucine-rich repeat 593..615 CDD:275380 7/23 (30%)
leucine-rich repeat 616..637 CDD:275380 2/28 (7%)
leucine-rich repeat 638..662 CDD:275380 7/23 (30%)
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
chadNP_957357.1 LRRNT 26..52 CDD:279764 5/13 (38%)
leucine-rich repeat 57..80 CDD:275380 9/22 (41%)
LRR_8 79..139 CDD:290566 22/86 (26%)
leucine-rich repeat 81..104 CDD:275380 9/49 (18%)
LRR_RI <96..304 CDD:238064 66/256 (26%)
LRR_4 104..143 CDD:289563 14/38 (37%)
leucine-rich repeat 105..128 CDD:275380 9/22 (41%)
LRR_8 127..187 CDD:290566 20/59 (34%)
leucine-rich repeat 129..152 CDD:275380 8/22 (36%)
leucine-rich repeat 153..176 CDD:275380 8/22 (36%)
LRR_8 177..235 CDD:290566 17/57 (30%)
leucine-rich repeat 177..200 CDD:275380 5/22 (23%)
leucine-rich repeat 201..224 CDD:275380 9/22 (41%)
LRR_8 225..284 CDD:290566 16/81 (20%)
leucine-rich repeat 225..248 CDD:275380 6/31 (19%)
leucine-rich repeat 250..273 CDD:275380 6/36 (17%)
LRRCT 304..351 CDD:214507 8/48 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.100

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