DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and CG6749

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	148/565 - (26%)
Similarity:	231/565 - (40%)	Gaps:	120/565 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAK 134
            |.|.|:.| |.|..:........|:|...:|..:.:|    |:      ||:|:..: ..|:...
  Fly    19 GFPILHGA-DLCQPIGWRNFQCSEVASLQDLVDLGAE----NW------HTLAIRNV-QTELEVG 71

  Fly   135 SRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVT 199
            |...|...|:|:.|.........:...|..:|..|.||        |:....| .:|..:.|:..
  Fly    72 SGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQL--------NLSGCGL-VDIRGNHFAPE 127

  Fly   200 RRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTES 264
            ..|:|:|.|.|.:..|..:.|..|.:|...|.|.|.|:
  Fly   128 SALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALK--------------------------- 165

  Fly   265 AKKSSSSSTSCSLD----LEYLDVSHNDFVVLPANG-FGTLRRLRVLSVNNNGISMIADKALSGL 324
                     .|.|.    |..|::.||..|    |. ||...:|:.|.:|:|.:..:...|..||
  Fly   166 ---------QCDLPHMPLLNRLELGHNRLV----NATFGVCPQLQELILNDNQLIQLDVNAFRGL 217

  Fly   325 KNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLD----QLQALDLSMNQ 385
            ..|..|.||.|::.::..|.|...|: ::::.|..|::..|.|.:|..:.    .||.||||.|:
  Fly   218 HGLLELQLSGNRLSSIGLETFQPLAQ-LRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNR 281

  Fly   386 ITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNL 450
            |...:  .|.|..|.||.:|::|.|.:..|.|..|..|.:|:.|.|::|.:..|...|||.:.||
  Fly   282 IRLLF--DNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNL 344

  Fly   451 HTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTV-PLA 514
            .||.||:|.|::|:.....|           |.|           ..::.||||||::|.: |||
  Fly   345 DTLDLSYNNLEFLEEQIFGG-----------NTL-----------PRMRRLNLNGNRMKHLHPLA 387

  Fly   515 LRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRI 579
            ..::..|..:.||.|.:..::...|..:..|..|.|..|.||.|         ||.:|
  Fly   388 FSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEI---------NLDVL------- 436

  Fly   580 AVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDN 624
                    |..||:|.:.:|.|.|..:..:..:.|:|..:.|..|
  Fly   437 --------ESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGN 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		LRR_8	171..236	CDD:290566	18/64 (28%)
		leucine-rich repeat	172..201	CDD:275380	5/28 (18%)
		leucine-rich repeat	202..278	CDD:275380	14/75 (19%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	65/198 (33%)
		leucine-rich repeat	279..302	CDD:275380	8/23 (35%)
		LRR_8	301..386	CDD:290566	27/88 (31%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR	350..729	CDD:227223	81/280 (29%)
		leucine-rich repeat	352..375	CDD:275380	5/26 (19%)
		leucine-rich repeat	376..401	CDD:275380	11/24 (46%)
		LRR_RI	<401..626	CDD:238064	65/225 (29%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	2/22 (9%)
		leucine-rich repeat	498..518	CDD:275380	10/20 (50%)
		leucine-rich repeat	521..544	CDD:275380	5/22 (23%)
		leucine-rich repeat	545..566	CDD:275380	7/20 (35%)
		leucine-rich repeat	569..592	CDD:275380	3/22 (14%)
		leucine-rich repeat	593..615	CDD:275380	4/21 (19%)
		leucine-rich repeat	616..637	CDD:275380	3/9 (33%)
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	48/202 (24%)
		LRR_8	104..164	CDD:290566	19/68 (28%)
		leucine-rich repeat	106..129	CDD:275380	7/31 (23%)
		leucine-rich repeat	130..153	CDD:275380	8/22 (36%)
		leucine-rich repeat	154..195	CDD:275380	15/80 (19%)
		LRR_RI	194..455	CDD:238064	92/309 (30%)
		LRR_8	194..254	CDD:290566	17/60 (28%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	24/60 (40%)
		leucine-rich repeat	272..295	CDD:275380	11/24 (46%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	26/82 (32%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	11/46 (24%)
		LRR_8	368..428	CDD:290566	19/59 (32%)
		leucine-rich repeat	370..393	CDD:275380	10/22 (45%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840